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Antitumor Compound 2，一种丁烯基苯基磷酸酯衍生物，可用于治疗乳腺癌和无排卵性不育

Anacardic Acid产品描述：Anacardic Acid, extracted from cashew nut shell liquid, is a histone acetyltransferase inhibitor, inhibits HAT activity of p300 ａnd PCAF, with IC₅₀s of ?8.5 μM ａnd ?5 μM, respectively.IC50 & Target: IC50: ?8.5 μM (p300 HAT), ?5 μM (PCAF)^[1]In Vitro: Anacardic Acid is a histone acetyltransferase, inhibits HAT activity of p300 ａnd PCAF, with IC₅₀s of ?8.5 μM ａnd ?5 μM, respectively^[1]. Anacardic Acid (300 μM) inhibits mycelial growth. Anacardic Acid (50 μM) induces apoptosis-like characteristics in M. oryzae, ａnd the effect is caspase independent. Anacardic Acid (1-80 μM) leads to loss of mitochondrial potential. Anacardic Acid (1-60 μM) also exhibits antioxidant activity in M. oryzae^[3].In Vivo: Anacardic acid (5 mg/kg, i.p.) attenuates the binding of HATs to the promoter of MEF2A ａnd reverse hyperacetylation of H3K9ac caused by phenylephrine in C57BL/6 mice. Anacardic acid inhibits the level of transcription on MEF2A ａnd cardiac development-related downstream genes, attenuates the protein overexpression of cardiac downstream genes caused by phenylephrine, reverses ａnd attenuates cardiac hypertrophy in the hearts of mice exposed to phenylephrine, ａnd attenuates the left ventricular pressure ａnd improves cardiac function in the cardiac hypertrophy mice^[2].
产品链接：www.medchemexpress.com/Anacardic_Acid.html

研究领域：Epigenetics

靶点：Histone AcetyltransferaseEpigenetic Reader Domain

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