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  • T82341Ganglioside GM1；化合物 Ganglioside GM1Ganglioside GM1

    Ganglioside GM1, a member of the ganglioside family, serves as a functional tissue receptor for Cholera Toxin1 [1] and is utilized in neurological disease research.

    价 格：￥电议型 号：T82341产 地：中国大陆

  • T82340Ganglioside GM2；化合物 Ganglioside GM2Ganglioside GM2

    Ganglioside GM2, a human tumor antigen (OFA-I-1), is the primary lysosomal storage compound in Tay-Sachs disease [1] [2].

    价 格：￥电议型 号：T82340产 地：中国大陆

  • T82277GM1a Ganglioside oligosaccharide；化合物 GM1a Ganglioside oligosaccharideGM1a Ganglioside oligosaccharid

    GM1a Ganglioside oligosaccharide, a semisynthetic derivative of ganglioside GM1, serves as the natural receptor for cholera toxin and is crucial for both general growth regulation and the coupling of hormone-induced responses [1].

    价 格：￥电议型 号：T82277产 地：中国大陆

  • T75410Ganglioside sialidase (AuSialidase S)；化合物 Ganglioside sialidase (AuSialidase S)Ganglioside sialidase

    Ganglioside sialidase (AuSialidase S), an endogenous metabolite, plays a critical role in neuronal differentiation, specifically in neurite outgrowth [1].

    价 格：￥电议型 号：T75410产 地：中国大陆

  • T40579Ganglioside GD3 disodium salt；Ganglioside GD3 disodium saltGanglioside GD3 disodium salt

    Ganglioside GD3 disodium salt is a melanoma-associated antigen often targeted in immune therapy for melanomas.

    价 格：￥电议型 号：T40579产 地：中国大陆

  • T38027Ganglioside GM2 Asialo Mixture；Ganglioside GM2 Asialo MixtureGanglioside GM2 Asialo Mixture；Ganglios

    Ganglioside GM2 asialo (asialo- GM2) is a glycosphingolipid containing three monosaccharide residues and a fatty acid of variable chain length but lacking the sialic acid residue present on ganglioside M2. Asialo-GM2 levels are low-to-undetectable in normal human brain, but it accumulates in the brain of patients with Tay-Sachs and Sandhoff disease, which are neurodegenerative disorders characterized by deficiency of lysosomal β-hexosaminidase A and B, respectively. It also binds to various bact

    价 格：￥电议型 号：T38027产 地：中国大陆

  • T37582Ganglioside GM1 Mixture (ovine) (ammonium salt)；Ganglioside GM1 Mixture (ovine) (ammonium salt)Gangl

    Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane.3It associates with growth factor receptors, including TrkA, TrkB, and the GDNF receptor complex containing Ret and GFRα, and is required for TrkA expression on the cell surface. Ganglioside GM1interacts with other proteins to increase calcium i

    价 格：￥电议型 号：T37582产 地：中国大陆

  • T37295Ganglioside GM1 Asialo Mixture；Ganglioside GM1 Asialo MixtureGanglioside GM1 Asialo Mixture

    Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody. The percentage of ganglioside GM1 asialo-positive na

    价 格：￥电议型 号：T37295产 地：中国大陆

  • T36862Ganglioside GT1b Mixture (sodium salt)；Ganglioside GT1b Mixture (sodium salt)Ganglioside GT1b Mixtur

    Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 μM, respectively.[1] Ganglioside GT1b-containing liposomes bind to the major coat protein VP1 from Merkel cell polyomavirus (MCPyV), which has been identified in Merkel cell carcinomas, identifying ganglioside GT1b as a putative MCP

    价 格：￥电议型 号：T36862产 地：中国大陆

  • T36861Ganglioside GD1b Mixture (sodium salt)；Ganglioside GD1b Mixture (sodium salt)Ganglioside GD1b Mixtur

    Ganglioside GD1b is an acidic glycosphingolipid that contains two sialic acid residues linked to an inner galactose unit. It is a component of plasma membranes where it packs densely with cholesterol to form lipid microdomains that modulate both intra- and intercellular signaling events. The concentration of ganglioside GD1b in human brain increases with age, constituting 7.85% of total sialic acid in the brain of 0- to 10-year-old subjects and 20.29% in 11- to 30-year-old subjects. Ganglioside

    价 格：￥电议型 号：T36861产 地：中国大陆

  • T36413N-glycolyl-Ganglioside GM3 Mixture (ammonium salt)；N-glycolyl-Ganglioside GM3 Mixture (ammonium salt

    N-glycolyl-Ganglioside GM3(NeuGc-GM3) is a form of ganglioside GM3 that contains an N-glycolylated sialic acid (NeuGc).

    价 格：￥电议型 号：T36413产 地：中国大陆

  • T35930Ganglioside GM2 Mixture (sodium salt)；Ganglioside GM2 Mixture (sodium salt)Ganglioside GM2 Mixture (

    Ganglioside GM2 is a glycosphingolipid component of cellular membranes, primarily the plasma membrane. Levels of ganglioside GM2 are elevated in the brain of patients with Sandhoff disease, as well as feline and mouse models of the disease. Ganglioside GM2 accumulates in the lysosomes of individuals with Tay-Sachs disease and GM2-activator deficiency, as well as in the CNS of patients with and animal models of mucopolysaccharide storage disorders and Niemann-Pick disease types A, C1, and C2. Gan

    价 格：￥电议型 号：T35930产 地：中国大陆

  • T35588Ganglioside GM3 Mixture (sodium salt)；Ganglioside GM3 Mixture (sodium salt)Ganglioside GM3 Mixture (

    Ganglioside GM3 is a monosialoganglioside that demonstrates antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation. It suppresses angiogenesis and reduces proliferation and migration of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 20 μM via inhibition of VEGFR2 and Akt phosphorylation. Ganglioside GM3 induces dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functi

    价 格：￥电议型 号：T35588产 地：中国大陆

  • T35587Ganglioside GD1a mixture (sodium salt)；Ganglioside GD1a mixture (sodium salt)Ganglioside B1；Ganglios

    Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver. [1] It can be shed from the surface of tumor cells into the microenvironment where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis. Ganglioside GD1a (20 μM) also increases endothelial cell proliferation. Furthermore, ganglioside GD1a has been shown to act as a functional coreceptor for toll-like receptor 2 (T

    价 格：￥电议型 号：T35587产 地：中国大陆

  • T35553Ganglioside GQ1b Mixture (sodium salt)；Ganglioside GQ1b Mixture (sodium salt)Ganglioside GQ1b Mixtur

    Ganglioside GQ1b is a tetrasialoganglioside that contains two sialic acid residues linked to an inner galactose unit. It stimulates phosphorylation of several ecto-type protein kinase substrates on the surface of GOTO human neuroblastoma cells when used at a concentration of 5 nM. Ganglioside GQ1b promotes differentiation of murine embryonic stem cells (mESCs) to neuronal precursor and glial cells via activation of the ERK1/2 pathway. It also induces differentiation of murine keratinocytes throu

    价 格：￥电议型 号：T35553产 地：中国大陆

  • T35552Ganglioside GD3 Mixture (sodium salt)；Ganglioside GD3 Mixture (sodium salt)Ganglioside GD3 Mixture (

    Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. It induces apoptosis in HuT-78 cutaneous T cell lymphoma cells in a concentration-dependent manner and disrupts the mitochondrial membrane potential when used at a concentration of 200 μM. Expression of ganglioside GD3 in GD3-negative SK-MEL-28-N1 malignant melanoma cells increa

    价 格：￥电议型 号：T35552产 地：中国大陆

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