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TN71324,12-Dimethoxy-6-(7,8-dihydroxy-7,8-dihydrostyryl)-2-pyrone4,12Dimethoxy6(7,8dihydroxy7,8dihydrostyr
4,12-Dimethoxy-6-(7,8-dihydroxy-7,8-dihydrostyryl)-2-pyrone is a microbial metabolism of yangonin, a major styryl lactone from Piper methysticum.
价 格：￥电议型 号：TN7132产 地：中国大陆
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T11021DHODH-IN-12DHODHIN12,DHODH IN 12
DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.
价 格：￥电议型 号：T11021产 地：中国大陆
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T10965DBPR112DBPR-112,DBPR112
DBPR112 is an orally active furanopyrimidine-based EGFR inhibitor with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively. DBPR112 can occupy the ATP-binding site. DBPR112 has significant antitumor efficacy.
价 格：￥电议型 号：T10965产 地：中国大陆
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T9303MRTX1133KRAS,Ras,MRTX 1133,G12D,cells,active,wild-type,phosphorylation,mutant,MRTX1133,inactive,ERK,
MRTX1133 is a potent, selective, and noncovalent inhibitor of KRAS G12D. MRTX1133 exhibits an estimated KD against KRAS G12D of 0.2 pM. MRTX1133 inhibits mutant KRAS-dependent signal transduction by preventing SOS1-catalyzed nucleotide exchange and/or formation of the KRAS G12D/GTP/RAF1 complex. MRTX1133 selectively inhibits KRAS G12D mutant tumor cells with no effect on KRAS wild-type. MRTX1133 exhibits single digit nanomolar activity in cellular assays and marked in vivo efficacy in tumor mode
价 格：￥电议型 号：T9303产 地：中国大陆
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T6S1740Nardosinonecells,Nardosinone,Neurite,substances,PC12D,outgrowth-promoting,neuritogenic,inhibit,MAPK,
1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed to OGD, which may be relevant to the promotion of PKA and ERK signaling pathway. 3. Nardosinone enhances staurosporine- or dbcAMP-induced neurite outgrowth from PC12D cells, probably by amplifying both the MAP kinase-dependent and -independent signaling pathways of dbcAMP and stau
价 格：￥电议型 号：T6S1740产 地：中国大陆
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T62228KRAS G12D inhibitor 14
KRAS G12D inhibitor 14 is an effective inhibitor of KRAS G12D, showing significant antitumor effect and tumor growth inhibition in CT26 tumor models.
价 格：￥电议型 号：T62228产 地：中国大陆
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TN7214Galdosol6β,20Epoxy11,12dihydroxyabieta8,11,13triene7,20dione
Galdosol is a natural product found in Perovskia abrotanoides.
价 格：￥电议型 号：TN7214产 地：中国大陆
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T67868Oleana-2,12-dien-28-oic acidOleana2,12dien28oicacid
Oleana-2,12-dien-28-oic acid is an HBsAg and HBeAg inhibitor that obviously inhibit HBV deoxyribonucleic acid (HBV-DNA) replication in HepG2.2.15 cells. Oleana-2,12-dien-28-oic acid for the study of hepatitis B virus infection.
价 格：￥电议型 号：T67868产 地：中国大陆
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T81515Peptide 12d；化合物 Peptide 12dPeptide 12d
Peptide 12d, an antimicrobial peptide derived from wasp venom, induces antimicrobial effects through the stimulation of mast cell degranulation [1].
价 格：￥电议型 号：T81515产 地：中国大陆
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T79668PIK5-12d；化合物 PIK5-12dPIK5-12d
PIK5-12d, a potent PROTAC PIKfyve degrader (DC50: 1.48 nM), effectively induces cytoplasmic vacuolization and inhibits autophagic flux in various prostate cancer cell lines, concurrently halting their proliferation. This compound has demonstrated significant anti-tumor activity [1].
价 格：￥电议型 号：T79668产 地：中国大陆
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T79072KRAS G12D modulator-1；化合物 KRAS G12D modulator-1KRAS G12D modulator-1
KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and is utilized in cancer research [1].
