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  • T36899INCB086550

    INCB086550 (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.

    价 格：￥电议型 号：T36899产 地：中国大陆

  • T7642CilostamideOPC-3689,OPC 3689,Cilostamide,Phosphodiesterase (PDE),Inhibitor,inhibit

    Cilostamide is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)

    价 格：￥电议型 号：T7642产 地：中国大陆

  • T13689Ethylene dimethanesulfonate

    Ethylene dimethanesulfonate has selective pro-apoptotic effects on LCs.?Ethylene dimethanesulfonate is a mild alkylating, non-volatile methanesulfonic diester of ethylene glycol.?

    价 格：￥电议型 号：T13689产 地：中国大陆

  • T83689Histatin 8 TFA；化合物 Histatin 8 TFAHst-8；Hst-8

    Histatin 8, a salivary antimicrobial peptide derived from proteolytic fragments of histatin 3 and histatin 5, exhibits activity against A. baumannii strains, both colistin-susceptible and -resistant, at a concentration of 32 ?g/ml. Additionally, it is effective against C. albicans and C. tropicalis, with minimum inhibitory concentrations (MICs) of 1 and 5 mg/ml, respectively.

    价 格：￥电议型 号：T83689产 地：中国大陆

  • T7642Cilostamide；OPC 3689 西洛酰胺OPC3689；OPC3689|||OPC 3689 西洛酰胺

    Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)

    价 格：￥电议型 号：T7642产 地：中国大陆

  • T73689Daclizumab；达昔单抗Ro 24-7375|||Zenapax；Ro 24-7375|||Zenapax

    Daclizumab (Zenapax) is a humanized monoclonal antibody that specifically inhibits the alpha subunit of IL-2R-HA. Daclizumab (Zenapax) can inhibit the binding of IL-2 and IL-2R-HA through specific binding to CD25. Daclizumab (Zenapax) studies multiple sclerosis.

    价 格：￥电议型 号：T73689产 地：中国大陆

  • T63689Aβ-IN-2；化合物 Aβ-IN-2Aβ-IN-2

    Aβ-IN-2 is a peptide inhibitor of Aβ1-42. Aβ-IN-2 inhibits the in vitro self-aggregation of Aβ1-42 by delaying the growth phase of the Aβ1-42 index or by reducing the number of protofibrils in the steady state.

    价 格：￥电议型 号：T63689产 地：中国大陆

  • T3689LRuboxistaurin mesylate；化合物 T3689LLY-333531|||LY333531|||LY 333531|||LY-333531 Mesylate；LY-333531|||L

    Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways. Ruboxistaurin inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.

    价 格：￥电议型 号：T3689L产 地：中国大陆

  • T36899INCB086550；化合物INCB086550PD-1/PD-L1-IN-8；PD-1/PD-L1-IN-8

    INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.

    价 格：￥电议型 号：T36899产 地：中国大陆

  • T36898Sandacanol；2-亚龙脑烯基丁醇Sandranol|||2-Ethyl-4-(2,2,3-trimethylcyclopent-3-en-yl)-but-2-en-1-ol；Sandranol

    Sandacanol（Sandranol） is a selective olfactory receptor (OR10H1) agonist. Sandacanol can induce cell cycle arrest and partial apoptosis in bladder cancer cells, and can reduce cell migration rate and proliferation rate.

    价 格：￥电议型 号：T36898产 地：中国大陆

  • T36897S65487；S65487S65487

    S65487 (VOB560) is a potent and selective Bcl-2 inhibitor. S65487 is also active on BCL-2 mutations, such as G101V and D103Y. S65487 has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 induces apoptosis and has anticaner activities[1][2].

    价 格：￥电议型 号：T36897产 地：中国大陆

  • T368966α-hydroxy Paclitaxel；6-羟基泰素6alpha-hydroxypaclitaxel；6alpha-hydroxypaclitaxel

    6α-hydroxy Paclitaxel (6α-OH-PTX) is a major metabolite of the anticancer compound paclitaxel and is partially cytotoxic.

    价 格：￥电议型 号：T36896产 地：中国大陆

  • T368955-Fluorouracil-13C,15N2；5-Fluorouracil-13C,15N25-Fluorouracil-13C,15N2；5-Fluorouracil-13C,15N2

    5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis.

    价 格：￥电议型 号：T36895产 地：中国大陆

  • T368945-Bromouridine；5-Bromouridine5-Bromouridine

    5-Bromouridine is a brominated analog of the nucleoside uridine .1It can be incorporated into RNA and subsequently detected by antibodies against bromodeoxyuridine .25-Bromouridine decreases the viability of HL-60 and MOLT-4 cells (LC50s = 10 and 20 μM, respectively). It induces apoptosis and halts the cell cycle at the S phase in HL-60 cells. It is photoreactive, and UV irradiation has been used to cross-link RNA containing 5-bromouridine to proteins in the study of of RNA-protein interactions.

    价 格：￥电议型 号：T36894产 地：中国大陆

  • T368934-oxo Withaferin A4-oxo Withaferin A4 oxo Withaferin A|||4oxo Withaferin A

    4-oxo Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells and carboplatin-resistant A2780 (A2780/CP70) cells (IC50s = 7.3 and <1 μM, respectively) and is 4.4-fold selective for A2780 cells over non-cancerous ARPE19 cells.

    价 格：￥电议型 号：T36893产 地：中国大陆

  • T36891MRIA9；化合物 MRIA9MRIA9

    MRIA9, an ATP-competitive inhibitor targeting pan Salt-Inducible Kinases (SIK) and PAK2/3, demonstrates IC50 values of 516 nM, 180 nM, and 127 nM for SIK1, SIK2, and SIK3, respectively [1].

    价 格：￥电议型 号：T36891产 地：中国大陆

  • T36890A 410099.1；A 410099.1A 410099.1

    High affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells.

    价 格：￥电议型 号：T36890产 地：中国大陆

  • T3689Ruboxistaurin hydrochloride；芦布妥林Ruboxistaurin|||LY333531 HCl|||LY 333531 hydrochloride；Ruboxistaurin

    Ruboxistaurin hydrochloride (LY 333531 hydrochloride) is an Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKCβ over other PKC isozymes (IC50values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 μM for PKCη, -δ, -γ, -α, -ε and -ζ respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src).

    价 格：￥电议型 号：T3689产 地：中国大陆

  • T33689Nitroparacetamol；化合物 T33689NCX 701|||NCX-701|||NCX701；NCX 701|||NCX-701|||NCX701

    Nitroparacetamol is nitric oxide (NO) donor and may be used to treat pain.

    价 格：￥电议型 号：T33689产 地：中国大陆

  • T33015LY-368975 hydrochloride；化合物 T33015LY-368975 hydrochloride

    LY-368975 hydrochloride is a bioactive chemical.

    价 格：￥电议型 号：T33015产 地：中国大陆

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