联系方式：
CE3F4产品描述：CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac1), with IC₅₀s of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively.IC50 & Target: IC50: 10.7 μM (Epac1), 66 μM (Epac2(B))^[1]In Vitro: CE3F4 is a selective antagonist of Epac1, with IC₅₀s of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively. CE3F4 is more active on Epac1 than (S)-stereoisomer ((S)-CE3F4, IC₅₀, 56 μM), but less active than (R)-CE3F4 (IC₅₀, 5.8 μM). CE3F4 (50 μM) shows more inhibitory activities against GEF activity of Epac1, than that of Epac2(AB) or Epac2(B)^[1]. CE3F4 reduces the exchange activity of Epac1 induced by 007, with IC₅₀ of 23 ± 3 μM. CE3F4 (40 μM) specifically inhibits Epac1 guanine nucleotide exchange activity without interference with Rap1 activity or Epac1-Rap1 interaction. CE3F4 has no influence on PKA activity. CE3F4 (20 μM) inhibits Epac-induced Rap1 activation in living cultured HEK293 cells^[2]. CE3F4 (20 μM) significantly inhibits the late phase of ERK activation stimulated by glucose in INS-1 cells^[3].
产品链接：www.medchemexpress.com/CE3F4.html

研究领域：Others

靶点：Others

相关产品：SBE-β-CD  |  MPTP hydrochloride  |  Cyclosporin A  |  Etomoxir  |  Ceruletide  |  Acetylcysteine  |  GC376  |  GKT137831  |  GSK2795039  |  JC-1  |  RSL3 1S,3R-  |  BPTES  |  Ademetionine  |  D-Luciferin  |  H2DCFDA  |  



公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商， 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。
MCE 对每批产品都进行严格的LCMS和NMR检验，其产品已被全球近万名客户广泛使用并发表大量文章、；
MCE 定期增加各领域热门抑制剂、激动剂，不断扩增已有化合物库，以满足*新的科研需求；
数千种产品在上海有充足备货，24-48小时内送达客户；
大量产品提供免费试用装；已为全球多个知名企业、院校构建各种定制型化合物库。

联系方式：