MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

AKBA

CAS No. : 67416-61-9

MCE 站：AKBA

产品活性：AKBA (Acetyl-11-keto-β-boswellic acid) 是一种从乳香中提取出的活性化合物，是新颖的 Nrf2 的活化剂。

研究领域：Metabolic Enzyme/Protease  |  NF-κB  |  Immunology/Inflammation

作用靶点：HIF/HIF Prolyl-Hydroxylase  |  Reactive Oxygen Species  |  Endogenous Metabolite

In Vitro: AKBA (Acetyl-11-keto-β-boswellic acid) significantly reduced infarct volumes ａnd apoptotic cells, ａnd also increased neurologic scores by elevating the Nrf2 ａnd HO-1 expression in brain tissues in middle cerebral artery occlusion (MCAO) rats at 48 hours post reperfusion. In primary cultured neurons, AKBA increased the Nrf2 ａnd HO-1 expression, which provided protection against OGD-induced oxidative insult. Additionally, AKBA treatment increased Nrf2 binding activity to antioxidant-response elements (ARE).
AKBA (Acetyl-11-keto-β-boswellic acid) significantly inhibited human colon adenocarcinoma growth, showing arrest of the cell cycle in G1-phase ａnd induction of apoptosis.
AKBA (Acetyl-11-keto-β-boswellic acid) triggered significant lipolysis in 3T3-L1 adipocytes as shown by reduced neutral lipids in cytosol ａnd increased free fatty acids in culture medium. Increased lipolysis by AKBA was accompanied by up-regulation of lipolytic enzymes, adipocyte triglyceride lipase (ATGL) ａnd hormone sensitive lipase (HSL), ａnd a decreased expression of lipid droplet stability regulator perilipin. In addition, AKBA (Acetyl-11-keto-β-boswellic acid) treatment reduced phenotypic markers of mature adipocyte aP2, adiponectin ａnd glut-4 in mature adipocytes.

In Vivo: AKBA (Acetyl-11-keto-β-boswellic acid) significantly prevented the formation of intestinal adenomatous polyps without toxicity to mice. AKBA＇s activity both in the prevention of small intestinal ａnd colonic polyps was more potently than aspirin. Histopathologic examination revealed that AKBA＇s effect, that is the reduction of polyp size ａnd degree of dysplasia, was more prominent in larger sized polyps, especially those originating in colon.
AKBA (Acetyl-11-keto-β-boswellic acid) administration in mice effectively delayed the growth of HT-29 xenografts without signs of toxicity. The activity of AKBA was more potent than that of aspirin.
AKBA (Acetyl-11-keto-β-boswellic acid) exhibited anti-cancer activity in vitro ａnd in vivo. With oral application in mice, AKBA significantly inhibited SGC-7901 ａnd MKN-45 xenografts without toxicity.

相关产品：Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Natural Product Library  |  Anti-Cancer Compound Library  |  Human Endogenous Metabolite Compound Library  |  Anti-Aging Compound Library  |  Antioxidants Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Ferroptosis Compound Library  |  Terpenoids Library  |  Pyroptosis Compound Library  |  Glutamine Metabolism Compound Library  |  Traditional Chinese Medicine Monomer Library  |  FDA Approved & Pharmacopeial Drug Library  |  Anti-Breast Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Angiogenesis Related Compound Library  |  Mitochondria-Targeted Compound Library  |  Transcription Factor Targeted Library  |  Food-Sourced Compound Library   |  Rapamycin  |  3-Methyladenine  |  Acetylcysteine  |  5-Fluorouracil  |  H2DCFDA  |  ATP  |  Retinoic acid  |  Hydrocortisone  |  Docetaxel  |  Quercetin  |  Estradiol  |  Mitoqui mesylate  |  Melatonin  |  Nicotinamide  |  Cytarabine  |  Roxadustat  |  Isoprenaline hydrochloride  |  Prostaglandin E2  |  Acetaminophen  |  DMOG  |  (-)-Epigallocatechin Gallate  |  L-Ascorbic acid  |  PT-2385  |  β-Nicotinamide mononucleotide  |  Mito-TEMPO  |  Calcitriol  |  Diphenyleneiodonium chloride  |  DHEA  |  Liothyronine  |  Luteolin

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供*新*全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药收录了MCE客户的科研成果；
•   专业团队跟踪*新的制药及生命科学研究进展，为您提供全球*新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。