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  • T9616PD-1/PD-L1-IN-10Lewis,T-lymphocyte,tumor,IFN-γ,Inhibitor,lung,LLC,inhibit,Apoptosis,PD1/PDL1IN10,PD

    PD-1/PD-L1-IN-10 is an orally active?PD-1/PD-L1?inhibitor (IC50?of 2.7 nM) with potent anticancer efficacy.

    价 格：￥电议型 号：T9616产 地：中国大陆

  • T9651PD-1/PD-L1-IN-9PD1/PDL1IN9,PD 1/PD L1 IN 9

    PD-1/PD-L1-IN-9 is a potent and orally active inhibitor of PD-1/PD-L1 interaction, IC50 = 3.8 nM. PD-1/PD-L1-IN-9 can enhance the killing activity of tumor cells by immune cells. PD-1/PD-L1-IN-9 also exhibits significant in vivo antitumor activity in a CT26 mouse model.

    价 格：￥电议型 号：T9651产 地：中国大陆

  • T4696BMS202 hydrochloride (1675203-84-5(free base))PD-1/PD-L1 inhibitor 2 hydrochloride

    PD-1/PD-L1 inhibitor 2 is a small-molecule PD-1/PD-L1 interaction inhibitor (IC50: 18 nM). Biophysical studies demonstrate that BMS202 binds directly to PD-L1. Binding of BMS202 promotes PD-L1 dimerisation and blocks the PD-L1/ PD1 interaction.

    价 格：￥电议型 号：T4696产 地：中国大陆

  • T3655BMS-1PD1-PDL1 inhibitor 1；PD-1/PD-L1 inhibitor 1

    PD1-PD-L1 inhibitor 1 (PD1-PD-L1-IN-1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. It also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene and the upregulation of PD-

    价 格：￥电议型 号：T3655产 地：中国大陆

  • T3146BMS-202PD1-PDL1 inhibitor 2；PD-1/PD-L1 inhibitor 2

    PD1-PDL1 inhibitor 2 is an inhibitor of the PD-1 (Programmed death- 1) /PD-Ll (Programmed death-ligand 1) protein/protein interaction, extracted from patent WO/2015034820 A1.

    价 格：￥电议型 号：T3146产 地：中国大陆

  • T83724TPP-1 hydrochloride；化合物 TPP-1 hydrochlorideTargeting PD-L1 Peptide；Targeting PD-L1 Peptide

    TPP-1, a peptide inhibitor, targets the interaction between programmed cell death protein 1 (PD-1) and its ligand (PD-L1), binding specifically to PD-L1 with a dissociation constant (Kd) of 94.67 nM. At a concentration of 20 ?M, TPP-1 effectively counteracts the PD-L1-induced suppression of IFN-γ production in anti-CD3-stimulated isolated human CD4+ T cells. Furthermore, TPP-1 demonstrates significant efficacy in reducing tumor volume in a mouse xenograft model of HL-60 leukemia. This model invo

    价 格：￥电议型 号：T83724产 地：中国大陆

  • T80209Human membrane-bound PD-L1 polypeptide；化合物 Human membrane-bound PD-L1 polypeptideHuman membrane-boun

    Human membrane-bound PD-L1 polypeptide serves as an antigen for inducing the production of PD-L1 antibodies [1].

    价 格：￥电议型 号：T80209产 地：中国大陆

  • T79740CYP51/PD-L1-IN-3；化合物 CYP51/PD-L1-IN-3CYP51/PD-L1-IN-3

    CYP51/PD-L1-IN-3 (compound L21), a quinazoline with antifungal properties, serves as a dual inhibitor targeting CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM). This compound promotes early fungal apoptosis within the cell cycle, diminishes intracellular concentrations of IL-2, NLRP3, and NF-κBp65 proteins, incites mitochondrial impairment and ROS accumulation, and culminates in fungal cell lysis and death [1].

