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  • T8742G5-7antiangiogenic,inhibit,Apoptosis,JAK,Glioma,G-5-7,cycle,G5 7,phase,G57,STAT3,cell,Inhibitor,EGFR

    JAK2 inhibitor G5-7 is an orally active JAK2 inhibitor, selectively inhibits JAK2–mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 has the potential for glioma study

    价 格：￥电议型 号：T8742产 地：中国大陆

  • T9251Fedratinib hydrochloride hydrateSTAT5,JAK2V617F,myeloproliferative,TG-101348 hydrochloride,Janus kin

    Fedratinib hydrochloride hydrate is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.

    价 格：￥电议型 号：T9251产 地：中国大陆

  • T35900JAK2-IN-7JAK2-IN-7

    JAK2-IN-7 is a selective JAK2 inhibitor with IC50s of 3, 11.7, and 41 nM for JAK2, SET-2, and Ba/F3V617F cells, respectively. JAK2-IN-7 possesses >14-fold selectivity over JAK1, JAK3, FLT3. JAK2-IN-7 stimulates cell cycle arrest in the G0/G1 phase and ind

    价 格：￥电议型 号：T35900产 地：中国大陆

  • T3042NSC 42834Z3；JAK2 Inhibitor V；JAK2 Inhibitor V Z3

    NSC 42834(JAK2 Inhibitor V, Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.

    价 格：￥电议型 号：T3042产 地：中国大陆

  • T19017JAK2 JH2 TracerJAK2 JH2 Tracer

    JAK2 JH2 Tracer is a fluorescent probe for the JAK2 JH2 domain (Kd: 0.2 μM).

    价 格：￥电议型 号：T19017产 地：美洲

  • T8742G5-7；化合物JAK2 inhibitor G5-7JAK2 inhibitor G5-7；JAK2 inhibitor G5-7

    JAK2 inhibitor G5-7 (JAK2 inhibitor G5-7) is an orally active JAK2 inhibitor, selectively inhibits JAK2–mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 has the potential for glioma study

    价 格：￥电议型 号：T8742产 地：中国大陆

  • T80921Tubulin/JAK2-IN-1；化合物 Tubulin/JAK2-IN-1Tubulin/JAK2-IN-1

    Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significant antiproliferative effects against cancer cells [1].

    价 格：￥电议型 号：T80921产 地：中国大陆

  • T79581JAK2-IN-9；化合物 JAK2-IN-9JAK2-IN-9

    Compound A8, known as JAK2-IN-9, is a selective JAK2 inhibitor with an IC50 of 5 nM. It effectively inhibits the phosphorylation of JAK2, STAT3, and STAT5, possesses metabolic stabilities, and induces apoptosis. This compound is utilized in the study of myeloproliferative neoplasms (MPNs) [1].

    价 格：￥电议型 号：T79581产 地：中国大陆

  • T72754JAK2/STAT3-IN-1；化合物 JAK2/STAT3-IN-1JAK2/STAT3-IN-1

    JAK2/STAT3-IN-1 -10a) is a potent inhibitor of GP130, exhibiting an IC50 value of 3.04 ?M and demonstrating anti-tumor activity.

    价 格：￥电议型 号：T72754产 地：中国大陆

  • T71193Jak2-IN-7j；化合物 Jak2-IN-7jJak2-IN-7j

    Jak2-IN-7j is a selective Jak2 inhibitor which demonstrates a time-dependent knock-down of pSTAT5, which is a downstream target of Jak2.

    价 格：￥电议型 号：T71193产 地：中国大陆

  • T64227JAK2 JH2 binder-1；化合物 JAK2 JH2 binder-1JAK2 JH2 binder-1

    JAK2 JH2 binder-1 is a potent and selective JAK2 JH2 binder (Ki: 37.1 nM). JAK2 JH2 binder-1 has the potential to be used in the study of various myeloproliferative neoplasms.

