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T9177BPAM344Ionotropic glutamate receptors,GluK3a,PAM,iGluR,BPAM344,BPAM 344,Inhibitor,BPAM-344,KAR,GluK1
BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.
价 格:¥电议型 号:T9177产 地:中国大陆
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T60085MM3122
MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor, IC50 = 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.
价 格:¥电议型 号:T60085产 地:中国大陆
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T9019JHU37152JHU37152,inhibit,hM3Dq,Clozapine,Inhibitor,DREADD,Muscarinic acetylcholine receptor,mAChR,hM
JHU 37152 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
价 格:¥电议型 号:T9019产 地:中国大陆
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T7412Tandospirone citrateSM3997,SM-3997,Tandospirone,Tandospirone citrate,Inhibitor,Serotonin Receptor,SM
Tandospirone citrate is a potent and selective 5-HT1A receptor partial agonist (Ki : 27 nM)
价 格:¥电议型 号:T7412产 地:中国大陆
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T9758dCeMM3?degradation,dCeMM 3,dCeMM3?,Inhibitor,inhibit,CDK,CDK12,Cyclin dependent kinase,glue degrader
dCeMM3 is a glue degrader. dCeMM3 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, result in inducing ubiquitination and degradation of cyclin K.
价 格:¥电议型 号:T9758产 地:中国大陆
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T0794Mepenzolate BromideHCAR2,PUMA-G,inhibit,Muscarinic acetylcholine receptor,Inhibitor,hM3R,gastrointes
Mepenzolate Bromide is a muscarinic antagonist used to treat gastrointestinal conditions.
价 格:¥电议型 号:T0794产 地:中国大陆
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T8921M-31850inhibit,M31850,OfHex2,M-31850,β-hexosaminidase,non-carbohydrate,Inhibitor,M 31850
M-31850 is a potent, selective and competitive β-hexosaminidase (Hex) inhibitor(human HexA and human HexB with IC50s of 6.0 μM and 3.1 μM, respectively). IT also competitively inhibits β-N-acetyl-D-hexosaminidase OfHex2 with a Ki of 2.5 μM.
价 格:¥电议型 号:T8921产 地:中国大陆
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T8531m-3M3FBScalcium,superoxide,cells,THP-1,phosphate,m 3M3FBS,m-3M3FBS,Apoptosis,Inhibitor,m3M3FBS,Phosp
m-3M3FBS is a phospholipase C (PLC) activator.
价 格:¥电议型 号:T8531产 地:中国大陆
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T9102WM-3835invasion,MYST2,HBO1,WM3835,MYLK-HOXA9,Histone Acetyltransferase,Apoptosis,inhibit,H4K12ac,HAT
WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.
价 格:¥电议型 号:T9102产 地:中国大陆
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T9468FR054FR054,FR 054,TNBC,HBP,inhibit,Negative,Cancer,Inhibitor,Breast,Triple,PGM3,FR-054
FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and survival.
价 格:¥电议型 号:T9468产 地:中国大陆
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T9018JHU37160Inhibitor,hM4Di,Clozapine,hM3Dq,DREADD,inhibit,Muscarinic acetylcholine receptor,JHU-37160,J
JHU 37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
价 格:¥电议型 号:T9018产 地:中国大陆
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TP1067Pam3CSK4 TFA (112208-00-1 free base)Pam3CSK4 TFA (112208001 free base),Pam3CSK4,Toll-like Receptor (
Pam3CSK4 TFA is an agonist of toll-like receptor 1/2 (TLR1/2) (EC50 of 0.47 ng/mL for human TLR1/2).
价 格:¥电议型 号:TP1067产 地:中国大陆
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T8860DSRM-3716DSRM3716,SARM1,DSRM-3716,NADase,neurodegenerative,cADPR,Inhibitor,5-Iodoisoquinoline,DSRM 3
Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.
价 格:¥电议型 号:T8860产 地:中国大陆
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TP1704Galanin Receptor Ligand M35 TFAGalanin Receptor Ligand M35 TFA,Galanin Receptor Ligand M-35 TFA
Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM).
价 格:¥电议型 号:TP1704产 地:中国大陆
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T9173HM-30181 mesylate monohydrateHM30181 mesylate monohydrate,HM 30181 mesylate monohydrate
HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.
价 格:¥电议型 号:T9173产 地:中国大陆
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T38034MAO-IN-M30 dihydrochloride
MAO-IN-M30 dihydrochloride is a potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson´s disease model.
价 格:¥电议型 号:T38034产 地:中国大陆
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T7359CAY10471 RacemateCAY 10471,CAY10471,TM30089,Inhibitor,CAY-10471,TM 30089,TM-30089,CAY10471 Racemate,
CAY 10471 is a potent, highly selective CRTH2/DP 2 receptor antagonist. CAY10471 binds to the human CRTH2/DP2, DP1, and TP receptors( Ki values of 0.6, 1200, and >10,000 nM,respectively)
价 格:¥电议型 号:T7359产 地:中国大陆
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T8511TM38837peripheral,Cannabinoid Receptor,TM-38837,CB1,antiobesity,TM38837,inhibit,fat,TM 38837,Inhibit
TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes.
价 格:¥电议型 号:T8511产 地:中国大陆
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T6186TRAM-34TRAM 34;Triarylmethane-34;TRAM34
TRAM-34(Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450. The selective activity of TRAM-34 is 200 to 1500-fold than other ion channels.
价 格:¥电议型 号:T6186产 地:中国大陆
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T6145ZM39923 hydrochlorideZM 39923 HCl;JAK3 Inhibitor IV
ZM 39923 HCl is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.
价 格:¥电议型 号:T6145产 地:中国大陆