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T82392FLT3-IN-23；化合物 FLT3-IN-23FLT3-IN-23
FLT3-IN-23 (compound 15), a potent inhibitor of FMS-like tyrosine kinase 3 (FLT3), exhibits an IC 50 value of 7.42 nM and demonstrates antiproliferative effects against BaF3 cells harboring diverse FLT3-TKD and FLT3-ITD-TKD mutations [1].
价 格：￥电议型 号：T82392产 地：中国大陆
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T79596FLT3-IN-20；化合物 FLT3-IN-20FLT3-IN-20
FLT3-IN-20 (compound 34f) is a potent FLT3 inhibitor, demonstrating IC50 values of 1 nM for FLT3-D835Y and 4 nM for FLT3-ITD. It exhibits anti-proliferative effects on FLT3-ITD-positive AML cell lines, with IC50s of 7 nM in MV4-11 and 9 nM in MOLM-13, as well as 4 nM in a MOLM-13 variant harboring the FLT3-ITD-D835Y mutation. FLT3-IN-20 is utilized in cancer research [1].
价 格：￥电议型 号：T79596产 地：中国大陆
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T79420FLT3-IN-22；化合物 FLT3-IN-22FLT3-IN-22
FLT3-IN-22 (compound 22f) is a potent inhibitor of FLT3, demonstrating IC50 values of 0.941 nM for FLT3 and 0.199 nM for the FLT3/D835Y mutant. This compound displays significant antiproliferative effects against MV4-11 cells and Ba/F3 cell lines expressing mutant FLT kinase variants, such as FLT-D835Y and FLT3-F691L [1].
价 格：￥电议型 号：T79420产 地：中国大陆
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T79391FLT3-IN-21；化合物 FLT3-IN-21FLT3-IN-21
FLT3-IN-21 (compound LC-3), a potent FLT3 inhibitor with an IC50 value of 8.4 nM, induces apoptosis and arrests the cell cycle in the G1 phase. It effectively inhibits the proliferation of FLT3-ITD-positive AML cells MV-4-11, with an IC50 of 5.3 nM. In murine models, a daily dose of 10 mg/kg FLT3-IN-21 markedly inhibited tumor growth in the MV-4-11 xenograft model, achieving a tumor growth inhibition (TGI) of 92.16% [1].
价 格：￥电议型 号：T79391产 地：中国大陆
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T1938FLT3-IN-2；化合物FLT3-IN-2FLT3-IN-2
FLT3-IN-2 is an FLT3 inhibitor (IC50<1 μM).
价 格：￥电议型 号：T1938产 地：中国大陆
