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Butyric acid

CAS No. : 107-92-6

MCE 站：Butyric acid

产品活性：Butyric acid 是一种 HDAC 抑制剂，具有抗肿瘤活性。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics  |  Metabolic Enzyme/Protease

作用靶点：HDAC  |  Endogenous Metabolite

In Vitro: Butyric acid is a HDAC inhibitor. Butyric acid induces morphological changes, inhibits cell proliferation ａnd impairs cell viability in NPC cells. Sodium Butyrate (1, 5, 10 mM) is cytotoxic to NPC cells, inducing a dose- ａnd time-dependent decrease in cell viability, in both 5-8F ａnd 6-10B cells. Sodium Butyrate induces nasopharyngeal carcinoma cell apoptosis by activating the mitochondrial apoptotic axis. Moreover, SOCE inhibition ａnd disruption of the CRAC channel can attenuate the apoptosis induced by Sodium Butyrate. Sodium butyrate significantly decreases cell viability, accompanied by reduced levels of p-mTOR ａnd PCNA protein. Sodium butyrate dose-dependently induces cell cycle arrest in G0/G1 phase ａnd reduces the numbers of cells in S phase. In addition, relative expression of p21, p27, ａnd pro-apoptosis bak genes, ａnd protein levels of p21Waf1/Cip1, p27Kip1, cyclinD3, CDK4, ａnd Cleave-caspase3 are increased by higher concentrations of sodium butyrate (1, 5, 10 mM), ａnd the levels of cyclin D1 ａnd CDK6 are reduced by 5 ａnd 10 mM butyrate.

In Vivo: Sodium Butyrate (300 mg/kg, s.c.) provides almost complete neuroprotection in comparison with non-treated animals. Sodium butyrate results in an increased number of microglial cells to 150% of vehicle-treated animals in the ipsilateral side. Sodium butyrate promotes the polarization of microglia from M1- to M2-like phenotype after neonatal hypoxia-ischemia. Sodium butyrate (300 mg/kg, s.c.) in combination with AK-7 (20 mg/kg, i.p.) significantly alleviates this reduction of the time spent exploring new objects, ameliorates the reduction of the number of Ki67-positive cells ａnd DCX-immunoreactive neuroblasts in the dentate gyrus of the mice. In addition, sodium butyrate reverses SIRT2-related age phenotypes.

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