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Cefiderocol

CAS No. : 1225208-94-5

MCE 站：Cefiderocol

产品活性：Cefiderocol (S-649266) 是一种铁载体头孢菌素，对有氧革兰氏阴性细菌 (Gram-negative bacterial) 种类具有强效广谱的活性。

研究领域：Anti-infection

作用靶点：Bacterial  |  Antibiotic

In Vitro: Cefiderocol (S-649266), a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species, including carbapenem-resistant strains of Enterobacteriaceae ａnd nonfermenting bacteria such as Pseudomonas aeruginosa ａnd Acinetobacter baumannii. Cefiderocol has affinity mainly for PBP3 of Enterobacteriaceae ａnd nonfermenting bacteria similar to that of GR20263. A deficiency of the iron transporter PiuA in P. aeruginosa or both CirA ａnd Fiu in Escherichia coli can cause 16-fold increases in cefiderocol MICs, suggesting that these iron transporters contribute to the permeation of cefiderocol across the outer membrane. The deficiency of OmpK35/36 in Klebsiella pneumoniae ａnd the overproduction of efflux pump MexA-MexB-OprM in P. aeruginosa show no significant impact on the activity of cefiderocol.

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