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T39957CDK4/6-IN-6
CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.
价 格：￥电议型 号：T39957产 地：中国大陆
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T2381AbemaciclibLY2835219；CDK4/6 dual inhibitor
LY2835219 is an effective and specific CDK4/6 inhibitor (IC50: 2/10 nM).
价 格：￥电议型 号：T2381产 地：中国大陆
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T2381AbemaciclibAbemaciclib,LY2835219,CDK4/6 dual inhibitor
LY2835219 is an effective and specific CDK4/6 inhibitor (IC50: 2/10 nM).
价 格：￥电议型 号：T2381产 地：美洲
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T79112CDK4/6-IN-17；化合物 CDK4/6-IN-17CDK4/6-IN-17
CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells. It has shown efficacy in inhibiting tumor growth in the COLO205 xenograft model [1].
价 格：￥电议型 号：T79112产 地：中国大陆
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T75029HEMTAC CDK4/6 degrader 1；化合物 HEMTAC CDK4/6 degrader 1HEMTAC CDK4/6 degrader 1
HEMTAC CDK4/6 degrader 1 is a PROTAC connected by ligands for HSP90 and CDK4/6 with a K d value of 35.7 μM. HEMTAC CDK4/6 degrader 1 induces CDK4/6 degradation in B16F10 melanoma cells. HEMTAC CDK4/6 degrader 1 arrests cell cycle at G0/G1 phase and induces apoptosis . HEMTAC CDK4/6 degrader 1 can be used in research of cancer [1] .
价 格：￥电议型 号：T75029产 地：中国大陆
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T74370CDK4/6-IN-11；化合物 CDK4/6-IN-11CDK4/6-IN-11
CDK4/6-IN-11 is a potent PROTAC CDK4/6 degrader.
价 格：￥电议型 号：T74370产 地：中国大陆
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T72951CDK4/6-IN-14；化合物 CDK4/6-IN-14CDK4/6-IN-14
CDK4/6-IN-14 is a potent, highly selective inhibitor of Cyclin-Dependent Kinases 4 and 6 (CDK4/6), demonstrating inhibition concentrations (IC50s) of 10 nM and 16 nM, respectively. It possesses over 60-fold greater selectivity for CDK4/6 compared to CDKs 1, 2, 7, and 9, and exhibits significant selectivity against a panel of 205 other kinases.
价 格：￥电议型 号：T72951产 地：中国大陆
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T72928CDK4/6-IN-15；化合物 CDK4/6-IN-15CDK4/6-IN-15
CDK4/6-IN-15, an orally active and selective inhibitor of CDK4/6, effectively halts the growth of cancer cells by arresting the cell cycle at the G1 phase and inhibiting the phosphorylation of the retinoblastoma tumor suppressor protein (Rb) at S780, as well as suppressing E2 factor (E2F)-regulated gene expression.
价 格：￥电议型 号：T72928产 地：中国大陆
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T67780AM5992；化合物AM5992CDK4/6-IN-16；CDK4/6-IN-16
AM5992 (example 195) is a potent CDK4 and CDK6 inhibitor (CDK4, IC50= 0.013 μM). AM5992 can be used for the research of CDK4-mediated disorders.
价 格：￥电议型 号：T67780产 地：中国大陆
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T64244CDK4/6-IN-10；化合物 CDK4/6-IN-10CDK4/6-IN-10
CDK4/6-IN-10 is a selective, potent, orally active inhibitor of CDK4 (IC50: 22 nM) and CDK6 (IC50: 10 nM) with antitumour effects. CDK4/6-IN-10 has potential for studies in multiple myeloma (MM).
价 格：￥电议型 号：T64244产 地：中国大陆
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T62605CDK4/6-IN-13；化合物 CDK4/6-IN-13CDK4/6-IN-13
Compounds 10B and 10C, functioning as cdk4/6 inhibitors, demonstrated low nanomolar activity, optimal antiproliferative effects, excellent metabolic properties, and acceptable pharmacokinetics targeting cdk4/6.
价 格：￥电议型 号：T62605产 地：中国大陆
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T62192CDK4/6-IN-9；化合物 CDK4/6-IN-9CDK4/6-IN-9
CDK4/6-IN-9 (compound 10) is a selective inhibitor of CDK4/6, capable of acting on CDK6/cyclin D1 (IC50: 905 nM). CDK4/6-IN-9 has potential research value in multiple myeloma (MM).
价 格：￥电议型 号：T62192产 地：中国大陆
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T61892CDK4/6-IN-8；化合物 CDK4/6-IN-8CDK4/6-IN-8
CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).
价 格：￥电议型 号：T61892产 地：中国大陆
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T61738CDK4/6-IN-7；化合物 CDK4/6-IN-7CDK4/6-IN-7
CDK4/6-IN-7, a highly potent and selective orally active inhibitor of CDK4/6, demonstrates impressive inhibition activity with IC50 values of 1.58 nM and 4.09 nM respectively. This compound is particularly valuable for breast cancer research [1].
价 格：￥电议型 号：T61738产 地：中国大陆
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T60328CDK4/6-IN-12；化合物 CDK4/6-IN-12CDK4/6-IN-12
CDK4/6-IN-12 is a potent cyclin-dependent kinase 4/6 (CDK4/6) inhibitor. CDK4/6-IN-12 has enzymatic inhibitory activity against CDK4 and CDK6 with IC 50 of 592.3 nM and 3090 nM, respectively. CDK4/6-IN-12 can be used in the cancer research[1].
价 格：￥电议型 号：T60328产 地：中国大陆
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T39957CDK4/6-IN-6；化合物CDK4/6-IN-6CDK4/6-IN-6
CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.
价 格：￥电议型 号：T39957产 地：中国大陆
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T39956CDK4/6-IN-5CDK4/6-IN-5CDK4/6-IN-5
CDK4/6-IN-5 is a highly effective inhibitor of CDK4 and CDK6, with Ki values of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively (WO2019207463A1, example A93).
价 格：￥电议型 号：T39956产 地：中国大陆
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T2381Abemaciclib；化合物AbemaciclibCDK4/6 dual inhibitor|||LY2835219；CDK4/6 dual inhibitor|||LY2835219
Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity. Abemaciclib has antitumor activity and is used to treat advanced or metastatic breast cancer.
价 格：￥电议型 号：T2381产 地：中国大陆
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T21720GP-82996；化合物GP-82996Cdk4/6 Inhibitor IV|||CINK4；Cdk4/6 Inhibitor IV|||CINK4
GP-82996 (CINK4) is a pharmacological inhibitor specifically targeting CDK4/6, exhibiting IC50 values of 1.5 μM for CDK4/cyclin D1, 5.6 μM for CDK6/cyclin D1, and 25 μM for Cdk5/p35. It effectively induces apoptosis in U2OS cancer cells, positioning it as a potential investigational tool in cancer research [1] [2].
价 格：￥电议型 号：T21720产 地：中国大陆
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T10737CDK4/6-IN-3；化合物 T10737CDK4/6-IN-3
CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.
价 格：￥电议型 号：T10737产 地：中国大陆
