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T9041AES-350Histone deacetylases,AES 350,MV4-11,AES-350,Apoptosis,acute myeloid leukemia,AML,Inhibitor,in
AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, and >1μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research.
价 格:¥电议型 号:T9041产 地:中国大陆
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T7596FirocoxibLPS,COX-2,fever,ML1785713,Cyclooxygenase,COX,inhibit,Firocoxib,Inhibitor,anti-inflammatory,
Firocoxib is a selective non-steroidal inhibitor of cycooxygenase-2 (COX-2) (IC50 of 0.13 μM), with anti-inflammatory for use in dogs and horses.
价 格:¥电议型 号:T7596产 地:中国大陆
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T38163ML-148ML-148,ML 148,selective,Inhibitor,prostaglandin-signaling,15-PGDH,15-Hydroxyprostaglandin dehy
ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM). ML-148 can be used to profile across a panel of related dehydrogenase or reductase enzymes and in studies about prostaglandin-signaling pathways.
价 格:¥电议型 号:T38163产 地:中国大陆
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T25824ML400
ML400 is an allosteric inhibitor of LMPTP with an EC50 of 1μM. ML400 displays good cell-based activity and rodent pharmacokinetics.
价 格:¥电议型 号:T25824产 地:中国大陆
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T8990ML266ML266
ML266 is glucocerebrosidase (GCase) molecule chaperone, IC50 = 2.5 ?M. ML266 binds to GCase and transports of the mutant protein to the lysosome, and resume the activity of GCase. ML266 dose not inhibit the GCase enzyme’s action. ML266 has the potential for the research of gaucher disease.
价 格:¥电议型 号:T8990产 地:中国大陆
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T8234ML401ML401,Inhibitor,ML 401,EBI2/GPR183,inhibit,ML-401
ML401 is a selectively EBI2(GPR183) receptor antagonist(IC50 of 1.03 nM) .
价 格:¥电议型 号:T8234产 地:中国大陆
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T23003ML337
ML337 is a negative allosteric modulator of mGlu3 with an IC50 of 593 nM.
价 格:¥电议型 号:T23003产 地:中国大陆
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T7697BIX-01294PRMT1,recurrent,Autophagy,H3K9me3,Inhibitor,Cdkn1a,inhibit,p53,Gadd45a,MLKL,Histone Methylt
BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).
价 格:¥电议型 号:T7697产 地:中国大陆
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T8375ML-210residue,Ferroptosis,inhibit,peroxidase,ML-210,Covalent,selenocysteine,Glutathione Peroxidase,M
ML-210 is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
价 格:¥电议型 号:T8375产 地:中国大陆
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T7593Levomefolate calciumLevomefolate,Inhibitor,Antifolate,inhibit,Levomefolate calcium
Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.
价 格:¥电议型 号:T7593产 地:中国大陆
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T9678ML328ML328,ML-328
ML328 is a potent and selective inhibitor of bacterial AddAB(IC50 = 1.0 μM) and RecBCD(IC50 = 4.8 μM) helicase-nucleases.
价 格:¥电议型 号:T9678产 地:中国大陆
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T28036MI-2-2cell proliferation,inhibit,menin-MLL interaction,Epigenetic Reader Domain,Inhibitor,Hoxa9 expr
MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.
价 格:¥电议型 号:T28036产 地:中国大陆
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T8423ML417neuroprotection,dopaminergic,β-arrestin,ML417,ML-417,translocation,phosphorylation,neurons,ML 4
ML417 is a selective and brain penetrant agonist of D3 Dopamine (EC50 : 38 nM).
价 格:¥电议型 号:T8423产 地:中国大陆
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T6896TolimidoneSrc,Tolimidone,MLR 1023,MLR1023,Inhibitor,inhibit
MLR-1023 is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals.
价 格:¥电议型 号:T6896产 地:中国大陆
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T8371ML188Inhibitor,SARS coronavirus,infection,non-covalent,ML-188,ML 188,ML188,antiviral,SARS-CoV,Virus
ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.
价 格:¥电议型 号:T8371产 地:中国大陆
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T7558CID-1067700ML282,competitively,CID1067700,brain,Rab7,ML 282,GTPase,Ras,machinery,Ras-related,CID-106
CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases(Rab7 with a Ki of 13 nM).
价 格:¥电议型 号:T7558产 地:中国大陆
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T9011VU0155094VU0155094,Inhibitor,Metabotropic glutamate receptors,ML397,inhibit,mGluR
ML397 is a positive allosteric modulator with differential activity at the various group III mGluRs.
价 格:¥电议型 号:T9011产 地:中国大陆
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T6726VU0361737Parkinson’s,inhibit,ML128,neuroprotective,Metabotropic glutamate receptors,VU0361737,Inhibi
VU 0361737 is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 is110 nM for rat receptors.It exhibits weak activity at mGlu5 and mGlu8 receptors, and is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors, can penetrate into CNS.
价 格:¥电议型 号:T6726产 地:中国大陆
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T8838CCI-007CCI 007,MLL-r,CALM-AF10,HOXA9,MEIS1,Apoptosis,CMYC,CCI-007,SET-NUP214,inhibit,Inhibitor,CCI00
CCI 007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485
价 格:¥电议型 号:T8838产 地:中国大陆