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T9616PD-1/PD-L1-IN-10Lewis,T-lymphocyte,tumor,IFN-γ,Inhibitor,lung,LLC,inhibit,Apoptosis,PD1/PDL1IN10,PD
PD-1/PD-L1-IN-10 is an orally active?PD-1/PD-L1?inhibitor (IC50?of 2.7 nM) with potent anticancer efficacy.
价 格：￥电议型 号：T9616产 地：中国大陆
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T79738CYP51/PD-L1-IN-1；化合物 CYP51/PD-L1-IN-1CYP51/PD-L1-IN-1
CYP51/PD-L1-IN-1 (compound L11), a quinazoline with antifungal properties, simultaneously inhibits CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM). This compound prompts early apoptosis in the fungal cell cycle, markedly diminishes intracellular IL-2, NLRP3, and NF-κBp65 protein concentrations, causes mitochondrial damage and ROS accumulation, and culminates in fungal lysis and cell death [1].
价 格：￥电议型 号：T79738产 地：中国大陆
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T72670PD-1/PD-L1-IN-13；PD-1/PD-L1-IN-13PD-1/PD-L1-IN-13
PD-1/PD-L1-IN-13 is a potent immune checkpoint PD-1/PD-L1 inhibitor with an IC50 value of 10.2 nM for PD-1/PD- L1 interaction.PD-1/PD-L1-IN-13 promotes CD8+ T-cell activation and delays tumour growth in a Hepa1-6 homozygous mouse model.
价 格：￥电议型 号：T72670产 地：中国大陆
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T63948PD-1/PD-L1-IN-16；化合物 PD-1/PD-L1-IN-16PD-1/PD-L1-IN-16
PD-1/PD-L1-IN-16 is a potent inhibitor of PD-1/PD-L1 (IC50: 53.2 nM) and has shown research potential for tumour immunotherapy.
价 格：￥电议型 号：T63948产 地：中国大陆
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T63614PD-1/PD-L1-IN-15；化合物 PD-1/PD-L1-IN-15PD-1/PD-L1-IN-15
PD-1/PD-L1-IN-15 is a potent inhibitor of PD-1/PD-L1 (IC50: 60.1 nM) and has shown investigational potential for tumor immunotherapy.
价 格：￥电议型 号：T63614产 地：中国大陆
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T62501PD-1/PD-L1-IN-17；化合物 PD-1/PD-L1-IN-17PD-1/PD-L1-IN-17
PD-1/PD-L1-IN-17 (Compound P20) is a potent PD-1/PD-L1 inhibitor (IC50: 26.8 nM). PD-1/PD-L1-IN-17 is a promising lead compound for the development of inhibitors of PD-1/PD-L1 interactions. -17 has potential for cancer disease research.
价 格：￥电议型 号：T62501产 地：中国大陆
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T61929PD-1/PD-L1-IN-14；化合物 PD-1/PD-L1-IN-14PD-1/PD-L1-IN-14
PD-1/PD-L1-IN-14 (compound 17) is an inhibitor of PD-1/PD-L1 interaction (IC50=27.8 nM). By inhibiting the interaction of PD-1/PD-L1, PD-1/PD-L1-IN-14 promotes dimerization, endocytosis and degradation of PD-L1.
价 格：￥电议型 号：T61929产 地：中国大陆
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T61574PD-L1-IN-1；化合物 PD-L1-IN-1PD-L1-IN-1
PD-L1-IN-1, a powerful PD-L1 inhibitor, demonstrated an IC50 of 115 nM. By forming a robust bond with the PD-L1 protein, PD-L1-IN-1 effectively suppressed tumor growth by enhancing the antitumor immune activity of peripheral blood mononuclear cells in co-cultures with PD-L1 expressing cancer cells (PC9 and HCC827 cells). It significantly elevated the release of interferon γ and induced apoptosis in cancer cells, while exhibiting minimal cytotoxicity in healthy cells [1].
价 格：￥电议型 号：T61574产 地：中国大陆
