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  • T11112DUB-IN-3

    DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c. The IC50 for USP8 is 0.56 μM.

    价 格：￥电议型 号：T11112产 地：中国大陆

  • T11112DUB-IN-3DUB-IN-3

    DUB-IN-3 is IC50 of 0.56 μM for USP8，is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c.

    价 格：￥电议型 号：T11112产 地：美洲

  • T78776DNA gyrase B-IN-3；化合物 DNA gyrase B-IN-3DNA gyrase B-IN-3

    DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against Gram-positive strains [1].

    价 格：￥电议型 号：T78776产 地：中国大陆

  • T78746Mtb-IN-3；化合物 Mtb-IN-3Mtb-IN-3

    Mtb-IN-3 (compound 10c), a selective and potent Mycobacterium tuberculosis (Mtb) inhibitor, exhibits strong antimycobacterial activity in vitro without inducing cytotoxic effects and inhibits colony formation in the spleen in murine tuberculosis models [1].

    价 格：￥电议型 号：T78746产 地：中国大陆

  • T78648MAO-B-IN-3；化合物 MAO-B-IN-3MAO-B-IN-3

    MAO-B-IN-3 is a reversible, selective inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 96 nM and demonstrates affinity for the 5-HT6 receptor with a Ki of 696 nM, making it suitable for Alzheimer´s disease research [1].

    价 格：￥电议型 号：T78648产 地：中国大陆

  • T78232hMAO-B-IN-32；hMAO-B抑制剂32Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate；Ethyl 7-(diethylamino

    hMAO-B-IN-32 is a potent hMAO-B selective inhibitor with an IC50 of 45.52 μM.

    价 格：￥电议型 号：T78232产 地：中国大陆

  • T74991Dual AChE-MAO B-IN-3；化合物 Dual AChE-MAO B-IN-3Dual AChE-MAO B-IN-3

    Dual AChE-MAO B-IN-3 (Compound C10) is a potent inhibitor of both AChE and MAO-B, exhibiting IC50 values of 0.58 μM and 0.41 μM, respectively. This dual-binding inhibitor targets the catalytic anionic site and peripheral anionic site of AChE, making it relevant for Alzheimer’s disease (AD) research [1].

    价 格：￥电议型 号：T74991产 地：中国大陆

  • T74828AcrB-IN-3；化合物 AcrB-IN-3AcrB-IN-3

    Efflux pump-IN-3, an AcrB efflux pump inhibitor, potentiates the effect of antibiotics by inhibiting the efflux of Nile Red (a known substrate of AcrB). It does not disrupt the bacterial outer membrane or exhibit toxicity in a nematode model [1].

    价 格：￥电议型 号：T74828产 地：中国大陆

  • T72791AChE/MAO-B-IN-3；化合物 AChE/MAO-B-IN-3AChE/MAO-B-IN-3

    AChE/MAO-B-IN-3 is a dual inhibitor targeting both acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B), exhibiting inhibitory concentrations (IC50s) of 0.0257 μM and 0.0456 μM against human AChE and MAO-B, respectively. This compound holds potential for Alzheimer’s disease research.

    价 格：￥电议型 号：T72791产 地：中国大陆

  • T72453AChE/BChE/MAO-B-IN-3；化合物 AChE/BChE/MAO-B-IN-3AChE/BChE/MAO-B-IN-3

    AChE/BChE/MAO-B-IN-3, an indan-1-one derivative, serves as a potent inhibitor of human monoamine oxidase B (MAO-B) with an IC50 of 0.0359 μM, demonstrating significant inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 0.0473 μM and 0.0782 μM, respectively. Exhibiting notable antioxidant activity, AChE/BChE/MAO-B-IN-3 holds considerable promise for Alzheimer´s disease (AD) research.

    价 格：￥电议型 号：T72453产 地：中国大陆

  • T64005PDE4B-IN-3；化合物 PDE4B-IN-3PDE4B-IN-3

    PDE4B-IN-3 is a potent inhibitor of PDE4B (IC50: 0.94 μM) and exhibits anti-inflammatory effects.

    价 格：￥电议型 号：T64005产 地：中国大陆

  • T63790Cbl-b-IN-3；化合物Cbl-b-IN-3Cbl-b-IN-3

    Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b negatively regulates p85 in an independent proteolytic manner, and participates in the recruitment of p85 to CD28 and T cell antigen receptor ζ through its E3 ubiquitin ligase activity. Inhibition of PI3K inhibits the enhancement of Cblb-/ -T cell activation.

    价 格：￥电议型 号：T63790产 地：中国大陆

  • T62875NF-κB-IN-3；化合物 NF-κB-IN-3NF-κB-IN-3

    NF-κB-IN-3 (Compound 2) is an NF-κB inhibitor (IC50: 0.70 μM) and can be used as an anti-tumour agent.

    价 格：￥电议型 号：T62875产 地：中国大陆

  • T62276Factor B-IN-3；化合物 Factor B-IN-3Factor B-IN-3

    Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases.

    价 格：￥电议型 号：T62276产 地：中国大陆

  • T61851PTP1B-IN-3 diammonium；化合物 PTP1B-IN-3 diammoniumPTP1B-IN-3 diammonium

    PTP1B-IN-3 diammonium is a highly effective and orally bioavailable inhibitor of the protein tyrosine phosphatase 1B (PTP1B) enzyme, with an IC50 value of 120 nM for both PTP1B and TCPTP. This compound exhibits potent antidiabetic and anticancer properties, as supported by extensive research [1] [2].

    价 格：￥电议型 号：T61851产 地：中国大陆

  • T61771KDM2B-IN-3；化合物 KDM2B-IN-3KDM2B-IN-3

    KDM2B-IN-3 is a potent inhibitor of the histone demethylase KDM2B. It holds promise for cancer research applications [1].

    价 格：￥电议型 号：T61771产 地：中国大陆

  • T61565KDM5B-IN-3；化合物 KDM5B-IN-3KDM5B-IN-3

    KDM5B-IN-3 (Compound 5) is an inhibitor of histone lysine-specific demethylase 5B (KDM5B) or JARID1B. It effectively inhibits the activity of KDM5B with an IC50 value of 9.32 μM. Consequently, KDM5B-IN-3 serves as a valuable tool in gastric cancer research [1].

    价 格：￥电议型 号：T61565产 地：中国大陆

  • T61002hMAO-B-IN-3；化合物 hMAO-B-IN-3hMAO-B-IN-3

    hMAO-B-IN-3 (Compound 15) is a potent hMAO-B inhibitor (IC 50 = 47.4 nM) with favourable drug-like properties and a broad safety window. Therefore, hMAO-B-IN-3 is a suitable candidate for lead optimization and multitarget-directed ligands development [1].

    价 格：￥电议型 号：T61002产 地：中国大陆

  • T11112DUB-IN-3；化合物DUB-IN-3DUB-IN-3

    DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.

    价 格：￥电议型 号：T11112产 地：中国大陆

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