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产品数：86101
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TN1438beta-Amyrin acetateHMG-CoA,betaAmyrin acetate,LDL,Fungal,inhibit,Inhibitor,arthritic,hemolysis,antif
beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, and anti-hyperlipidemic activities.
价 格：￥电议型 号：TN1438产 地：中国大陆
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T8595Practololreceptor,inhibit,arrhythmias,β1-adrenergic,Practolol,Beta Receptor,Adrenergic Receptor,card
Practolol is a selective β-adrenoceptor blocker.
价 格：￥电议型 号：T8595产 地：中国大陆
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T9428HM43239HM43239,HM-43239
HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. HM43239 directly inhibits the kinase activity of FLT3 as a reversible Type I inhibitor and effectively modulates downstream p-STAT5 and p-ERK. HM43239 also demonstrated inhibition of SYK, JAK1/2 and TAK1. HM43239 inhibits the proliferation and induces the apoptosis of leukemic cells [1] [2] [3].
价 格：￥电议型 号：T9428产 地：中国大陆
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T6476Dofetilidecardiovascular,potent,specific,class,antiarrhythmic,orally,Inhibitor,UK68789,UK-68789,Dofe
Dofetilide is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter.
价 格：￥电议型 号：T6476产 地：中国大陆
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T12902SHMT-IN-1SHMT IN 1,SHMTIN1
SHMT-IN-1 is a potent plasmodial serine hydroxymethyltransferase (SHMT) inhibitor with antitumor activity.
价 格：￥电议型 号：T12902产 地：中国大陆
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T4074GSK-872translocation,GSK-872,neurological,HMGB1,Receptor-interacting protein kinases,brain,GSK 872,c
GSK872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM).
价 格：￥电议型 号：T4074产 地：中国大陆
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T7025Rehmannioside DInhibitor,inhibit,Rehmannioside D
Rehmannioside D is a carotenoid glycoside that existed in the roots of Rehmannia glutinosa.
价 格：￥电议型 号：T7025产 地：中国大陆
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TN67157-KetocholesterolHMG-CoA reductase,inhibit,7 Ketocholesterol,Endogenous Metabolite,Inhibitor,coronar
7-Ketocholesterol is a metabolite of Cholesterol
价 格：￥电议型 号：TN6715产 地：中国大陆
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T9019JHU37152JHU37152,inhibit,hM3Dq,Clozapine,Inhibitor,DREADD,Muscarinic acetylcholine receptor,mAChR,hM
JHU 37152 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
价 格：￥电议型 号：T9019产 地：中国大陆
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T7813α-MSHMelanocortin Receptor,hormone,αMSH,inhibit,Inhibitor,α MSH,neuroimmunomodulatory,inflammation,e
α-MSH is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
价 格：￥电议型 号：T7813产 地：中国大陆
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T7837SR8278Duchenne muscular dystrophy,inhibit,metabolism,biological rhythm,Alzheimer’s disease,SR-8278,S
SR8278 is an REV-ERBα antagonist(EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112
价 格：￥电议型 号：T7837产 地：中国大陆
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T6541Ibutilide FumarateIbutilide,antiarrhythmia agent,Potassium Channel,inhibit,Inhibitor,long QT syndrom
Ibutilide Fumarate is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outward potassium currents. This results in prolongation of atrial and ventricular action potential duration and refractory periods. Ibutilide slightly decreases the sinus rate and atrioventricular (AV) conduction and produces a dose-related prolongation of the QT interval.
价 格：￥电议型 号：T6541产 地：中国大陆
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T6450ClinofibrateClinofibrate,HMG-CoA Reductase (HMGCR),Autophagy,inhibit,Inhibitor,S 8527,S8527
Clinofibrate（IC50 of 0.47 mM）, a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol and triacylglyceride levels in the blood.
价 格：￥电议型 号：T6450产 地：中国大陆
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T6445CilomilastCilomilast,asthma,immunomodulatory,obstructive,Inhibitor,Phosphodiesterase (PDE),inhibit,P
Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.
价 格：￥电议型 号：T6445产 地：中国大陆
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T10903CWHM-1552CWHM1552,CWHM 1552
CWHM-1552 is an effective Plasmodium falciparum inhibitor. For the 3D7 and Dd2 strains, the IC50s are 51 nM and 53 nM.
价 格：￥电议型 号：T10903产 地：中国大陆
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T9448IL-17A inhibitor 1inhibit,Inhibitor,Interleukin Related,COPD,Asthma,IL-17A inhibitor 1,IL17A inhibit
IL-17A inhibitor 1 is a IL-17A inhibitor with IC50 of <9.45 nM in alphalisa assay. IL-17A inhibitor 1 inhibits HT-29 cells with IC50 of 9.3 nM.
价 格：￥电议型 号：T9448产 地：中国大陆
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T9356(E/Z)-GO289Inhibitor,cancer,(E/Z)GO289,circadian,(E/Z)-GO-289,cell,clock,rhythms,growth,(E/Z) GO289,
(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E/Z)-GO289 exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function. The discovery of (E/Z)-GO289 provides a direct link between the circadian clock and cancer regulation and reveals unique design principles underlying kinase selectivity.
价 格：￥电议型 号：T9356产 地：中国大陆
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T6376Allopurinol Sodiumanti-nociception,HIF-2α,inhibit,anti-leishmanial,gout,hyperuricemia,HIF-1α,HUVEC c
Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
价 格：￥电议型 号：T6376产 地：中国大陆
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TQ0232UNC0646H3K9me2,KMT1D,chromatin,EHMT1,Histone Methyltransferase,UNC-0646,SAR,inhibit,G9a,GLP,PKMT,UNC
UNC 0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646 potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50: 4.7 μM in MCF7 cells).
价 格：￥电议型 号：TQ0232产 地：中国大陆
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T10802CHMFL-EGFR-202CHMFLEGFR202,CHMFL EGFR 202
CHMFL-EGFR-202 is a potent, irreversible inhibitor of EGFR mutant kinase (IC50s: 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases).
价 格：￥电议型 号：T10802产 地：中国大陆
