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  • T9381Thalidomide 5-fluorideIRAK4 protein,E3 ligase-recruiting Moiety,protac,Ligand for E3 Ligase,Thalidom

    Thalidomide 5-fluoride is a chemical compound.

    价 格：￥电议型 号：T9381产 地：中国大陆

  • T5354IRAK4-IN-7CA-4948

    CA-4948 (previously AU-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.

    价 格：￥电议型 号：T5354产 地：中国大陆

  • T4140IRAK4-IN-1

    IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.

    价 格：￥电议型 号：T4140产 地：中国大陆

  • T11673IRAK4-IN-4

    IRAK4-IN-4 inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor, has an IC50 of 2.8 nM.

    价 格：￥电议型 号：T11673产 地：中国大陆

  • T11673IRAK4-IN-4IRAK4-IN-4

    IRAK4-IN-4 inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor, has an IC50 of 2.8 nM.

    价 格：￥电议型 号：T11673产 地：美洲

  • T81378PROTAC IRAK4 ligand-3；化合物 PROTAC IRAK4 ligand-3PROTAC IRAK4 ligand-3

    PROTAC IRAK4 Ligand-3 serves as a ligand for PROTAC IRAK4 Degrader-7 and is utilized in cancer research [1].

    价 格：￥电议型 号：T81378产 地：中国大陆

  • T79485IRAK4-IN-27；化合物 IRAK4-IN-27IRAK4-IN-27

    IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM. It effectively suppresses cell growth and induces apoptosis in the MYD88 L265P diffuse large B-cell lymphoma (DLBCL) cell line, positioning it as a valuable agent for DLBCL research [1].

    价 格：￥电议型 号：T79485产 地：中国大陆

  • T79448IRAK4-IN-26；化合物 IRAK4-IN-26IRAK4-IN-26

    IRAK4-IN-26 (Compound 21), an IRAK4 inhibitor with an IC50 of 6.2 nM, exhibits an oral bioavailability of 21%. It is utilized for the study of inflammatory and autoimmune disorders [1].

    价 格：￥电议型 号：T79448产 地：中国大陆

  • T79447IRAK4-IN-25；化合物 IRAK4-IN-25IRAK4-IN-25

    IRAK4-IN-25 (compound 38), a potent oral IRAK4 inhibitor (IC50 = 7.3 nM) with low clearance (Cl = 12 mL/min/kg), effectively suppresses pro-inflammatory cytokine production and demonstrates favorable in vitro safety and ADME profiles. It is suitable for research on inflammatory and autoimmune disorders [1].

    价 格：￥电议型 号：T79447产 地：中国大陆

  • T79337IRAK4-IN-28；化合物 IRAK4-IN-28IRAK4-IN-28

    IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a Kd of 0.58 nM for the target enzyme. It is utilized for research purposes in the study of inflammation and autoimmune diseases [1].

    价 格：￥电议型 号：T79337产 地：中国大陆

  • T79097PROTAC IRAK4 degrader-8；化合物 PROTAC IRAK4 degrader-8PROTAC IRAK4 degrader-8

    PROTAC IRAK4 Degrader-8 (Compound 2) is a PROTAC designed to target IRAK4 with an IC50 of 15.5 nM [1].

    价 格：￥电议型 号：T79097产 地：中国大陆

  • T78744IRAK4-IN-24；化合物 IRAK4-IN-24IRAK4-IN-24

    IRAK4-IN-24 (compound 16), a potent IRAK4 inhibitor, exhibits high clearance (Cl) and low oral bioavailability. It is utilized in research pertaining to inflammatory and autoimmune disorders.

    价 格：￥电议型 号：T78744产 地：中国大陆

  • T74062PROTAC IRAK4 degrader-2；化合物 PROTAC IRAK4 degrader-2PROTAC IRAK4 degrader-2

    PROTAC IRAK4 Degrader-2 (Compound 9) is a PROTAC-based degrader that potently reduces IRAK4 levels, achieving a DC50 of 151 nM in peripheral blood mononuclear cells (PBMCs). It also notably decreases IRAK4 protein levels with a DC50 of 36 nM in the same cell type and inhibits several cytokines in PBMCs [1].

    价 格：￥电议型 号：T74062产 地：中国大陆

  • T63559IRAK4-IN-22；化合物 IRAK4-IN-22IRAK4-IN-22

    IRAK4-IN-22 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 3 nM) and TAK1 (IC50: 17 nM). IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.10 μM. IRAK4-IN-21 can be used to study autoimmune diseases, such as plaque psoriasis and psoriatic arthritis.

    价 格：￥电议型 号：T63559产 地：中国大陆

  • T63558IRAK4-IN-21；化合物 IRAK4-IN-21IRAK4-IN-21

    IRAK4-IN-21 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 5 nM) and TAK1 (IC50: 56 nM). IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.17 μM. can be used to study autoimmune diseases, such as plaque psoriasis and psoriatic arthritis.

    价 格：￥电议型 号：T63558产 地：中国大陆

  • T63388IRAK4-IN-8；IRAK4 抑制剂8IRAK4-IN-8

    IRAK4-IN-8 (VI-177) is an IRAK4 inhibitor for the study of diseases associated with cancer and inflammation.

    价 格：￥电议型 号：T63388产 地：中国大陆

  • T63315IRAK4-IN-19；化合物 IRAK4-IN-19IRAK4-IN-19

    IRAK4-IN-19 is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK4) (IC50: 4.3 nM).IRAK4-IN-19 inhibits LPS-induced IL23 production in THP and DC cells and suppresses the development of arthritis in arthritis model rats.IRAK4-IN-19 can be used to study arthritic diseases.

    价 格：￥电议型 号：T63315产 地：中国大陆

  • T63278IRAK4-IN-14；化合物 IRAK4-IN-14IRAK4-IN-14

    IRAK4-IN-14 is a selective, potent, orally active IRAK4 inhibitor (IC50: 0.003 μM) with favorable PK parameters in rats and mice. effect.

    价 格：￥电议型 号：T63278产 地：中国大陆

  • T63262IRAK4-IN-15；化合物 IRAK4-IN-15IRAK4-IN-15

    IRAK4-IN-15 is a selective and potent IRAK4 inhibitor (IC50: 0.002 μM) with good human PK prediction and low intrinsic clearance.IRAK4-IN-15 in combination with Acalabrutinib exhibited potent synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL.

    价 格：￥电议型 号：T63262产 地：中国大陆

  • T62989IRAK4-IN-12；化合物 IRAK4-IN-12IRAK4-IN-12

    IRAK4-IN-12 (compound 37) is a potent inhibitor of IRAK4 (IC50: 0.015 μM) with cellular pIRAK4 potency (IC50: 0.5 μM).

    价 格：￥电议型 号：T62989产 地：中国大陆

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