哮喘Asthma 

肺纤维化Lung Fibrosis

慢性阻塞性肺病COPD

急性呼吸系统疾病Acute Respiratory Disorders

模型开发Model Development 

安全评估 Safety Assessment

毒理学Toxicology

型号选择

参考文献

• [1]Sun Lingna,Fan Mingrui,Huang Dong,Li Bingqin,Xu Ruoting,Gao Feng,Chen Yanzuo. Clodronate-loaded liposomal ａnd fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis[J]. Biomaterials,2021(prepublish):

• [2]李宁,李红鹏,张本炎,张柳,沈继敏,李庆云.高脂膳食对小鼠呼吸功能和膈肌纤维的影响及其线粒体机制[J].中华医学杂志,2021,101(36):2893-2899.

• [3]Xiong Jiaying,Zhuang Tao,Ma Yurong,Xu Junyi,Ye Jiaqi,Ma Ru,Zhang Shuang,Liu Xin,Liu Bi-Feng,Hao Chao,Zhang Guisen,Chen Yin. Optimization of bifunctional piperidinamide derivatives as σ1R Antagonists/MOR agonists for treating neuropathic pain[J]. European Journal of Medicinal Chemistry,2021,226:

•  

  [4]Yumei Zhou, Haihong Zhao, Tieshan Wang, Xiaoshan Zhao, Ji Wang ａnd Qi Wang，Anti-Inflammatory ａnd Anti-asthmatic Effects of TMDCT Decoction in Eosinophilic Asthma Through Treg/ Th17 Balance. Frontiers, 2022.819728:

•  

  [5]Yumei Zhou,  Tieshan Wang, Xiaoshan Zhao, Ji Wang ａnd Qi Wang，Plasma Metabolites ａnd Gut Microbiota Are Associated With T cell Imbalance in BALB/c Model of Eosinophilic Asthma. Frontiers, 2022. 819747:

•  

  [6]Rui Zheng, Wenhao Yang, Yuting Wen, Liang Xie, Fang Shi, Danli Lu, Jiaxin Luo, Yan Li, Ting Chen, Lina Chen, Wenming Xu and Hanmin Liu.Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening.CDDpress.2022(13:559)：

•  

  [7]Wenyang Wang, Min Mu, Yuanjie Zou, Bing Li,Hangbing Cao, Dong Hu and Xinrong Tao.Inflammation and fibrosis in the coal dust-exposed lung described by confocal Raman spectroscopy.PeerJ,DOl 10.7717/2022：

   

  [8]Dongyi Zhu,Qian Zhang,Qinchuan Li,Guangxue Wang,Zhongliang Guo.Inhibition of AHNAK nucleoprotein 2 alleviates pulmonary fibrosis by downregulating the TGF-β1/Smad3 signaling pathway.The Journal Gene Medicine.First published: 26 July 2022:

•  

  [9]Jiawen Zhou,Haiyun Chen,Qiuyi Wang,Sihan Chen,Rong Wang,Ziyang Wang,Cuicui Yang,Ao Chen,Jingyu Zhao,Zihao Zhou,Zhiyuan Mao,Guoping Zuo,Dengshun Miao,Jianliang Jin.Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription.Aging Cell WILEY.First published: 30 July 2022：

•  

  [10]Yapeng,LuPanpanChang,WangwangDing,JiangpeiBian,DanWang,XuetingWang,QianqianLuo,XiaomeiWu,LiZhu.Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells.Institute of Special Environmental Medicine, Nantong University, Nantong, 226019, China.Received 7 March 2022, Revised 27 June 2022, Accepted 30 June 2022, Available online 3 July 2022, Version of Record 12 July 2022.

   

• [11]Mengjun Zhanga,Huiyang Jiang,Lan Wu,Haoyu Lu,Hriday Bera,Xing Zhao,Xiong Guo,Xulu Liu,Dongmei Cun,Mingshi Yang.Airway epithelial cell-specific delivery of lipid nanoparticles loading siRNA for asthma treatment.Journal of Controlled Release Volume 352, December 2022.

• [12]Xue Lu,Zhu-Xia Tan,Wen-Jing Wang,Ping Zhan,Yan Wang,Lin Fu,Lan Gao,Hui. Zhao,Hua Wang,De-Xiang Xu.Juvenile arsenic exposure aggravates goblet cell hyperplasia ａnd airway mucus secretion in ovalbumin-sensitized mice.Environmental Pollution Volume 315, 15 December 2022, 120462

• [13]Gu, W., Lei, J., Zhu, H. et al. Effect of the BMPR-II-SMAD3/MRTF pathway on proliferation ａnd migration of ASMCs ａnd the mechanism in asthma. Mol Biol Rep 49, 9283–9296 (2022). https://doi.org/10.1007/s11033-022-07764-9
  

  [14]Hu M, Yang J, Xu Y, Liu J. MDH1 ａnd MDH2 Promote Cell Viability of Primary AT2 Cells by Increasing Glucose Uptake. Computational ａnd Mathematical Methods in Medicine  [J]. Hindawi Computational ａnd Mathematical Methods in Medicine/Volume 2022, Article ID 2023500, 15 pages

  [15]Zhou J, Chen H, Wang Q, Chen S, Wang, R, Wang Z, Yang C, Chen A, Zhao J, Zhou Z, Mao Z, Zuo G, Miao D, & Jin J. "Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription" [J]. Aging Cell, 21, e13680.

  [16]WenJing Wang , Xue Lu , Zhao Li , Kun Peng , Ping Zhan , Lin Fu , Yan Wang , Hui Zhao , Hua Wang , De-Xiang Xu , Zhu-Xia Tan.”Early-life cadmium exposure elevates susceptibility to allergic asthma in ovalbumin-sensitized ａnd challenged mice”[J] Ecotoxicology ａnd Environmental Safety 255 (2023) 114799 

  [17]Zhou Y, Hu L, Zhang H, Zhang H, Liu J, Zhao X, Wang J, Wang Q."Guominkang formula alleviate inflammation in eosinophilic asthma by regulating immune balance of Th1/2 ａnd Treg/Th17 cells."[J].Frontiers in Pharmacology, 14 Oct 2022, 13:978421
  [18]Bao XC, Wang N, Xu J, Ma J ａnd Fang Y-Q (2023) “Effects of different simulated submarine escape depths by free ascent in animal models. “[J]Front. Physiol. 14:1107782.

  ​

  
  

*我公司可以根据客户的特殊应用、特殊需求提供功能定制服务，也可以提供相关的实验服务，详情请来电咨询。