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T6S2227SpinosinInhibitor,neuroprotective,Spinosin,inhibit,Aβ1-42
1. Spinosin ameliorated memory impairment induced through AβO, the serotonergic neurotransmitter system, and these effects were regulated, in part, through neuroprotective activity via the anti-inflammatory effects of Spinosin. 2. Spinosin exerts anxiolytic-like effects, and its mechanism of action appears to be modulated by GABAA and 5-HT1A receptors. 3. There was a wide brain regional tissue distribution of Spinosin. The concentrations of Spinosin in corpus striatum and hippocampus were higher
价 格：￥电议型 号：T6S2227产 地：中国大陆
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T83694Gastric Inhibitory Peptide (1-42) (porcine) TFA；化合物 Gastric Inhibitory Peptide (1-42) (porcine) TFAG
Gastric inhibitory peptide (GIP) (1-42), an endogenous incretin hormone comprising 42 amino acids, promotes insulin secretion. Expressed in the intestinal neuroendocrine K cells and submandibular gland, it enters circulation after meals. GIP (1-42) blocks histamine, pentagastrin, and insulin-induced gastric acid and pepsin secretion, enhances glucose-stimulated insulin release, and accelerates gastric emptying in rats.
价 格：￥电议型 号：T83694产 地：中国大陆
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T83508[Arg6]-β-Amyloid (1-42), england mutation；化合物 [Arg6]-β-Amyloid (1-42), england mutation[Arg6]-β-Amyl
[Arg6]-β-Amyloid (1-42), England mutation, is a biologically active peptide associated with autosomal dominant Alzheimer´s Disease in various kindreds. The English (H6R) mutation disrupts H6 interactions due to several mutations in the beta-amyloid precursor gene.
价 格：￥电议型 号：T83508产 地：中国大陆
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T83506[Asn23]-beta-Amyloid (1-42), iowa mutation；化合物 [Asn23]-beta-Amyloid (1-42), iowa mutation[Asn23]-bet
[Asn23]-beta-Amyloid (1-42), Iowa mutation, is a biologically active peptide exhibiting increased aggregation propensity and fibril toxicity. This mutation involves the substitution of Aspartic acid (Asp) at position 23 with Asparagine (Asn), contributing to autosomal dominant Alzheimer´s Disease in various kindreds due to its association with severe cerebral amyloid beta-protein angiopathy (CAA). Specifically, the mutation is a missense alteration at position 694 of the amyloid precursor
价 格：￥电议型 号：T83506产 地：中国大陆
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T80035Biotin-β-Amyloid (1-42), human TFA；化合物 Biotin-β-Amyloid (1-42), human TFABiotin-amyloid β-peptide (1
Biotin-β-Amyloid (1-42), human TFA, also known as Biotin-Amyloid β-Peptide (1-42) (human) TFA, is a biotin-labeled 42-amino acid peptide implicated in the pathogenesis of Alzheimer´s disease [1].
价 格：￥电议型 号：T80035产 地：中国大陆
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T76625(Lys22)-Amyloid β-Protein (1-42)；化合物 (Lys22)-Amyloid β-Protein (1-42)(Lys22)-Amyloid β-Protein (1-42
´(Lys22)-Amyloid β-Protein (1-42) represents a mutation of the wild-type (WT) Amyloid β-Protein (1-42) peptide [1].´
价 格：￥电议型 号：T76625产 地：中国大陆
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T76623(Gln22)-Amyloid β-Protein (1-42)；化合物 (Gln22)-Amyloid β-Protein (1-42)(Gln22)-Amyloid β-Protein (1-42
(Gln22)-Amyloid β-Protein (1-42), a Dutch mutation (E22Q) variant of β-Amyloid (1-42), demonstrates increased fibrillogenic and pathogenic characteristics [1].
价 格：￥电议型 号：T76623产 地：中国大陆
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T76588(Asp37)-Amyloid β-Protein (1-42)；化合物 (Asp37)-Amyloid β-Protein (1-42)(Asp37)-Amyloid β-Protein (1-42
´(Asp37)-Amyloid β-Protein (1-42) [1]´ refers to the G37D mutant variant of the wild-type Amyloid-beta (1-42) peptide.
价 格：￥电议型 号：T76588产 地：中国大陆
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T76465Biotinyl-Ahx-Amyloid β-Protein (1-42) (ammonium)；化合物 Biotinyl-Ahx-Amyloid β-Protein (1-42) (ammonium
Biotinyl-Ahx-Amyloid β-Protein (1-42) ammonium is an N-terminally biotin-tagged form of Amyloid β-Protein (1-42), which constitutes the main component of vascular and parenchymal amyloid deposits associated with Alzheimer´s disease [1].
价 格：￥电议型 号：T76465产 地：中国大陆
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T76464FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)；化合物 FITC-β-Ala-Amyloid β-Protein (1-42) (ammonium)FIT
FITC-β-Ala-Amyloid β-Protein (1-42) ammonium, a fluorescein isothiocyanate (FITC)-tagged monomer peptide of Aβ1-42, is instrumental in Alzheimer’s disease pathogenesis [1].
