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Ginsenoside C-K

CAS No. : 39262-14-1

MCE 站：Ginsenoside C-K

产品活性：Ginsenoside C-K 是一种 Ginsenoside Rb1 的细菌代谢物。Ginsenoside C-K 通过抑制诱生型一氧化氮合酶 (iNOS) 和 COX-2 来发挥抗炎作用。在人肝微粒体中，Ginsenoside C-K 抑制 CYP2C9 和 CYP2A6 活性，IC₅₀ 分别为 32.0±3.6 μM和 63.6±4.2 μM。

研究领域：Immunology/Inflammation  |  Metabolic Enzyme/Protease

作用靶点：COX  |  NO Synthase  |  Cytochrome P450

In Vitro: Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects mainly by reducing inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, ａnd proinflammatory cytokines. Ginsenoside C-K suppresses the expression of proinflammatory cytokines by downregulating the activities of IRAK-1, MAPKs, IKK-α, ａnd NF-κB in LPS-treated murine peritoneal macrophages. Ginsenoside C-K also suppresses the expression of iNOS ａnd COX-2 by inhibiting NF-κB signaling in LPS-stimulated RAW264.7 cells. In zymosan-treated bone-marrow-derived macrophages (BMDMs) ａnd RAW264.7 cells, Ginsenoside C-K inhibits inflammatory responses by negatively regulating the secretion of proinflammatory cytokines, the activation of MAPKs, ａnd the generation of ROS. In addition, anti-inflammatory activity of Ginsenoside C-K has been observed in LPS-stimulated microglial cells. Ginsenoside C-K hinders inflammatory responses by controlling both the generation of ROS ａnd the activities of MAPKs, NF-κB, ａnd AP-1. Ginsenoside C-K, a major metabolite of ginsenosides in the gastrointestinal tract, inhibits NF-κB signaling in a PXR-dependent manner. Ginsenoside C-K is shown to promote recovery of dextran sulfate sodium (DSS) -induced colitis by suppressing NF-κB activation. Ginsenoside C-K significantly reduces TNF-α-induced upregulation of IL-1β ａnd iNOS mRNA levels, ａnd restores the mRNA levels of PXR ａnd CYP3A4 in LS174T cells. Ginsenoside C-K, one of the intestinal metabolites of 20(S)-protopanaxadiol derivatives, exhibits an inhibition against the activity of CYP2C9 in human liver microsomes with an IC₅₀ value of 32.0±3.6 μM, a weak inhibition against the activity of CYP2A6 in human liver microsomes with an IC₅₀ value of 63.6±4.2 μM, ａnd an even weaker inhibition against the activity of CYP2D6 in human liver microsomes with an IC₅₀ value of more than 100 μM.

In Vivo: The weight of the collagen-induced arthritis (CIA) mice increases slowly ａnd is significantly less than that of the normal DBA/1 mice beginning on d 3 after injection of the emulsion. Ginsenoside C-K (28, 56, ａnd 112 mg/kg) mice recover their weight by d 32 after the emulsion injection. Ginsenoside C-K (56 ａnd 112 mg/kg) ａnd Methotrexate (MTX)-treated (2 mg/kg) mice show significantly increased body weight on d 50 as compared with CIA mice. Hind paw-swelling began on d 24 post-immunization. CIA mice are treated from d 28 to d 50. Arthritis scores are measured every 4 d beginning on d 24. Ginsenoside C-K (56 ａnd 112 mg/kg) significantly reduces the arthritis scores of the mice on d 51.

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