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  • T82936ATX-II TFA；化合物 ATX-II TFAATX-II TFA

    ATX-II TFA, a specific Na+ channel modulator toxin, is derived from the venom of the sea anemone (Anemonia sulcata). This compound impedes the inactivation of Na+ channels and has been associated with arrhythmogenesis in the pulmonary vein and atrial fibrillation [1] [2]. It interacts with halothane, caffeine, and ryanodine in this modulation.

    价 格：￥电议型 号：T82936产 地：中国大陆

  • T80843Wasabi Receptor Toxin；化合物 Wasabi Receptor ToxinWaTx；WaTx

    Wasabi Receptor Toxin (WaTx) activates TRPA1 through prolonged channel openings while reducing Ca2+ permeability. This compound has potential applications in studying both acute and persistent pain [1].

    价 格：￥电议型 号：T80843产 地：中国大陆

  • T80039ATX-II；化合物 ATX-IIATX-II

    ATX-II, an Na+ channel modulator toxin derived from the sea anemone (Anemonia sulcata), causes delayed inactivation of the Na+ channels and has been linked to pulmonary vein arrhythmogenesis and atrial fibrillation [1] [2]. It exhibits interaction with halothane, caffeine, and ryanodine.

    价 格：￥电议型 号：T80039产 地：中国大陆

  • T72681ATX inhibitor 17；化合物 ATX inhibitor 17ATX inhibitor 17

    ATX inhibitor 17, a powerful ATX inhibitor, exhibits an IC50 value of 0.019 ?M, demonstrating significant anti-proliferative effects in breast cancer cells.

    价 格：￥电议型 号：T72681产 地：中国大陆

  • T64210ATX inhibitor 13；化合物 ATX inhibitor 13ATX inhibitor 13

    ATX inhibitor 13 (compound 10c) is an orally active ATX inhibitor (IC50: 3.4 nM). ATX inhibitor 13 is capable of blocking the cell cycle of RAW264.7 cells in the G2 phase, inhibiting cell proliferation and migration and inducing apoptosis. ATX inhibitor 13 exhibited an inhibitory effect on tumour colony formation.

    价 格：￥电议型 号：T64210产 地：中国大陆

  • T64141ATX inhibitor 11；化合物 ATX inhibitor 11ATX inhibitor 11

    ATX inhibitor 11 is a potent inhibitor of ATX (autotaxin) (IC50: 2.7 nM). ATX inhibitor 11 alleviates the severity of fibrotic tissue and effectively reduces the deposition of α-SMA, a biomarker of fibrosis, in a mouse model of fibrosis. ATX inhibitor 11 can be used to study lung fibrosis.

    价 格：￥电议型 号：T64141产 地：中国大陆

  • T64130ATX inhibitor 16；化合物 ATX inhibitor 16ATX inhibitor 16

    ATX inhibitor 16 is a potent inhibitor of ATX (IC50: 0.0021 μM). ATX inhibitor 16 exhibits a significant anti-proliferative effect on breast cancer cells.

    价 格：￥电议型 号：T64130产 地：中国大陆

  • T63904ATX inhibitor 19；化合物 ATX inhibitor 19ATX inhibitor 19

    ATX inhibitor 19 is a potent inhibitor of ATX (IC50: 156 nM).

    价 格：￥电议型 号：T63904产 地：中国大陆

  • T63845ATX inhibitor 14；化合物 ATX inhibitor 14ATX inhibitor 14

    ATX inhibitor 14, an indole-based carbamate derivative, is a potent inhibitor (IC50: 0.41 nM) of self-adhesive proteins (ATX) and has shown potential for research in fibrosis-related diseases.

    价 格：￥电议型 号：T63845产 地：中国大陆

  • T63829ATX inhibitor 20；化合物 ATX inhibitor 20ATX inhibitor 20

    ATX inhibitor 20 is a potent inhibitor of ATX (IC50: 2.3 nM).

    价 格：￥电议型 号：T63829产 地：中国大陆

  • T63612ATX inhibitor 8；化合物 ATX inhibitor 8ATX inhibitor 8

    ATX inhibitor 8 is an inhibitor of the autocrine motor factor Autotaxin (ATX).

    价 格：￥电议型 号：T63612产 地：中国大陆

  • T63584ATX inhibitor 12；化合物 ATX inhibitor 12ATX inhibitor 12

    ATX inhibitor 12 is an orally active ATX inhibitor (IC50: 1.72 nM). In C57Bl/6J mice, oral administration of ATX inhibitor 12 at a dose of 60 mg/kg was effective in inhibiting structural lung damage and reducing fibrotic lesions.

    价 格：￥电议型 号：T63584产 地：中国大陆

  • T63564ATX inhibitor 22；化合物 ATX inhibitor 22ATX inhibitor 22

    ATX inhibitor 22 is a novel inhibitor of ATX (autotaxin) (IC50: 218.9 μM) that lacks inhibitory activity against LPAR1.

    价 格：￥电议型 号：T63564产 地：中国大陆

  • T63524ATX inhibitor 10；化合物 ATX inhibitor 10ATX inhibitor 10

    ATX inhibitor 10 is a nitrogen-containing heterocyclic compound that is a potent inhibitor of ATX. Among other things, ATX plays a role in causing pathologies including fibrosis, neurodegeneration, arthritis, neuropathic pain, and cancer. ATX inhibitor 10 has shown research potential for ATX-related diseases.

    价 格：￥电议型 号：T63524产 地：中国大陆

  • T63510ATX inhibitor 21；化合物 ATX inhibitor 21ATX inhibitor 21

    ATX inhibitor 21 is a potent inhibitor of ATX (IC50: 3490 nM).

    价 格：￥电议型 号：T63510产 地：中国大陆

  • T63325ATX inhibitor 9；化合物 ATX inhibitor 9ATX inhibitor 9

    ATX inhibitor 9 is a thickened heteroaryl derivative compound and a potent inhibitor of ATX. Among them Autotaxin (ATX), also known as ENPP2, is a secreted enzyme highly expressed mainly in lung cancer cells, bronchial epithelial cells and alveolar macrophages.ATX inhibitor 9 has research potential for cancer or fibrous degenerative diseases.

    价 格：￥电议型 号：T63325产 地：中国大陆

  • T61612ATX inhibitor 15；化合物 ATX inhibitor 15ATX inhibitor 15

    ATX inhibitor 15 (compound 30) is an indole-based carbamate derivative with a strong inhibitory effect on autotaxin (ATX), demonstrated by an IC50 of 2.17 nM. Additionally, ATX inhibitor 15 effectively inhibits ATX activity in vivo and suppresses the expression of pro-fibrotic genes. Furthermore, ATX inhibitor 15 exhibits protective effects in lung fibrosis induced by Bleomycin in mice [1].

    价 格：￥电议型 号：T61612产 地：中国大陆

  • T39190ATX-002；ATX-002ATX-002

    ATX-002 is a property-tunable lipid for RNA drug delivery.

    价 格：￥电议型 号：T39190产 地：中国大陆

  • T39136ATX inhibitor 7；ATX inhibitor 7ATX inhibitor 7

    ATX inhibitor 7 is a autotaxin inhibitor and shows good oral exposure.

    价 格：￥电议型 号：T39136产 地：中国大陆

  • T17235Voclosporin；伏环孢素ISAtx-247；ISAtx-247

    Voclosporin (ISAtx-247) is a novel and orally available calcium-modulated phosphatase (CN; PP2B) inhibitor and immunosuppressant for the treatment of lupus nephritis.

    价 格：￥电议型 号：T17235产 地：中国大陆

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