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T8880PFM01Inhibitor,derivative,MRE11,PFM-01,NHEJ,Mirin,DSB,endonuclease,N-alkylated,PFM01,PFM 01,inhibit
PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR).
价 格:¥电议型 号:T8880产 地:中国大陆
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T9168NSC 617145NSC 617145,breaks,NHEJ,helicase,DSB,abnormalities,WRN,DNA/RNA Synthesis,strand,Rad51,chrom
NSC617145 is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner.
价 格:¥电议型 号:T9168产 地:中国大陆
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T74501NHEJ inhibitor-1;化合物 NHEJ inhibitor-1NHEJ inhibitor-1
NHEJ Inhibitor-1 (Compound C2), a trifunctional Pt(II) complex, mitigates non-homologous end joining (NHEJ)/homologous recombination (HR)-related double strand break (DSB) repairs, combating Cisplatin resistance in non-small cell lung cancer (NSCLC). It achieves this by inhibiting the damage repair proteins Ku70 and Rad51, thus re-sensitizing tumors to Cisplatin. Additionally, this compound prompts the generation of reactive oxygen species (ROS) and reduces mitochondrial membrane potential (MMP)
价 格:¥电议型 号:T74501产 地:中国大陆