价 格：￥电议型 号：T79072产 地：中国大陆
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T78212RMC-9805；化合物 RMC-9805KRAS G12D inhibitor 18|||KRAS G12D IN 18；KRAS G12D inhibitor 18|||KRAS G12D IN
RMC-9805 is a potent KRAS G12D inhibitor with potential anti-tumor and inhibitory activity against tumor cell proliferation for the study of pancreatic cancer.
价 格：￥电议型 号：T78212产 地：中国大陆
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T78170Kras4B G12D-IN-1；Kras4B G12D 抑制剂 1Kras4B G12D-IN-1
Kras4B G12D-IN-1 is an anticancer agent that functions as an inhibitor of the Kras4B G12D protein. It effectively reduces the expression of Kras protein in mouse embryonic fibroblasts (MEFs) harboring the Kras4B G12D mutation[1].
价 格：￥电议型 号：T78170产 地：中国大陆
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T77804KRAS G12D mutation regulator 4；化合物 KRAS G12D mutation regulator 4KRAS G12D mutation regulator 4
KRAS G12D mutation regulator 4 can be used in studies about Ras.
价 格：￥电议型 号：T77804产 地：中国大陆
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T75714Decapeptide-12；化合物 Decapeptide-12Decapeptide-12
Decapeptide-12, a competitive inhibitor of mushroom tyrosinase with an IC50 of 40 ?M and a Kd of 61.1 μM for the C-terminal residue of tyrosinase, is a small oligopeptide that reduces melanin content in melanocytes by interacting with tyrosinase and increasing transcription of SIRT. It is utilized in researching melanogenesis, senescence, and inflammation [1] [2] [3].
价 格：￥电议型 号：T75714产 地：中国大陆
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T74663KRAS G12D inhibitor 17；化合物 KRAS G12D inhibitor 17KRAS G12D inhibitor 17
KRAS G12D Inhibitor 17 (example 8), a quinazoline-linked (4R)-4-hydroxy-L-prolinamide compound, acts as a proteolysis targeting chimera (PROTAC) [1], specifically inducing degradation of the G12D-mutation KRAS protein.
价 格：￥电议型 号：T74663产 地：中国大陆
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T74607KRAS G12D inhibitor 15；化合物 KRAS G12D inhibitor 15KRAS G12D inhibitor 15
KRAS G12D inhibitor 15 is a potent inhibitor specifically targeting the KRAS G12D mutation. It holds potential for research into numerous diseases or disorders, including cancer and its metastases[1].
价 格：￥电议型 号：T74607产 地：中国大陆
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T73828KRAS G12D inhibitor 3 TFA；化合物 KRAS G12D inhibitor 3 TFAKRAS G12D inhibitor 3 TFA
KRAS G12D Inhibitor 3 TFA, exhibiting an inhibitory concentration (IC50) of less than 500 nM, is effective as an antitumor agent.
价 格：￥电议型 号：T73828产 地：中国大陆
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T72394KRAS G12D inhibitor 3；化合物 KRAS G12D inhibitor 3KRAS G12D inhibitor 3
KRAS G12D Inhibitor 3, a compound targeting the KRAS G12D mutation, demonstrates potent antitumor efficacy with an inhibitory concentration (IC50) of less than 500 nM.
价 格：￥电议型 号：T72394产 地：中国大陆
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T72355KRAS G12D inhibitor 16；化合物 KRAS G12D inhibitor 16KRAS G12D inhibitor 16
KRAS G12D Inhibitor 16 is a potent compound targeting the KRAS G12D and its mutation, exhibiting inhibitory activity with IC50 values of 0.7 nM and 0.35 μM, respectively. It is utilized in researching various malignant tumors including pancreatic ductal adenocarcinomas (PDAC), colon and rectal carcinomas (CRC), and non-small cell lung carcinomas (NSCLC).
价 格：￥电议型 号：T72355产 地：中国大陆
