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  • T14860CaMKII-IN-1

    CaMKII-IN-1 is a potent and highly selective inhibitor of CaMKII (IC50 = 63 nM). CaMKII-IN-1 exhibited more than 100-fold higher selectivity for CaMKII over CaMKIV, MLCK, p38a, Akt1, and PKC.

    价 格：￥电议型 号：T14860产 地：中国大陆

  • T14860CaMKII-IN-1CaMKII-IN-1

    CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor (IC50: 63 nM). It has significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC.

    价 格：￥电议型 号：T14860产 地：美洲

  • T82758CDK9-Cyclin T1 PPI-IN-1；化合物 CDK9-Cyclin T1 PPI-IN-1CDK9-Cyclin T1 PPI-IN-1

    CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBC MDA-MB-231 cells with an IC50 of 0.044 μM and inducing apoptosis. This compound diminishes CDK9 transcriptional activity and downregulates phosphorylation of RNA Pol II CTD ser2. In vivo, CDK9-Cyclin T1 PPI-IN-1 effectively impedes tumor growth in a TNBC 4T1 mouse model [1].

    价 格：￥电议型 号：T82758产 地：中国大陆

  • T81373Proteasome β2c/i-IN-1；化合物 Proteasome β2c/i-IN-1Proteasome β2c/i-IN-1

    Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].

    价 格：￥电议型 号：T81373产 地：中国大陆

  • T80697β5i-IN-1；化合物 β5i-IN-1β5i-IN-1

    β5i-IN-1 is a selective inhibitor of β5i, exhibiting potent activity with an IC50 of 8.463 nM. It modulates immune responses by promoting the release of TNF-α and IL-6 and affecting NF-κB transcriptional activity. This compound has applications in the research of idiopathic pulmonary fibrosis [1].

    价 格：￥电议型 号：T80697产 地：中国大陆

  • T79457PEX5-PEX14 PPI-IN-1；化合物 PEX5-PEX14 PPI-IN-1PEX5-PEX14 PPI-IN-1

    PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor that disrupts the interaction between PEX5 and TbPEX14 with an inhibitory constant (Ki) of 53 μM. It effectively inhibits the bloodstream form of Trypanosoma brucei brucei, with a half-maximal effective concentration (EC50) of 5 μM [1].

    价 格：￥电议型 号：T79457产 地：中国大陆

  • T78729hCAIX/VII-IN-1；化合物 hCAIX/VII-IN-1hCAIX/VII-IN-1

    hCAIX/VII-IN-1 is a selective inhibitor of human carbonic anhydrase isoforms VII and IX. It displays inhibitory activity against hCA I, II, IV, VII, and IX, with respective K_i values of 336.2 nM, 185.8 nM, 1055 nM, 35.6 nM, and 28.0 nM. This compound is applicable in cancer and neurological disease research [1].

    价 格：￥电议型 号：T78729产 地：中国大陆

  • T74978DPP IV/hCA II-IN-1；化合物 DPP IV/hCA II-IN-1DPP IV/hCA II-IN-1

    DPP IV/hCA II-IN-1 is a potent, selective inhibitor of dipeptidyl peptidase IV (DPP IV) and carbonic anhydrase (CA), exhibiting an IC50 of 0.049 μM for DPP IV and K_i values of 0.0361, 0.0428, 0.0941, 0.1328, 0.2615, and 3.034 μM for CA II, CA VB, CA VA, CA IX, CA I, and CA IV, respectively [1].

    价 格：￥电议型 号：T74978产 地：中国大陆

  • T74630RNA polymerase II-IN-1；化合物 RNA polymerase II-IN-1RNA polymerase II-IN-1

    RNA polymerase II-IN-1 (compound 19iv), an amatoxin, selectively inhibits RNA polymerase II (Pol II) with an IC50 of 36.66 nM. It exhibits heightened cytotoxicity towards cancer cells and reduced toxicity in normal cells compared to α-Amanitin [1].

    价 格：￥电议型 号：T74630产 地：中国大陆

  • T73033TRK II-IN-1；化合物 TRK II-IN-1TRK II-IN-1

    TRK II-IN-1 is a potent type II inhibitor of tropomyosin receptor kinases (TRK), demonstrating inhibitory half-maximal inhibitory concentrations (IC50s) of 3.3, 6.4, 4.3, and 9.4 nM against TRKA, TRKB, TRKC, and the mutant TRKA G667C, respectively. Additionally, this compound exhibits IC50 values of 1.3 nM against FLT3, 9.9 nM against RET, and 71.1 nM against VEGFR2. TRK II-IN-1 primarily serves as a research tool for studying TRK-driven cancers [1].

