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上海塔望智能科技有限公司 主营产品: 病造模设备、动物呼吸检测、(高/低压、高/低氧)控制器、麻醉机、能量代谢、脊髓/脑损伤仪、宠医医疗器械、动物实验服务

当前位置: 易推广 > 生命科学 > 生物工程设备 > 其他 > 上海塔望智能科技有限公司 > 产品展示 > 呼吸检测系统 > WBP全身体积描记系统

WBP全身体积描记系统

价格:¥电议

品牌名称:$brandModel.Title(进口品牌)型号:WBP系列 原产地:中国大陆 发布时间:2018/4/2 15:17:55更新时间:2024/12/10 15:34:14

产品摘要:WBP全身体积描记法(whole-body plethysmograph,WBP)可以对清醒自由活动的小动物进行肺功能及气道反应相关的测试,避免了创伤性气管切开术及麻醉的影响,在动物处于自然状态下就可以直接测定其气道反应性。而且每次可以同时检测多只动物。整个实验过程简便快捷,并适合长期跟踪研究。

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手机网站:http://m.yituig.com/c133793/

商铺地址:http://tow-int.com

详细内容

产品描述:
全身体积描记系统(whole-body plethysmograph,WBP)作为无创检测动物肺功能的一种经典方式,避免了麻醉及气管插管测试对动物造成的损伤,可以对2019-nCov、SARS、MERS感染下的动物肺功能指标进行长期跟踪研究。测量指标如潮气量、分钟通气量、呼气峰值流速、吸气峰值流速、呼吸频率、Penh等。这些数据可以和临床数据建立直接的相关性,适用于新型冠状病毒、SARS‐CoV和MERS等感染研究。

产品详情:
气道高反应性(Airway hyperresponsiveness,AHR)、气道炎症和可逆的气道阻塞是支气管哮喘的特征。通过动物模型可研究用于防治气道炎症和AHR的方法和受试药物。传统的方式多采用气管插管,检测气道阻力和肺顺应性来评估动物气道功能的改变。但这些方法有其局限性,如整体试验中麻醉药物的影响,麻醉深浅和麻醉药物对AHR的神经源和气道炎症的影响,实验人员手术操作技术上的要求和耗时,麻醉或手术后动物存活困难不能长期跟踪研究等因素。
无约束全身体积描记法(whole-body plethysmograph,WBP)可以对清醒自由活动的小动物进行肺功能及气道反应相关的测试,避免了创伤性气管切开术及麻醉的影响,在动物处于自然状态下就可以直接测定其气道反应性。而且每次可以同时检测多只动物。整个实验过程简便快捷,并适合长期跟踪研究。

实验研究:

MERS病毒感染后,经 RDV 和LPV/RTV-IFNb治疗后肺功能的改善测试如下:
治疗研究,经RDV和LPV/RTV-IFNb治疗后,肺功能改善。
相比对照组,经RDV治疗和LPV + RTVIFNb 低剂量治疗,5天后,动物的EF50减小、PenH减小、Rpef回到基准水平。


数据显示:
流感病毒感染2-15天后的小鼠呼吸功能检测,PR/8比x31感染的小鼠具有更严重的呼吸功能损伤
A:无感染的小鼠和感染9天后的小鼠呼吸信号波形图。
B:呼吸频率
(次/min);C:潮气量(ml);D:分钟通气量(ml);E:呼气时间(s

产品特点:
适用动物种类:小鼠、幼鼠、大鼠、豚鼠、兔子、犬、猫、小型猪、猴等动物
具有喂食进水装置以方便超长时间的实验
测量通道:1-64通道
自动化偏流控制功能
可配置高频振荡雾化给药系统
特殊的减噪结构设计,可有效减少环境变化造成的干扰
可进行偏流仪降噪,提高信号的信噪比,减少系统噪音
支持外接氮气或其它气体,完成低氧实验
具有分析软件,数据可保存至excel或txt格式

可选择的功能:

温湿度检测功能
自动校准功能,同对描记器进行全自动标定,减少手工操作引入的误差,提高实验效率
咳嗽检测功能
自动活动状态静脉注射给药
心电、体温、活动度遥测
同步视频采集和记录
其它功能可定制

检测参数:

Ti:吸气时间(s)
Te:呼气时间(s)
PIF:大吸气流速(ml/s)
PEF:大呼气流速(ml/s)
Volbal:呼吸比
F:呼吸频率(次/min)
Vt:潮气量(ml)
Mv:分钟通气量(ml)
AV:累积体积(ml)
EF50:呼出50%气量时对应的呼气流速(ml/s)
EIP:吸气峰值压力(仅在侵入式法测量时有效)
EEP:呼气峰值压力(仅在侵入式法测量时有效)
TR:松弛时间
PenH:增强呼气间歇(enhanced pause)

选型说明:

名称 型号 说明 单位
全身体积描记系统 WBP-4M 四通道,小鼠
全身体积描记系统 WBP-4R 四通道,大鼠
全身体积描记系统 WBP-4MR 四通道,大小鼠通用
全身体积描记系统 WBP-8M 八通道,小鼠
全身体积描记系统 WBP-8R 八通道,大鼠
全身体积描记系统 WBP-8MR 八通道,大小鼠通用

 
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