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T11576HSL-IN-1HSL-IN-1
HSL-IN-1, a significantly reduced reactive metabolite liability.?is a potent and orally active hormone sensitive lipase (HSL) inhibitor (IC50=2 nM).
价 格:¥电议型 号:T11576产 地:美洲
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T81881MAGL-IN-10;化合物 MAGL-IN-10MAGL-IN-10
MAGL-IN-10, a reversible monoacylglycerol lipase (MAGL) inhibitor, exhibits favorable ADME properties and low in vivo toxicity. It is applicable in the study of cancer, neurological disorders, and inflammatory pathologies [1].
价 格:¥电议型 号:T81881产 地:中国大陆
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T81880MAGL-IN-11;化合物 MAGL-IN-11MAGL-IN-11
MAGL-IN-11 (compound 29) is a selective, reversible inhibitor of monoacylglycerol lipase (MAGL), with potential in researching inflammation, cancer, and antioxidants [1].
价 格:¥电议型 号:T81880产 地:中国大陆
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T81851MASTL-IN-1;化合物 MASTL-IN-1MASTL-IN-1
MASTL-IN-1 is a potent inhibitor of microtubule-associated serine/threonine kinase-like (MASTL), which plays a role in cell proliferation, migration, and invasion, thereby holding promise in cancer research [1].
价 格:¥电议型 号:T81851产 地:中国大陆
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T79969Axl-IN-16;化合物 Axl-IN-16Axl-IN-16
Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptor tyrosine kinase expression [1].
价 格:¥电议型 号:T79969产 地:中国大陆
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T79720VHL-IN-1;化合物 VHL-IN-1VHL-IN-1
VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and enhances its transcriptional activity. It shows promise for applications as a HIF-1α stabilizer and for the degradation of proteolytically targeted chimeras (PROTACs) [1].
价 格:¥电议型 号:T79720产 地:中国大陆
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T79488RNase L-IN-1;化合物 RNase L-IN-1RNase L-IN-1
RNase L-IN-1 (compound 17a) functions as an inhibitor of RNase L (Ribonuclease L), an enzyme responsible for RNA degradation to inhibit viral replication, and plays a crucial role in mediating innate immune responses and inflammation [1].
价 格:¥电议型 号:T79488产 地:中国大陆
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T79317MBL-IN-1;化合物 MBL-IN-1MBL-IN-1
MBL-IN-1 (compound 41), a β-Lactamase inhibitor, exhibits an IC50 range of 0.10 to 25.85 ?M and is utilized in the study of bacterial infections [1].
价 格:¥电议型 号:T79317产 地:中国大陆
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T79045AXL-IN-15;化合物 AXL-IN-15AXL-IN-15
AXL-IN-15 (cpd391) is a potent inhibitor of Axl, exhibiting both a dissociation constant (K i) and a half-maximal inhibitory concentration (IC50) of less than 1 nanomolar (nM). It is applicable for cancer research [1].
价 格:¥电议型 号:T79045产 地:中国大陆
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T77668hPL-IN-1;人胰脂肪酶抑制剂1hPL-IN-1
hPL-IN-1 is a potent reversible pancreatic lipase (PL) inhibitor (IC50=1.86 μM) that can be used to study obesity-related diseases.
价 格:¥电议型 号:T77668产 地:中国大陆
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T73637Dot1L-IN-1 TFA;化合物 Dot1L-IN-1 TFADot1L-IN-1 TFA
Dot1L-IN-1 TFA is a potent and selective Dot1L inhibitor, characterized by a K i of 2 pM and an IC 50 of <0.1 nM. It effectively inhibits H3K79 dimethylation (IC 50 =3 nM) and suppresses the HoxA9 promoter activity (IC 50 =17 nM) in HeLa and Molm-13 cells, respectively [1].
价 格:¥电议型 号:T73637产 地:中国大陆
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T73324PARL-IN-1;化合物 PARL-IN-1PARL-IN-1
PARL-IN-1, a potent PARL inhibitor, exhibits an IC50 value of 28 nM. It effectively inhibits PARL, consequently robustly activating the PINK1/Parkin pathway and promoting PINK1/Parkin-dependent mitophagy.
价 格:¥电议型 号:T73324产 地:中国大陆
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T73310AXL-IN-14;化合物 AXL-IN-14AXL-IN-14
AXL-IN-14 is a potent, orally active inhibitor of AXL with an IC50 of 0.8 nM that effectively suppresses Gas6/AXL-mediated cell migration and invasion, reduces the expression of p-AXL and p-AKT proteins, and demonstrates anti-tumor activity [1].
价 格:¥电议型 号:T73310产 地:中国大陆
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T73300AXL-IN-13;化合物AXL-IN-13AXL-IN-13
AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) and inhibits cancer cell migration and invasion.
价 格:¥电议型 号:T73300产 地:中国大陆
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T63888Axl-IN-12;化合物 Axl-IN-12Axl-IN-12
Axl-IN-12 is a potent inhibitor of AXL. Axl-IN-12 can be used to study proliferative, allergic, autoimmune, inflammatory, cancer, transplant rejection, viral infectious diseases or other mammalian diseases.
价 格:¥电议型 号:T63888产 地:中国大陆
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T63683Axl-IN-11;化合物 Axl-IN-11Axl-IN-11
Axl-IN-11 is a potent inhibitor of AXL. Axl-IN-11 can be used to study proliferative diseases, allergic diseases, autoimmune diseases, inflammatory diseases, cancer, transplant rejection, viral infectious diseases or other mammalian diseases.
价 格:¥电议型 号:T63683产 地:中国大陆
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T63154Axl-IN-10;化合物 Axl-IN-10Axl-IN-10
Axl-IN-10 is a potent inhibitor of AXL (IC50: 5 nM).Axl-IN-10 has good pharmacokinetic properties in animals and excellent transmembrane properties.Axl-IN-10 can be used to study proliferative, allergic, autoimmune, inflammatory, transplant rejection, cancer or other mammalian diseases.
价 格:¥电议型 号:T63154产 地:中国大陆
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T61605SK3 Channel-IN-1;化合物 SK3 Channel-IN-1SK3 Channel-IN-1
SK3 Channel-IN-1 (compound 7a) is a powerful and selective modulator of the SK3 channel. It demonstrates significant efficacy in inhibiting breast cancer MDA-MB-435 cell migration while maintaining low cytotoxicity in other cell lines. Furthermore, SK3 Channel-IN-1 exhibits the ability to modulate ion channel activity in cancer cells [1].
价 格:¥电议型 号:T61605产 地:中国大陆
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T61198FAAH/MAGL-IN-1;化合物 FAAH/MAGL-IN-1FAAH/MAGL-IN-1
FAAH/MAGL-IN-1, also known as compound SIH 3, is a highly effective inhibitor of FAAH (fatty acid amide hydrolase) and MAGL (monoacylglycerol lipase). It exhibits IC50 values of 31 nM and 29 nM against FAAH and MAGL, respectively. This compound shows promising potential for advancing research in the field of neuropathic pain [1].
价 格:¥电议型 号:T61198产 地:中国大陆
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T60885MLKL-IN-1;化合物 MLKL-IN-1MLKL-IN-1
MLKL-IN-1 is a covalent inhibitor of MLKL with a Kd value of 50 μM.
价 格:¥电议型 号:T60885产 地:中国大陆