WBP全身体积描记系统
http://www.app17.com/c133793/products/d7440710.html

产品描述：
全身体积描记系统（whole-body plethysmograph，WBP）作为无创检测动物肺功能的一种经典方式，避免了麻醉及气管插管测试对动物造成的损伤，可以对2019-nCov、SARS、MERS感染下的动物肺功能指标进行长期跟踪研究。测量指标如潮气量、分钟通气量、呼气峰值流速、吸气峰值流速、呼吸频率、Penh等。这些数据可以和临床数据建立直接的相关性，适用于新型冠状病毒、SARS‐CoV和MERS等感染研究。

产品详情：
气道高反应性（Airway hyperresponsiveness，AHR）、气道炎症和可逆的气道阻塞是支气管哮喘的特征。通过动物模型可研究用于防治气道炎症和AHR的方法和受试药物。传统的方式多采用气管插管，检测气道阻力和肺顺应性来评估动物气道功能的改变。但这些方法有其局限性，如整体试验中麻醉药物的影响，麻醉深浅和麻醉药物对AHR的神经源和气道炎症的影响，实验人员手术操作技术上的要求和耗时，麻醉或手术后动物存活困难不能长期跟踪研究等因素。
无约束全身体积描记法（whole-body plethysmograph，WBP）可以对清醒自由活动的小动物进行肺功能及气道反应相关的测试，避免了创伤性气管切开术及麻醉的影响，在动物处于自然状态下就可以直接测定其气道反应性。而且每次可以同时检测多只动物。整个实验过程简便快捷，并适合长期跟踪研究。

实验研究：

MERS病毒感染后，经 RDV 和LPV/RTV-IFNb治疗后肺功能的改善测试如下：
治疗研究，经RDV和LPV/RTV-IFNb治疗后，肺功能改善。
相比对照组，经RDV治疗和LPV + RTVIFNb 低剂量治疗，5天后，动物的EF50减小、PenH减小、Rpef回到基准水平。


数据显示：
流感病毒感染2-15天后的小鼠呼吸功能检测，PR/8比x31感染的小鼠具有更严重的呼吸功能损伤
A：无感染的小鼠和感染9天后的小鼠呼吸信号波形图。
B：呼吸频率（次/min）；C：潮气量（ml）；D：分钟通气量（ml）；E：呼气时间（s）

产品特点：
适用动物种类:小鼠、幼鼠、大鼠、豚鼠、兔子、犬、猫、小型猪、猴等动物
具有喂食进水装置以方便超长时间的实验
测量通道：1-64通道
自动化偏流控制功能
可配置高频振荡雾化给药系统
特殊的减噪结构设计，可有效减少环境变化造成的干扰
可进行偏流仪降噪，提高信号的信噪比，减少系统噪音
支持外接氮气或其它气体，完成低氧实验
具有分析软件，数据可保存至excel或txt格式

可选择的功能：
温湿度检测功能
自动校准功能，同对描记器进行全自动标定，减少手工操作引入的误差，提高实验效率
咳嗽检测功能
自动活动状态静脉注射给药
心电、体温、活动度遥测
同步视频采集和记录
其它功能可定制

检测参数：

Ti：吸气时间（s）
Te：呼气时间（s）
PIF：大吸气流速（ml/s）
PEF：大呼气流速（ml/s）
Volbal:呼吸比
F：呼吸频率（次/min）
Vt：潮气量（ml）
Mv：分钟通气量（ml）
AV：累积体积（ml）
EF50：呼出50%气量时对应的呼气流速（ml/s）
EIP:吸气峰值压力（仅在侵入式法测量时有效）
EEP：呼气峰值压力（仅在侵入式法测量时有效）
TR:松弛时间
PenH：增强呼气间歇（enhanced pause）

选型说明：

 
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原创作者：上海塔望智能科技有限公司