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T83888(S)-5-hydroxy-6-methoxy Duloxetine maleate；化合物 (S)-5-hydroxy-6-methoxy Duloxetine maleate(S)-5-hydro
(S)-5-hydroxy-6-methoxy Duloxetine, an active metabolite of the (S)-duloxetine, functions as a serotonin (5-HT) and norepinephrine reuptake inhibitor. Its formation occurs through the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2D6 via a 5- or 6-hydroxy duloxetine intermediate, followed by a catechol duloxetine intermediate. This compound effectively inhibits the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) across lipid membranes, with inhibitio
价 格：￥电议型 号：T83888产 地：中国大陆
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T372115-hydroxy-6-methoxy (S)-Duloxetine；5-hydroxy-6-methoxy (S)-Duloxetine5-hydroxy-6-methoxy (S)-Duloxet
5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine . It is formed from (S)-duloxetine via a 5- or 6-hydroxy duloxetine intermediate, which is formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2D6, and a catechol duloxetine intermediate. 5-hydroxy-6-methoxy (S)-Duloxetine binds to the serotonin (5-HT), norepinephrine, and dopamine transporters with Ki values of 266, 920, and 2,814 nM, respectively.
价 格：￥电议型 号：T37211产 地：中国大陆