价 格：￥电议型 号：T76464产 地：中国大陆
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T76434Biotinyl-Amyloid β-Protein (1-42) (ammonium)；化合物 Biotinyl-Amyloid β-Protein (1-42) (ammonium)Biotiny
Biotinyl-Amyloid β-Protein (1-42) ammonium, a biotinylated variant of Amyloid β-Protein (1-42), is utilized in research focused on the conversion of Aβ1-42 to Aβ1-40 in the brain [1].
价 格：￥电议型 号：T76434产 地：中国大陆
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T76433Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42)；化合物 Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42)Cys-Gly-Lys-Arg
Cys-Gly-Lys-Arg-Amyloid β-Protein (1-42), a peptide fragment derived from amyloid β-protein (Aβ), plays a pivotal role in Alzheimer´s disease research [1].
价 格：￥电议型 号：T76433产 地：中国大陆
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T76432(D-Asp1)-Amyloid β-Protein (1-42)；化合物 (D-Asp1)-Amyloid β-Protein (1-42)(D-Asp1)-Amyloid β-Protein (1
(D-Asp1)-Amyloid β-Protein (1-42), a peptide fragment of amyloid β-protein (Aβ), serves as the primary constituent of vascular and parenchymal amyloid deposits associated with Alzheimer´s disease [1].
价 格：￥电议型 号：T76432产 地：中国大陆
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T76425(Glu20)-Amyloid β-Protein (1-42)；化合物 (Glu20)-Amyloid β-Protein (1-42)(Glu20)-Amyloid β-Protein (1-42
(Glu20)-Amyloid β-Protein (1-42) represents a variant of amyloid β-protein (Aβ) that fibrillizes more slowly. This is attributed to the Glu20 mutation, which diminishes Aβ42´s tendency to aggregate and inhibits the accumulation of this slowly fibrillizing peptide. Notably, amyloid β-protein serves as the principal constituent of amyloid deposits found in both the vascular system and brain parenchyma in Alzheimer´s disease [1] [2].
价 格：￥电议型 号：T76425产 地：中国大陆
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T76424(Gly22)-Amyloid β-Protein (1-42)；化合物 (Gly22)-Amyloid β-Protein (1-42)(Gly22)-Amyloid β-Protein (1-42
(Gly22)-Amyloid β-Protein (1-42), a peptide fragment of Amyloid β-Protein (Aβ), plays a crucial role in Alzheimer´s disease by forming the main component of both vascular and parenchymal amyloid deposits. The mutation from Glu22 to Gly22 in Aβ is known to enhance aggregation [1] [2].
价 格：￥电议型 号：T76424产 地：中国大陆
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T76397(Nle35)-Amyloid β-Protein (1-42) (ammonium)；化合物 (Nle35)-Amyloid β-Protein (1-42) (ammonium)(Nle35)-A
(Nle35)-Amyloid β-Protein (1-42) ammonium is a peptide.
价 格：￥电议型 号：T76397产 地：中国大陆
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T76396(Met(O2)35)-Amyloid β-Protein (1-42)；化合物 (Met(O2)35)-Amyloid β-Protein (1-42)(Met(O2)35)-Amyloid β-P
(Met(O2)35)-Amyloid β-Protein (1-42) is a peptide [1] .
价 格：￥电议型 号：T76396产 地：中国大陆
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T76395(Met(O)35)-Amyloid β-Protein (1-42)；化合物 (Met(O)35)-Amyloid β-Protein (1-42)(Met(O)35)-Amyloid β-Prot
(Met(O)35)-Amyloid β-Protein (1-42) represents the oxidized form of Methionine 35 in Aβ42, capable of producing an oligomer size distribution akin to that of Aβ40. This compound is utilized in Alzheimer’s disease (AD) research [1].
价 格：￥电议型 号：T76395产 地：中国大陆
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T61388hAChE/Aβ1-42-IN-1；化合物 hAChE/Aβ1-42-IN-1hAChE/Aβ1-42-IN-1
Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines and excellent brain-blood barrier (BBB) penetration with a broad safety margin. This compound shows promise for Alzheimer´s disease (AD) research [1].
价 格：￥电议型 号：T61388产 地：中国大陆
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T60940ChE/Aβ1-42-IN-1；化合物 ChE/Aβ1-42-IN-1ChE/Aβ1-42-IN-1
ChE/Aβ1-42-IN-1 (compound 28) is a potent aggregation inhibitor of ChE and Aβ 1-42 with excellent BBB permeability. The IC50 values of ChE/Aβ1-42-IN-1 for AChE, BuChE and Aβ 1-42 aggregation are 0.062, 0.767 and 1.227 μM, respectively. ChE/Aβ1-42-IN-1 is a potent multi-targeted anti-Alzheimer´s disease agent [1].
价 格：￥电议型 号：T60940产 地：中国大陆
