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T9428HM43239HM43239,HM-43239
HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. HM43239 directly inhibits the kinase activity of FLT3 as a reversible Type I inhibitor and effectively modulates downstream p-STAT5 and p-ERK. HM43239 also demonstrated inhibition of SYK, JAK1/2 and TAK1. HM43239 inhibits the proliferation and induces the apoptosis of leukemic cells [1] [2] [3].
价 格：￥电议型 号：T9428产 地：中国大陆
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T60028MM41inhibit,G-quadruplex,MM41,MM 41,PaCa-2,pancreatic cancer,A549,Inhibitor,cancer,stabilizer,RCC4,7
MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line.
价 格：￥电议型 号：T60028产 地：中国大陆
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T7777M4284Bacterial,M-4284,M4284,inhibit,Inhibitor,UPEC,UTI,mannoside,E.Coil
M 4284 is a selective and orally active biphenyl mannoside FimH antagonist.
价 格：￥电议型 号：T7777产 地：中国大陆
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TP1992LM40 acetate(143896-17-7 free base)M-40 acetate(143896-17-7 free base),M40 acetate(143896 17 7 free b
M40 acetate is a potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.
价 格：￥电议型 号：TP1992L产 地：中国大陆
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T9689M4205factor,M-4205,receptor,M4205,cell,CD117,growth,inhibit,mast/stem,mutations,SCFR,c-Kit,M 4205,In
M4205 is an inhibitor of c-Kit exhibiting high activity on c-Kit mutations in exons 11, 13, 17.
价 格：￥电议型 号：T9689产 地：中国大陆
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T8741MitoBloCK-10Mitochondrial,Protein,Tim44,MitoBloCK10,MitoBloCK 10,MitoBloCK-10,inhibit,Inhibitor,Impo
MitoBloCK-10 inhibits Tim44 binding to the precursor and to Hsp70.MitoBloCK-10 is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity.
价 格：￥电议型 号：T8741产 地：中国大陆
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T9776TRPM4 inhibitor 8hippocampal neurons,Ionotropic glutamate receptors,ERK,Inhibitor,neuroprotective ac
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
价 格：￥电议型 号：T9776产 地：中国大陆
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T9500M435-1279M435 1279,M4351279
M435-1279 is a UBE2T inhibitor. M435-1279 blocks UBE2T-mediated degradation of RACK1, leading to inhibit the hyperactivation of Wnt/β-catenin signaling pathway.
价 格：￥电议型 号：T9500产 地：中国大陆
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T9018JHU37160Inhibitor,hM4Di,Clozapine,hM3Dq,DREADD,inhibit,Muscarinic acetylcholine receptor,JHU-37160,J
JHU 37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
价 格：￥电议型 号：T9018产 地：中国大陆
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T9889M4 mAChR agonist-1?inhibit,M4 mAChR agonist1?,Inhibitor,Muscarinic acetylcholine receptor,mAChR,M4 m
M4 mAChR agonist-1 is an effective agonist of M4 mAChR (EC50 >10 μM).
价 格：￥电议型 号：T9889产 地：中国大陆
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T9245TRPM4-IN-1TRP Channel,Transient receptor potential channels,non-selective,TRPM4IN1,diseases,TRPM4,in
TRPM4-IN-1 is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.
价 格：￥电议型 号：T9245产 地：中国大陆
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T6763XevinapantSM 406,SM406,Xevinapant,AT-406,oral,inhibit,Debio 1143,ovarian,IAP,degradation,Smac,AT 406
AT406 (SM-406, ARRY-334543) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.
价 格：￥电议型 号：T6763产 地：中国大陆
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T5394Prulifloxacin普卢利沙星；Pruvel；NM441；AF 3012
Prulifloxacin is a broad-spectrum fluoroquinolone antibiotic. It Inhibits bacterial DNA synthesis by inhibiting the activity of bacterial DNA topoisomerase II and IV.
价 格：￥电议型 号：T5394产 地：中国大陆
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T5039Aminohippurate sodium4-氨基马尿酸钠盐；Sodium 4-aminohippurate Hydrate；p-Aminohippuric acid sodium salt；Sodi
The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.
价 格：￥电议型 号：T5039产 地：中国大陆
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T20723LGE-899Sonidegib metabolite M48；LGE 899；LGE899
LGE-899 is a main metabolite of Sonidegib which is an inhibitor of the hedgehog pathway. The Tmax of LGE-899(60 h) is much longer than Sonidegib.
价 格：￥电议型 号：T20723产 地：中国大陆
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T15141DM4美登素 DM4；Ravtansine
DM4 can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.
价 格：￥电议型 号：T15141产 地：中国大陆
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T14881CB1 antagonist 2AM4113
CB1 antagonist 2 is caimabinoid 1 (CB1) antagonist extracted from patent WO2016184310A1, compound 3. Which inhibits CB1 in vivo with an IC50 of 25.5 nM.
价 格：￥电议型 号：T14881产 地：中国大陆
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T10814Cinacalcet metabolite M4Rarechem AL BW 1078；3-三氟甲基苯丙胺
Cinacalcet metabolite M4 is a metabolite of Cinacalcet. Cinacalcet is an allosteric agonist of Ca receptor.
价 格：￥电议型 号：T10814产 地：中国大陆
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T10814Cicalcet metabolite M4Cicalcet metabolite M4,Cinacalcet metabolite M4,
Cinacalcet metabolite M4 is a metabolite of Cinacalcet. Cinacalcet is an allosteric agonist of Ca receptor.
价 格：￥电议型 号：T10814产 地：美洲
