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T16161Mutant IDH1 inhibitor
Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).
价 格：￥电议型 号：T16161产 地：中国大陆
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T12128Mutant IDH1-IN-2
Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of 16.6 nM in Fluorescence biochemical assay, IC50 of ＜22 nM in LS-MS biochemical assay.
价 格：￥电议型 号：T12128产 地：中国大陆
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T16161Mutant IDH1 inhibitorMutant IDH1 inhibitor
Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).
价 格：￥电议型 号：T16161产 地：美洲
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T78758IHMT-IDH1-053；化合物 IHMT-IDH1-053IHMT-IDH1-053
IHMT-IDH1-053 (compound 16) is an irreversible inhibitor exhibiting high selectivity for the IDH1 R132H mutant, achieving an IC50 of 4.7 nM. It preferentially targets IDH1 mutants over wild-type IDH1 and IDH2, both wild-type and mutants. In 293T cells transfected with the IDH1 R132H mutant, IHMT-IDH1-053 reduces 2-hydroxyglutarate (2-HG) production with an IC50 value of 28 nM. The compound engages with the R132H protein at an allosteric site near the NAPDH binding region, forming a covalent link
价 格：￥电议型 号：T78758产 地：中国大陆
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T72705IDH1 Inhibitor 7；化合物 IDH1 Inhibitor 7IDH1 Inhibitor 7
IDH1 Inhibitor 7 is an IDH1 inhibitor with an IC 50 of less than 100 nM [1] .
价 格：￥电议型 号：T72705产 地：中国大陆
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T63403WT IDH1 Inhibitor 2；化合物 WT IDH1 Inhibitor 2WT IDH1 Inhibitor 2
WT IDH1 Inhibitor 2 is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor (IC50: 120 nM) and is a mutant R132H IDH1 inhibitor, an isoform of GSK321 with wild-type cross-reactivity.
价 格：￥电议型 号：T63403产 地：中国大陆
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T63402(S,R)-WT IDH1 Inhibitor 2；化合物 (S,R)-WT IDH1 Inhibitor 2(S,R)-WT IDH1 Inhibitor 2
(S,R)-WT IDH1 Inhibitor 2 is a selective and potent mutant IDH1 inhibitor that inhibits R132G (IC50: 2.9 nM), R132C (IC50: 3.8 nM), R132H (IC50: 4.6 nM) and WT IDH1 (IC50: 46 nM) with 100-fold higher selectivity than IDH2. 100-fold higher selectivity than IDH2. (S,R)-WT IDH1 Inhibitor 2 is investigated in acute myeloid leukemia (AML) and other cancers for its ability to induce intracellular 2-HG reduction, failure of myeloid differentiation block, and induction of granulocyte differentiation at
价 格：￥电议型 号：T63402产 地：中国大陆
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T62725IDH1 Inhibitor 5；化合物 IDH1 Inhibitor 5IDH1 Inhibitor 5
IDH1 Inhibitor 5 (compound 2) is an inhibitor of IDH1 (isocitrate dehydrogenase 1), which inhibits MOG cells (IC50: 64.4 nM) and wild-type IDH1 glioma cells expressing exogenous mutant IDH1 R132H protein (IC50: 34.9 nM).
价 格：￥电议型 号：T62725产 地：中国大陆
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T39716Mutant IDH1-IN-6Mutant IDH1-IN-6Mutant IDH1-IN-6
Mutant IDH1-IN-6 is an orally active compound that effectively inhibits mutant isocitrate dehydrogenase (IDH) enzymes. It demonstrates potency and selectivity, with IC50 values of 6.27, 3.71, 36.9, and 11.5 nM for IDH1 R132H, IDH1 R132C, IDH2 R140Q, and IDH2 R172K mutants, respectively. Notably, Mutant IDH1-IN-6 exhibits lower activity in inhibiting wild-type IDH enzymes.
价 格：￥电议型 号：T39716产 地：中国大陆
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T16161Mutant IDH1 inhibitor；化合物Mutant IDH1 inhibitorMutant IDH1 inhibitor
Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).
价 格：￥电议型 号：T16161产 地：中国大陆
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T12129Mutant IDH1-IN-4；化合物 T12129Mutant IDH1-IN-4
Mutant IDH1-IN-4 is an mutant Isocitrate dehydrogenase 1 (IDH 1) inhibitor.
价 格：￥电议型 号：T12129产 地：中国大陆
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T12128Mutant IDH1-IN-2；化合物Mutant IDH1-IN-2Mutant IDH1-IN-2
Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of 16.6 nM in Fluorescence biochemical assay, IC50 of ＜22 nM in LS-MS biochemical assay.
价 格：￥电议型 号：T12128产 地：中国大陆
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T11613IDH1 Inhibitor 1；化合物 T11613IDH1 Inhibitor 1
IDH1 Inhibitor 1 is an orally bioavailable, brain-penetrant, and selective mutant IDH1 inhibitor (IC50s: 0.021 μM, 0.045 μM, and 2.52 μM for IDH1R132H, IDH1R132C, and IDH1WT).
价 格：￥电议型 号：T11613产 地：中国大陆
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T11612IDH1 Inhibitor 3；化合物 T11612IDH1 Inhibitor 3
IDH1 Inhibitor 3 is a mutant isocitric dehydrogenase 1 (IDH1) inhibitor (IC50: 45 nM for IDH1R132H).
价 格：￥电议型 号：T11612产 地：中国大陆
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T11611IDH1 Inhibitor 2；化合物 T11611IDH1 Inhibitor 2
IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).
价 格：￥电议型 号：T11611产 地：中国大陆
