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Furin Antibody (YA1441)

MCE 站：Furin Antibody (YA1441)

Furin Antibody (YA1441) 是无偶联基团的、靶向 Furin 的 IgG 抗体 (克隆号：YA1441)，预测分子量为 87 kDa (实际观测：87 kDa)。Furin Antibody (YA1441) 可用于人、 小鼠、 大鼠背景下的 WB、IHC-P、ICC/IF 实验。

Synonyms: FUR; FURIN; PACE; PCSK3; SPC1

研究背景：The related gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein ａnd peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, ａnd brain. The encoded protein undergoes an initial autocatalytic processing event in the ER ａnd then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place ａnd the catalytic activity is acquired. Like other members of The convertase family, the product of The related gene specifically cleaves substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor ａnd von Willebrand factor. It is thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 ａnd gp140, ａnd may play a role in tumor progression. Unlike SARS-CoV ａnd other coronaviruses, the spike protein of SARS-CoV-2 is thought to be uniquely cleaved by The protease. Alternative splicing results in multiple transcript variants.

基因 ID：5045

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