    价 格：￥电议型 号：T64227产 地：中国大陆

  • T64104JAK2/FLT3-IN-1 TFA；化合物 JAK2/FLT3-IN-1 TFAJAK2/FLT3-IN-1 TFA

    JAK2/FLT3-IN-1 (TFA) is an orally active dual inhibitor of JAK2/FLT3 that exhibits anticancer effects, acting on JAK2 (IC50: 0.7 nM), FLT3 (IC50: 4 nM), JAK1 (IC50: 26 nM) and JAK3 (IC50: 39 nM).

    价 格：￥电议型 号：T64104产 地：中国大陆

  • T63146JAK2/TYK2-IN-1；化合物 JAK2/TYK2-IN-1JAK2/TYK2-IN-1

    JAK2/TYK2-IN-2 is a potent and selective inhibitor of TYK2 (IC50: 9 nM) and JAK2 (IC50: 157 nM) with anti-inflammatory effects.

    价 格：￥电议型 号：T63146产 地：中国大陆

  • T62317α7 nAchR-JAK2-STAT3 agonist 1；化合物 α7 nAchR-JAK2-STAT3 agonist 1α7 nAchR-JAK2-STAT3 agonist 1

    α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM). α7 nAchR-JAK2-STAT3 agonist 1 has been shown to have a positive effect on iNOS, IL-1β and IL-1β in murine macrophages RAW264.7. α7 nAchR-JAK2-STAT3 agonist 1 was effective in inhibiting the expression of iNOS, IL-1β and IL-6 in mouse macrophages. α7 nAchR-JAK2-STAT3 agonist 1 inhibited LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK

    价 格：￥电议型 号：T62317产 地：中国大陆

  • T40443JAK2-IN-6；化合物JAK2-IN-6JAK2-IN-6；JAK2-IN-6

    JAK2-IN-6, a polysubstituted aminothiazole derivative, is a potent and selective inhibitor of JAK2 (ic50 at 22.86 μg/mL). Jak2-in-6 inhibits the activity of JAK2 enzymes by interfering with Jak2-related signaling pathways, thereby producing therapeutic effects on the specific disease IN which JAK2 is dysregulated, and does not show activity on JAK1 and JAK3. JAK2 is a protein involved in signaling pathways that regulate cell growth and division. Abnormal activation of JAK2 has been linked to a v

    价 格：￥电议型 号：T40443产 地：中国大陆

  • T35900JAK2-IN-7；化合物JAK2-IN-7JAK2-IN-7；JAK2-IN-7

    JAK2-IN-7, a selective inhibitor targeting Janus Kinase 2 (JAK2), exhibits inhibitory concentrations (IC50) of 3 nM for JAK2, 11.7 nM for SET-2 cells, and 41 nM for Ba/F3 V617F cells, indicative of its potency and selectivity. This compound demonstrates more than 14-fold selectivity against JAK1, JAK3, and FLT3, underlining its specificity. JAK2-IN-7 effectively induces cell cycle arrest at the G0/G1 phase and promotes apoptosis in tumor cells, manifesting significant antitumor activities [1].

    价 格：￥电议型 号：T35900产 地：中国大陆

  • T3042JAK2 Inhibitor V；化合物 JAK2 Inhibitor VJAK2 Inhibitor V Z3|||Z3；JAK2 Inhibitor V Z3|||Z3

    JAK2 Inhibitor V (JAK2 Inhibitor V Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.

    价 格：￥电议型 号：T3042产 地：中国大陆

  • T19017JAK2 JH2 Tracer；化合物 T19017JAK2 JH2 Tracer

    JAK2 JH2 Tracer is a fluorescent probe for the JAK2 JH2 domain (Kd: 0.2 μM).

    价 格：￥电议型 号：T19017产 地：中国大陆

  • T11708JAK2-IN-4；化合物 T11708JAK2-IN-4

    JAK2-IN-4 is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.

    价 格：￥电议型 号：T11708产 地：中国大陆

  • T11707JAK2/FLT3-IN-1；化合物 T11707JAK2/FLT3-IN-1

    JAK2/FLT3-IN-1 has anti-cancer activity. JAK2/FLT3-IN-1 is a potent and orally effective dual JAK2/FLT3 (Janus kinase 2/ FMS-like tyrosine kinase 3) inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively.

    价 格：￥电议型 号：T11707产 地：中国大陆

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