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  • T16940STAT5-IN-2STAT-5-IN-2,STAT5IN2,STAT5 IN 2

    STAT5-IN-2 is an inhibitor of STAT5 with antileukemic effects (EC50s: 9 μM and 5 μM in K562 and KU812 cells, respectively).

    价 格：￥电议型 号：T16940产 地：中国大陆

  • T81104SREBP/SCAP-IN-2；化合物 SREBP/SCAP-IN-2SREBP/SCAP-IN-2

    SREBP/SCAP-IN-2 (compound 13) acts as a selective inhibitor of SREBP/SCAP [1].

    价 格：￥电议型 号：T81104产 地：中国大陆

  • T81075SUCNR1-IN-2；化合物 SUCNR1-IN-2SUCNR1-IN-2

    SUCNR1-IN-2 (Statement 35) serves as an inhibitor of both succinate and succinate receptor 1, utilized in research pertaining to neurodegenerative disorders, including neuroinflammation [1].

    价 格：￥电议型 号：T81075产 地：中国大陆

  • T79563Sirt1/2-IN-2；化合物 Sirt1/2-IN-2Sirt1/2-IN-2

    Sirt1/2-IN-2 (compound hsa55) serves as a dual inhibitor for SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM, respectively. It effectively inhibits p53 deacetylation while enhancing the acetylation of p53 and α-tubulin. The compound also promotes apoptosis and exhibits anti-proliferative effects on human leukemia cell lines [1].

    价 格：￥电议型 号：T79563产 地：中国大陆

  • T79185STAT6-IN-2；化合物 STAT6-IN-2STAT6-IN-2

    STAT6-IN-2 (Comp R-84) serves as a STAT6 inhibitor, effectively reducing the secretion of the chemokine eotaxin-3, which is known to induce eosinophil infiltration. This compound is useful in the study of immune diseases [1].

    价 格：￥电议型 号：T79185产 地：中国大陆

  • T74815SLC26A3-IN-2；化合物 SLC26A3-IN-2SLC26A3-IN-2

    SLC26A3-IN-2 is an orally active compound that functions as an inhibitor of the anion exchanger protein SLC26A3, displaying an IC50 of 360 nM. This protein is a member of the solute carrier (SLC) family, specifically the SLC26 family, known for its broad anion specificity, including chloride, bicarbonate, sulfate, and oxalate. SLC26A3, also known as DRA, is typically down-regulated in adenoma and plays a crucial role in the intestinal absorption of chloride and oxalate. Moreover, mutations resul

    价 格：￥电议型 号：T74815产 地：中国大陆

  • T73273SERT-IN-2；化合物 SERT-IN-2SERT-IN-2

    SERT-IN-2, a potent SERT inhibitor (IC 50 = 0.58 nM), exhibits promising efficacy as an anti-depressant. It demonstrates a favorable bioavailability of 83.28% in rats and has the ability to cross the blood-brain barrier.

    价 格：￥电议型 号：T73273产 地：中国大陆

  • T73183SMYD3-IN-2；化合物 SMYD3-IN-2SMYD3-IN-2

    SMYD3-IN-2, a potent inhibitor of SMYD3, demonstrates significant efficacy in combating gastric cancer by promoting lethal autophagy. It exhibits strong inhibitory activity against both SMYD3 and BGC823 cells, with IC 50 values of 0.81 μM and 0.75 μM, respectively. This compound holds potential for cancer research applications.

    价 格：￥电议型 号：T73183产 地：中国大陆

  • T72874sEH/AChE-IN-2；化合物 sEH/AChE-IN-2sEH/AChE-IN-2

    sEH/AChE-IN-2 and acetylcholinesterase ( AChE ). sEH/AChE-IN-2 provides cumulative effects against neuroinflammation and memory impairment. sEH/AChE-IN-2 has the potential for the research of Alzheimer´s disease (AD) [1] .

    价 格：￥电议型 号：T72874产 地：中国大陆

  • T7263SMS2-IN-2；化合物SMS2-IN-2SMS2 inhibitors；SMS2 inhibitors

    SMS2-IN-2 (SMS2 inhibitors) is a potent, selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, (IC50s of 100 and 56 μM for SMS2 and SMS1, respectively). SMS2-IN-2 has anti-chronic inflammatory activity.

