联系方式：
Tetrandrine产品描述：Tetrandrine is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca²⁺ current (ICa) and Ca²⁺-activated K⁺ current.IC50 & Target: Ca²⁺ current^[1]
K⁺ current^[1]In Vitro: The effects of Tetrandrine, a bis-benzyl-isoquinoline alkaloid, on voltage-gated Ca²⁺ currents (ICa) and on Ca²⁺-activated K⁺ current (IK(Ca)) and channels in isolated nerve terminals of the rat neurohypophysis are investigated using patch-clamp techniques. The non-inactivating component of ICa is inhibited by external Tetrandrine in a voltage- and dose-dependent manner, with an IC₅₀=10.1μM. Tetrandrine decreases the channel-open probability, within bursts, with an IC₅₀=0.21 μM^[1]. To evaluate the effects of Tetrandrine on HCC cells, Huh7, HCCLM9 and Hep3B cells are treated with 0 (DMSO), 0.5, 1, 2 or 4 μM of Tetrandrine for 24 h. The cell proliferation assay indicates that Tetrandrine exhibits almost no effect on the inhibition of HCC cell proliferation at 0.5-2 μM. However, Tetrandrine inhibits HCC cell migration in a dose-dependent manner. Furthermore, a wound-healing and transwell assay shows that 2 μM Tetrandrine significantly inhibits HCC cell migration and invasion^[2].In Vivo: To evaluate the effect of Tetrandrine on the inhibition of tumor metastasis in vivo, HCCLM9 subcutaneous tumor xenograft models is established with athymic nude mice. When the tumor volume reach approximately 50 mm³, nude mice are orally administered vehicle or Tetrandrine (30 mg/kg) every other day for 37 days. Tetrandrine treatment inhibits tumor growth by reducing the tumor volume and weight^[2].
产品链接：www.medchemexpress.com/Tetrandrine.html

研究领域：Membrane Transporter/Ion Channel

靶点：Calcium ChannelPotassium Channel

相关产品：Nigericin sodium salt  |  Senicapoc  |  Neomycin sulfate  |  Nifedipine  |  E-4031  |  Ginsenoside Rg3  |  Mibefradil dihydrochloride  |  20-HETE  |  Acetylcholine chloride  |  Nimodipine  |  4-Aminopyridine  |  TRAM-34  |  Dantrolene sodium hemiheptahydrate  |  Bay-K-8644 ((R)-(+)-)  |  Cilnidipine  |  



公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商， 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。
MCE 对每批产品都进行严格的LCMS和NMR检验，其产品已被全球近万名客户广泛使用并发表大量文章、；
MCE 定期增加各领域热门抑制剂、激动剂，不断扩增已有化合物库，以满足*新的科研需求；
数千种产品在上海有充足备货，24-48小时内送达客户；
大量产品提供免费试用装；已为全球多个知名企业、院校构建各种定制型化合物库。

联系方式：