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T74818JNK3 inhibitor-8；化合物 JNK3 inhibitor-8JNK3 inhibitor-8
JNK3 Inhibitor-8 is a potent, selective, and orally active inhibitor that can cross the blood-brain barrier, targeting JNK3 with IC50 values of 21 nM for JNK3, 2203 nM for JNK2, and >10000 nM for JNK1. This compound demonstrates significant neuroprotective effects and holds promise for Alzheimer’s disease (AD) research [1].
价 格：￥电议型 号：T74818产 地：中国大陆
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T74817JNK3 inhibitor-7；化合物 JNK3 inhibitor-7JNK3 inhibitor-7
JNK3 inhibitor-7, a potent and orally active compound that can cross the blood-brain barrier, acts as a JNK3 inhibitor with IC50 values of 53 nM for JNK3, 973 nM for JNK2, and 1039 nM for JNK1. Demonstrating significant neuroprotective effects, JNK3 inhibitor-7 holds potential for Alzheimer’s disease (AD) research [1].
价 格：￥电议型 号：T74817产 地：中国大陆
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T72715JNK3 inhibitor-4；化合物 JNK3 inhibitor-4JNK3 inhibitor-4
JNK3 Inhibitor-4, a potent 2-aryl-1-pyrimidinyl-1H-imidazole-5-yl acetonitrile derivative, demonstrates a strong inhibitory effect on JNK3 with an IC 50 value of 1.0 nM. It exhibits exceptional selectivity against JNK3 when compared to other protein kinases, including isoforms JNK1 (IC 50 = 143.9 nM) and JNK2 (IC 50 = 298.2 nM). Additionally, JNK3 Inhibitor-4 benefits from neuroprotective properties and is predicted to permeate the blood-brain barrier effectively.
价 格：￥电议型 号：T72715产 地：中国大陆
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T72714JNK3 inhibitor-3；化合物 JNK3 inhibitor-3JNK3 inhibitor-3
JNK3 Inhibitor-3 (compound 15g) is a selective, blood-brain barrier permeable, and orally active inhibitor of c-Jun N-terminal kinase 3 (JNK3) with IC50 values of 147.8 nM, 44.0 nM, and 4.1 nM against JNK1, JNK2, and JNK3, respectively. This compound has been shown to significantly enhance memory in mouse models of dementia and is utilized in Alzheimer’s disease research [1].
价 格：￥电议型 号：T72714产 地：中国大陆
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T60805JNK3 inhibitor-2；化合物 JNK3 inhibitor-2JNK3 inhibitor-2
JNK3 inhibitor-2 is a potent and selective JNK3 inhibitor. The IC50 values of JNK3 inhibitor-2 for JNK1, JNK2, JNK3 are >100, >100, 0.25 μM, respectively. JNK3 inhibitor-2 also inhibits DDR1 and EGFR (T790M, L858R) [1].
价 格：￥电议型 号：T60805产 地：中国大陆
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T40248JNK3 inhibitor-1JNK3 inhibitor-1JNK3 inhibitor-1
JNK3 inhibitor-1 is a highly potent and selective compound that specifically inhibits JNK3 with an impressive IC50 value of 0.005 μM. In addition to its remarkable inhibitory effects, JNK3 inhibitor-1 possesses excellent oral bioavailability and the ability to efficiently penetrate the brain.
价 格：￥电议型 号：T40248产 地：中国大陆
