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T9786Lu AF27139Inhibitor,P2XRs,oral,P2X7,rodent-active,Lu AF 27139,CNS-penetrant,CNS,Lu AF27139,Lu AF-271
Lu AF27139 is an effective and selective antagonist of P2X7 receptor (IC50s of 12 and 2.4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and rat, respectively). Lu AF27139 can be used in CNS diseases studies.
价 格：￥电议型 号：T9786产 地：中国大陆
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T81579P2X7 receptor antagonist-4；化合物 P2X7 receptor antagonist-4P2X7 receptor antagonist-4
Compound 14a (P2X7 receptor antagonist-4) is a P2X7R antagonist with IC50 values of 64.7 nM in humans and 10.1 nM in mice. It inhibits the activation of the NLRP3 inflammasome, which subsequently reduces the expression of caspase-1, gasdermin D, IL-1β, and IL-18 in the kidneys of mice with sepsis-induced damage [1].
价 格：￥电议型 号：T81579产 地：中国大陆
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T75254P2X7-IN-2 TFA；化合物 P2X7-IN-2 TFAP2X7-IN-2 TFA
P2X7-IN-2 TFA (compound 58) is a P2X7 receptor inhibitor that demonstrates the capability to inhibit IL-Iβ release effectively with an IC50 value of 0.01 nM. It is utilized in research focused on autoimmunity, inflammation, and cardiovascular disease [1].
价 格：￥电议型 号：T75254产 地：中国大陆
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T73335P2X7-IN-2；化合物 P2X7-IN-2P2X7-IN-2
P2X7-IN-2, a P2X7 receptor inhibitor, effectively suppresses IL-Iβ release, demonstrating an inhibitory concentration (IC50) value of 0.01 nM. This compound is utilized in the study of autoimmunity, inflammation, and cardiovascular disease.
价 格：￥电议型 号：T73335产 地：中国大陆
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T72198P2X7 receptor antagonist-3；化合物 P2X7 receptor antagonist-3P2X7 receptor antagonist-3
P2X7 receptor antagonist-3 is a powerful inhibitor of the P2X7 receptor, exhibiting IC50 values of 4.2 nM in humans and 6.8 nM in rats, indicating its high potency in both species.
价 格：￥电议型 号：T72198产 地：中国大陆
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T62488P2X7 receptor antagonist-1；化合物 P2X7 receptor antagonist-1P2X7 receptor antagonist-1
P2X7 receptor antagonist-1 is a purinergic P2X7 receptor antagonist with anti-neuroinflammatory effects.
价 格：￥电议型 号：T62488产 地：中国大陆
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T61566P2X7 receptor antagonist-2；化合物 P2X7 receptor antagonist-2P2X7 receptor antagonist-2
P2X7 receptor antagonist-2 is a highly potent antagonist of the P2X7 receptor, exhibiting a pIC50 value range of 6.5-7.5. Its efficacy in combating neuroinflammation has been demonstrated [1].
价 格：￥电议型 号：T61566产 地：中国大陆
