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T67843GSK215GSK215
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4). GSK215 is designed by the FAK inhibitor VS-4718 and a binder for the VHL E3 ligase. GSK215 can induce rapid and prolonged FAK degradation.
价 格:¥电议型 号:T67843产 地:中国大陆
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TN1684Ginsenoside F5Ginsenoside F-5,inhibit,Ginsenoside F5,leukemia,Ginsenoside F 5,Inhibitor,Apoptosis,pr
Ginsenoside F5 is a natural product from Panax ginseng C. A. Mey, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway
价 格:¥电议型 号:TN1684产 地:中国大陆
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T8699GFT505GFT505,GFT-505
GFT505 (Elafibranor) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.
价 格:¥电议型 号:T8699产 地:中国大陆
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T7388GSK805GSK 805,immunity,RAR-related orphan receptor,Inhibitor,GSK805,inhibit,ROR,oral,CNS penetrant,G
GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor´s putative ligand binding domain without exerting significant effects on DNA binding
价 格:¥电议型 号:T7388产 地:中国大陆
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T8845UTL-5gliver,inhibit,Inhibitor,chemoprotective,Tumor Necrosis Factor Receptor,radioprotective,acute,t
UTL-5g is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hematotoxicity. It lowers elevated levels of AST, ALT, creatinine, BUN, and TNF-α, increases the reduced platelet count in mice, and acts as a novel chemo- and radioprotective agent.
价 格:¥电议型 号:T8845产 地:中国大陆
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T7428SBI-115G protein-coupled Bile Acid Receptor 1,GPCR19,TGR5,SBI115,GPBAR1,Inhibitor,SBI-115,SBI 115,G-
SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5
价 格:¥电议型 号:T7428产 地:中国大陆
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T67741SU0561,3Dioxolo[4,5g]furo[3,4b]quinolin8(5H)one,9(3fluorophenyl)6,9dihydro5(2hydroxyethyl)
SU056 is a YB-1 inhibitor. SU056 interacts with YB-1 and inhibits and downstream proteins and pathways. SU056 can induce cell-cycle arrest, apoptosis, and inhibit cell migration in ovarian cancer cells.
价 格:¥电议型 号:T67741产 地:中国大陆
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T7300GDC-0575GDC 0575,GDC-0575,RG-7741,inhibit,ARRY575,Inhibitor,Checkpoint Kinase (Chk),ARRY 575,GDC0575
GDC-0575 is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).
价 格:¥电议型 号:T7300产 地:中国大陆
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T4488GSK-25GSK25;GSK 25
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).
价 格:¥电议型 号:T4488产 地:中国大陆
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T2039GSK-923295GSK923295
GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).
价 格:¥电议型 号:T2039产 地:中国大陆
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T1945GNE-7915GNE7915
GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
价 格:¥电议型 号:T1945产 地:中国大陆
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T1803GNF-5GNF 5;GNF5
GNF-5 is a specific non-ATP competitive inhibitor of Bcr-Abl (IC50: 0.22±0.1 uM, Wild-type Abl). It is an analog of GNF-2 with improved pharmacokinetic properties.
价 格:¥电议型 号:T1803产 地:中国大陆
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T1770GNE-9605GNE9605
GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
价 格:¥电议型 号:T1770产 地:中国大陆
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T11342LG-5555G-5555
G-5555 is a potent inhibitor of p21-activated kinase 1 (PAK1) (Kis: 3.7 nM and 11 nM for PAK1 and PAK2, respectively).
价 格:¥电议型 号:T11342L产 地:美洲
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T11411GLPG1205GLPG1205
GLPG1205 is potent, selective and orally active GPR84 (a G-protein-coupled receptor) antagonist with a favorable PK/PD profile.?GLPG1205 has anti-inflammatory activity and is used for the treatment of pulmonary fibrosis.?
价 格:¥电议型 号:T11411产 地:美洲
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T11477GSK1059865GSK1059865
GSK1059865 is a potent orexin 1 receptor antagonist.
价 格:¥电议型 号:T11477产 地:美洲
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T11480GSK205GSK205
GSK205 is a potent, selective TRPV4 antagonist with an IC50 of 4.19? μM for inhibiting TRPV4-mediated Ca2+ influx.?
价 格:¥电议型 号:T11480产 地:美洲
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T11500GSK3368715GSK3368715,EPZ019997,
GSK3368715 produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity. GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (P
价 格:¥电议型 号:T11500产 地:美洲
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T15434GSK2798745GSK2798745
GSK2798745 is used in research for the treatment of pulmonary edema associated with congestive heart failure. GSK2798745 is a selective and orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s of 1.8 and 1.6 nM for hTR
价 格:¥电议型 号:T15434产 地:美洲