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T12253Nrf2-IN-1
Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).
价 格：￥电议型 号：T12253产 地：中国大陆
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T12253Nrf2-IN-1Nrf2-IN-1
Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor.
价 格：￥电议型 号：T12253产 地：美洲
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T81984Keap1-Nrf2-IN-10；化合物 Keap1-Nrf2-IN-10Keap1-Nrf2-IN-10
Keap1-Nrf2-IN-10 (compound 15) is a potent inducer of NQO1 and efficaciously mitigates oxidative stress in gamma-irradiated mice by reducing MDA and ROS levels, as well as NQO1 in the liver, which enhances the survival rate of these mice [1].
价 格：￥电议型 号：T81984产 地：中国大陆
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T80260Keap1-Nrf2-IN-16；化合物 Keap1-Nrf2-IN-16Keap1-Nrf2-IN-16
Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.
价 格：￥电议型 号：T80260产 地：中国大陆
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T78697Keap1-Nrf2-IN-15；化合物 Keap1-Nrf2-IN-15Keap1-Nrf2-IN-15
Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescence polarization (FP) assay and 2.5 nM in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay [1].
价 格：￥电议型 号：T78697产 地：中国大陆
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T72706Keap1-Nrf2-IN-13；化合物 Keap1-Nrf2-IN-13Keap1-Nrf2-IN-13
Keap1-Nrf2-IN-13 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI), exhibiting an IC50 value of 0.15 μM, indicative of its high efficacy. It binds strongly to the Keap1 protein by forming hydrogen bonds with critical polar residues (Asn414, Arg415, Arg483, Gln530), showcasing its specificity. This compound has implications for research into diseases associated with oxidative stress and inflammation, such as pulmonary fibrosis, chronic obstructive pulmonary disorder (COPD)
价 格：￥电议型 号：T72706产 地：中国大陆
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T72687Keap1-Nrf2-IN-11；化合物 Keap1-Nrf2-IN-11Keap1-Nrf2-IN-11
Keap1-Nrf2-IN-11 (Compound 6k), a potent Keap1-Nrf2 inhibitor, exhibits a dissociation constant (KD) of 0.21 nM. It hampers the production of reactive oxygen species (ROS) and nitric oxide (NO), as well as the expression of tumor necrosis factor-alpha (TNF-α). By promoting Nrf2 nuclear translocation, it mitigates inflammation and is utilized in anti-inflammatory studies [1].
价 格：￥电议型 号：T72687产 地：中国大陆
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T64218Keap1-Nrf2-IN-1 TFA；化合物 Keap1-Nrf2-IN-1 TFAKeap1-Nrf2-IN-1 TFA
Keap1-Nrf2-IN-1 TFA (compound35) is a Keap1-Nrf2 protein-protein interaction inhibitor (IC50: 43 nM) that activates Nrf2-regulated cytoprotective responses. Keap1-Nrf2-IN-1 TFA antagonizes acetaminophen-induced liver injury in cellular and in vivo models.
价 格：￥电议型 号：T64218产 地：中国大陆
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T64190Keap1-Nrf2-IN-12；化合物 Keap1-Nrf2-IN-12Keap1-Nrf2-IN-12
eap1-Nrf2-IN-12 is a potent inhibitor of Keap1-Nrf2 (IC50: 2.30 μM). eap1-Nrf2-IN-12 is metabolically stable in human liver microsomes.
价 格：￥电议型 号：T64190产 地：中国大陆
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T63987Keap1-Nrf2-IN-14；化合物 Keap1-Nrf2-IN-14Keap1-Nrf2-IN-14
Keap1-Nrf2-IN-14 is a KEAP1-NRF2 inhibitor that effectively disrupts the KEAP1-NRF2 interaction (IC50: 75 nM) with a Kd=24 nM for KEAP1. Keap1-Nrf2-IN-14 induces the expression of NRF2 target genes and is able to enhance downstream antioxidant and anti-inflammatory effects. -Nrf2-IN-14 can be used to study oxidative stress-related inflammation.
价 格：￥电议型 号：T63987产 地：中国大陆
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T12253Nrf2-IN-1；化合物Nrf2-IN-1Nrf2-IN-1
Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).
价 格：￥电议型 号：T12253产 地：中国大陆