    价 格：￥电议型 号：T73033产 地：中国大陆

  • T63805β-Glucuronidase/hCAII-IN-1；化合物 β-Glucuronidase/hCAII-IN-1β-Glucuronidase/hCAII-IN-1

    β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a compound that effectively inhibits both β-glucuronidase and human Carbonic Anhydrase II (hCA II), exhibiting IC50 values of 440.1 μM and 4.91 μM, respectively [1].

    价 格：￥电议型 号：T63805产 地：中国大陆

  • T63752hCAII-IN-1；化合物 hCAII-IN-1hCAII-IN-1

    hCAII-IN-1 (compound 7f) is a selective and potent inhibitor of carbonic anhydrase (CA II/IX) with their Kis values of 1.2 and 113.6 nM, respectively. hCAII-IN-1 has shown investigational potential for cancer disease.

    价 格：￥电议型 号：T63752产 地：中国大陆

  • T63557hCA I-IN-1；化合物 hCA I-IN-1hCA I-IN-1

    hCA I-IN-1 is a human carbonic anhydrase I (hCA I) inhibitor that acts on hCA I (Ki: 38.3 nM), hCA II (Ki: 716.4 nM), hCAIX (Ki: 940.1 nM) and hCAXII (Ki: 192.8 nM).

    价 格：￥电议型 号：T63557产 地：中国大陆

  • T63234Factor XI-IN-1；化合物 Factor XI-IN-1Factor XI-IN-1

    Factor XI-IN-1 is an inhibitor of factor XI activation (EC50: 25.14 nM).

    价 格：￥电议型 号：T63234产 地：中国大陆

  • T62892hCAI/II-IN-1；化合物 hCAI/II-IN-1hCAI/II-IN-1

    hCAI/II-IN-1 (Compound 3h) is a human carbonic anhydrase I and II (hCA I/II) inhibitor that acts on hCA I (IC50: 0.047 μM) and hCA II (IC50: 0.024 μM).

    价 格：￥电议型 号：T62892产 地：中国大陆

  • T62423GCPII-IN-1 TFA；化合物 GCPII-IN-1 TFAGCPII-IN-1 TFA

    GCPII-IN-1 TFA is a glutamate carboxypeptidase II (GCPII; PSMA) inhibitor scaffold (Ki: 44.3 nM).

    价 格：￥电议型 号：T62423产 地：中国大陆

  • T62048Topo I-IN-1；化合物 Topo I-IN-1Topo I-IN-1

    Topo I-IN-1 (Compound 14d) is a potent Topo I inhibitor. Topo I-IN-1 exhibits antitumor activity and DNA intercalative capability. Topo I-IN-1 can induce cell apoptosis.

    价 格：￥电议型 号：T62048产 地：中国大陆

  • T61981Human carbonic anhydrase II-IN-1；化合物 Human carbonic anhydrase II-IN-1Human carbonic anhydrase II-IN-

    Human carbonic anhydrase II-IN-1 (Compound S-13) is a potent human carbonic anhydrase II (hCA II) inhibitor. Human carbonic anhydrase II-IN-1 shows Kis of 4.4 nM, 9.2 nM, 480.2 nM and 14.7 nM for hCA II, I, IV and IX, respectively. Human carbonic anhydrase II-IN-1 can be used for glaucoma research.

    价 格：￥电议型 号：T61981产 地：中国大陆

  • T61873hCAIX/XII-IN-1；化合物 hCAIX/XII-IN-1hCAIX/XII-IN-1

    hCAIX/XII-IN-1, a potent inhibitor of both CAIX and CAXII, exhibits KI values of 0.48 μM for CAIX and 0.83 μM for CAXII, respectively. This compound demonstrates antiproliferative activity in vitro and induces apoptosis in MCF-7 cells [1].

    价 格：￥电议型 号：T61873产 地：中国大陆

  • T61720Pol I-IN-1；化合物 Pol I-IN-1Pol I-IN-1

    Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibition concentration (IC50) of 0.21 μM [1].

    价 格：￥电议型 号：T61720产 地：中国大陆

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