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T6736ZafirlukastLeukotriene Receptor,Zafirlukast,ICI-204219,Inhibitor,inhibit,ICI204219
Zafirlukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma.
价 格：￥电议型 号：T6736产 地：中国大陆
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T6893MK-886leukotriene,FLAP,5-LOX,5-LO activating protein,non-competitive,L-663536,L663536,keratin-1,Leuk
MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
价 格：￥电议型 号：T6893产 地：中国大陆
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T3148MK-571 sodiumMRP4,Lysophospholipid Receptor,human mast cells,LAD2,MK 571 sodium,MRP1,Leukotriene Rec
MK-571 is a selective, orally active antagonist of the CysLT1 receptor. MK571 is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the cellular efflux of drugs, xenobiotics, and their conjugates. MK571 can inhibit the synthesis of K-4′-O-GlcA (19.7 μM). MK571 dose-dependently inhibits the intracellular biosynthesis of all flavonol sulphates and glucuronides by Caco-2 cells. MK571 significantly inhibits phase-2 conjugation of kaempferol by cell-free
价 格：￥电议型 号：T3148产 地：中国大陆
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T7786TryptanthrinLeukotriene biosynthesis,Nitric oxide synthases,indole quinazoline,Inhibitor,Tumor Necro
Tryptanthrin is a natural DNA gyrase inhibitor.
价 格：￥电议型 号：T7786产 地：中国大陆
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T7379320-Carboxy-Leukotriene B4；化合物 20-Carboxy-Leukotriene B420-Carboxy-Leukotriene B4
20-Carboxy-Leukotriene B4 (20-COOH LTB4), a metabolite of Leukotriene B4 (LTB4), exhibits high affinity binding to the BLT1 receptor. It notably inhibits LTB4-mediated neutrophil responses, including migration, degranulation, and leukotriene biosynthesis [1].
价 格：￥电议型 号：T73793产 地：中国大陆
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T721446-trans-12-epi-Leukotriene B4；化合物 6-trans-12-epi-Leukotriene B46-trans-12-epi-Leukotriene B4
6-trans-12-epi-Leukotriene B4, a metabolite of arachidonic acid, serves as a potent anti-inflammatory agent.
价 格：￥电议型 号：T72144产 地：中国大陆
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T40870Leukotriene E4；白三烯 E4LTE4；LTE4
Leukotriene E4 (LTE4) (LTE4) is produced by the action of dipeptidyl peptidase on LTD4 and is a component of the Slow Reactive Substance of Anaphylaxis (SRS-A).LTE4 is present in plasma and urine and can be used to detect asthma.
价 格：￥电议型 号：T40870产 地：中国大陆
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T38129Leukotriene F4；Leukotriene F4LTF4；LTF4
LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contract vascular smooth muscle. [1] The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD4 > LTC4 > LTE4 >> LTF4. [1] [2]
价 格：￥电议型 号：T38129产 地：中国大陆
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T38128Leukotriene D4；Leukotriene D4 MaxSpec? StandardLeukotriene D4 MaxSpec? Standard|||LTD4；Leukotriene D
Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. It is the first cysteinyl-leukotriene metabolite of LTC4 . Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity. LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of
价 格：￥电议型 号：T38128产 地：中国大陆
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T3808720-hydroxy Leukotriene B4；20-hydroxy Leukotriene B420-hydroxy Leukotriene B4；20-hydroxy Leukotriene
20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2
价 格：￥电议型 号：T38087产 地：中国大陆
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T38062N-acetyl Leukotriene E4；N-acetyl Leukotriene E4N-acetyl Leukotriene E4；N-acetyl Leukotriene E4
N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile. This route of metabolism is prominent in the rat, but of minor importance in humans. N-acetyl LTE4 is 100 times less potent than LTC4 as a vasoconstricting agent. In healthy human subjects urinary excretion of N-acetyl LTE4 is about 1.5 nmol/mol creatinine, which is considerably less than that of LTE4 (12 nmol/mol creatinine).
价 格：￥电议型 号：T38062产 地：中国大陆
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T37980N-methyl Leukotriene C4；N-methyl Leukotriene C4N-methyl Leukotriene C4；N-methyl Leukotriene C4
Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukot
价 格：￥电议型 号：T37980产 地：中国大陆
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T3797012-epi Leukotriene B4；12-epi Leukotriene B412-epi Leukotriene B4；12-epi Leukotriene B4
Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic pr
价 格：￥电议型 号：T37970产 地：中国大陆
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T37620Leukotriene C4 methyl ester；Leukotriene C4 methyl esterLeukotriene C4 methyl ester
Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute all
价 格：￥电议型 号：T37620产 地：中国大陆
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T37619Leukotriene B4 Ethanolamide；Leukotriene B4 EthanolamideLeukotriene B4 Ethanolamide
The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2. LTB4 is a high affinity ligand for BLT1, and many of its pro-inflammatory effects are believed to be transduced through this receptor. The BLT2 is more enigmatic, in that LTB4 is not a high-affinity ligand, nor is it clear that BLT2 activation promotes inflammation. LTB4 ethanolamide (LTB4-EA) is a theoretical 5-LO metabolite of arachidonoyl ethanolamide (AEA). In CHO cells transfected with human BLTR1, LTB4
价 格：￥电议型 号：T37619产 地：中国大陆
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T37618Leukotriene B4 dimethyl amide；Leukotriene B4 dimethyl amideLeukotriene B4 dimethyl amide；Leukotriene
LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL. LTB4 dimethyl amide appears to be an antagonist of the LTB4 receptor on guinea pig lung membranes.
价 格：￥电议型 号：T37618产 地：中国大陆
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T37617Leukotriene B3；Leukotriene B3Leukotriene B3
LTB3 is the LTA hydrolase metabolite of LTA3 in the leukotriene biosynthetic pathway. LTB3 and LTB4 are equipotent in their pro-inflammatory effects. However, LTB3 is five times less potent than LTB4 in eliciting chemotaxis of human neutrophils.
价 格：￥电议型 号：T37617产 地：中国大陆
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T37616Leukotriene A4 methyl ester；Leukotriene A4 methyl esterLeukotriene A4 methyl ester；Leukotriene A4 me
Leukotriene A4 methyl ester can be converted into leukotriene C4 monomethyl ester catalyzed by the major alkaline cytosolic glutathione transferase in rat liver, which can be used in metabolism-related studies.
价 格：￥电议型 号：T37616产 地：中国大陆
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T37615Leukotriene A3 methyl ester；Leukotriene A3 methyl esterLeukotriene A3 methyl ester
Biosynthesis of LTA3 occurs from 5,8,11-eicosatrienoic acid via the 5-LO pathway and it is the putative intermediate in the biosynthesis of 3-series leukotrienes. LTA3 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.
价 格：￥电议型 号：T37615产 地：中国大陆
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T3749411-trans Leukotriene E4；11-trans Leukotriene E411-trans Leukotriene E4；11-trans Leukotriene E4
Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.
价 格：￥电议型 号：T37494产 地：中国大陆