    价 格：￥电议型 号：T7263产 地：中国大陆

  • T72581SARS-CoV MPro-IN-2；化合物 SARS-CoV MPro-IN-2SARS-CoV MPro-IN-2

    SARS-CoV MPro-IN-2 effectively inhibits the SARS-CoV-2 main protease (M pro), crucial for the virus´s replication and transcription in host cells, with an IC50 value of 72.07 nM. Given its significant role in processing viral polyproteins, M pro is regarded as a key target in drug discovery efforts. Consequently, SARS-CoV MPro-IN-2 holds promise for COVID-19 research.

    价 格：￥电议型 号：T72581产 地：中国大陆

  • T72231SARS-CoV-2/MERS Mpro-IN-2；化合物 SARS-CoV-2/MERS Mpro-IN-2SARS-CoV-2/MERS Mpro-IN-2

    SARS-CoV-2/MERS Mpro-IN-2 is a potent inhibitor of the main proteases of SARS-CoV-2 and MERS, demonstrating IC50 values of 0.21 and 0.07 ?M, respectively.

    价 格：￥电议型 号：T72231产 地：中国大陆

  • T72043SCFSkp2-IN-2；化合物SCFSkp2-IN-2SCFSkp2-IN-2

    SCFSkp2-IN-2, a Skp2 inhibitor, exhibits a dissociation constant (K_D) of 28.77 μM. It demonstrates antitumor activities by inducing apoptosis in non-small cell lung cancer (NSCLC) cells.

    价 格：￥电议型 号：T72043产 地：中国大陆

  • T63835SphK1-IN-2；化合物 SphK1-IN-2SphK1-IN-2

    SphK1-IN-2 is a potent and selective SphK1 inhibitor that acts on both SphK1 (IC50: 19.81 nM) and SphK2 (IC50>10 nM). sphK1-IN-2 induces cell cycle arrest and apoptosis, exhibits anti-proliferative effects, and can be used to study cancer.

    价 格：￥电议型 号：T63835产 地：中国大陆

  • T63385SARS-CoV-2 3CLpro-IN-2；化合物 SARS-CoV-2 3CLpro-IN-2SARS-CoV-2 3CLpro-IN-2

    SARS-CoV-2 3CLpro-IN-2 is a potent inhibitor of the 3CL protease pair and has shown research potential for SARS-CoV-2 disease.

    价 格：￥电议型 号：T63385产 地：中国大陆

  • T63288SCP1-IN-2；化合物 SCP1-IN-2SCP1-IN-2

    SCP1-IN-2 is a potent, selective, and metric inhibitor of SCP1. SCP1-IN-2 is able to induce REST degradation and inhibit its transcriptional activity. High levels of REST protein induce tumor growth in some glioblastoma cells. sCP1-IN-2 has the potential to perform studies of glioblastomas in which REST transcriptional activity drives growth.

    价 格：￥电议型 号：T63288产 地：中国大陆

  • T63017SphK2-IN-2；化合物 SphK2-IN-2SphK2-IN-2

    SphK2-IN-2 (21g) is a potent and selective inhibitor of SphK2 (IC50: 0.23 μM).

    价 格：￥电议型 号：T63017产 地：中国大陆

  • T62819SARS-CoV-2 nsp14-IN-2；化合物 SARS-CoV-2 nsp14-IN-2SARS-CoV-2 nsp14-IN-2

    SARS-CoV-2 nsp14-IN-2 is a potent inhibitor of SARS-CoV-2 Nsp14 methyltransferase (IC50: 0.093 μM). SARS-CoV-2 nsp14-IN-2 has the potential to be used in COVID-19 studies.

    价 格：￥电议型 号：T62819产 地：中国大陆

  • T62404SHMT-IN-2；化合物SHMT-IN-2SHMT-IN-2

    SHMT-IN-2 (compound 2) is a specific human SHMT1/2 small molecule inhibitor that acts on SHMT1 (IC50: 13 nM) and SHMT2 (IC50: 66 nM). SHMT-IN-2 inhibits the growth of many human cancer cells and is sensitive to B-cell lymphoma.

    价 格：￥电议型 号：T62404产 地：中国大陆

  • T62264SARS-CoV-2 nsp13-IN-2；化合物 SARS-CoV-2 nsp13-IN-2SARS-CoV-2 nsp13-IN-2

    SARS-CoV-2 nsp13-IN-2 (Compound C2) is a small molecule inhibitor of SARS-CoV-2 non-structural protein 13 (nsp13) that acts on nsp13 ssDNA+ATPase (IC50: 42 μM).

    价 格：￥电议型 号：T62264产 地：中国大陆

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