    价 格：￥电议型 号：T79740产 地：中国大陆

  • T79739CYP51/PD-L1-IN-2；化合物 CYP51/PD-L1-IN-2CYP51/PD-L1-IN-2

    CYP51/PD-L1-IN-2 (compound L20), a quinazoline with antifungal properties, is a potent dual inhibitor targeting both CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.017 μM). The compound promotes early apoptosis in the fungal cell cycle, markedly diminishes intracellular proteins IL-2, NLRP3, and NF-κBp65, causes mitochondrial damage and ROS build-up, culminating in fungal cell lysis and death [1].

    价 格：￥电议型 号：T79739产 地：中国大陆

  • T79738CYP51/PD-L1-IN-1；化合物 CYP51/PD-L1-IN-1CYP51/PD-L1-IN-1

    CYP51/PD-L1-IN-1 (compound L11), a quinazoline with antifungal properties, simultaneously inhibits CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM). This compound prompts early apoptosis in the fungal cell cycle, markedly diminishes intracellular IL-2, NLRP3, and NF-κBp65 protein concentrations, causes mitochondrial damage and ROS accumulation, and culminates in fungal lysis and cell death [1].

    价 格：￥电议型 号：T79738产 地：中国大陆

  • T79643PD-1/PD-L1-IN-33；化合物 PD-1/PD-L1-IN-33PD-1/PD-L1-IN-33

    PD-1/PD-L1-IN-33 (Compound N11), a PD-1/PD-L1 inhibitor, effectively impedes the interaction between PD-1 and PD-L1 with an IC50 of 6.3 nM. By doing so, it enhances T-cell proliferation, activation, and infiltration within tumor environments, exhibiting immunomodulatory and anticancer properties [1].

    价 格：￥电议型 号：T79643产 地：中国大陆

  • T79576PD-1/PD-L1-IN-32；化合物 PD-1/PD-L1-IN-32PD-1/PD-L1-IN-32

    PD-1/PD-L1-IN-32 (compound A56) is a potent inhibitor of PD-1/PD-L1, displaying pronounced anticancer activity with an IC50 value of 2.4 nM. It effectively suppresses tumor growth in the hPD-L1 MC38 humanized mouse model and exhibits negligible toxicity to the mice´s normal functions [1].

    价 格：￥电议型 号：T79576产 地：中国大陆

  • T79314PD-L1-IN-3；化合物 PD-L1-IN-3PD-L1-IN-3

    PD-L1-IN-3 (Compound 4a) functions as an inhibitor targeting the PD-1/PD-L1 axis, with an IC50 value of 4.97nM for PD-L1 inhibition and an EC50 value of 2.70 μM for Jurkat T cell modulation. It antagonizes the PD-1/PD-L1 interaction by binding to the PD-L1 dimer, obstructing PD-1 signaling. This compound is utilized in research pertaining to lung cancer and melanoma [1].

    价 格：￥电议型 号：T79314产 地：中国大陆

  • T79205PD-1/PD-L1-IN-34；化合物 PD-1/PD-L1-IN-34PD-1/PD-L1-IN-34

    PD-1/PD-L1-IN-34 (Compound (1S,2S)-A25) effectively inhibits the PD-1/PD-L1 interaction (IC 50 = 0.029 μM) and demonstrates selective binding affinity to PD-L1 (K D = 0.1554 μM), resulting in the activation of the immune microenvironment and suppression of tumor growth [1].

    价 格：￥电议型 号：T79205产 地：中国大陆

  • T78902CYP51/PD-L1-IN-4；化合物 CYP51/PD-L1-IN-4CYP51/PD-L1-IN-4

    CYP51/PD-L1-IN-4 (compound 14a-2) is a potent dual-target inhibitor of CYP51/PD-L1, displaying IC50 values of 0.17 and 0.021 μM, respectively. This compound demonstrates significant antifungal efficacy and combats drug-resistant fungal strains in vitro, making it a valuable agent for fungal infection research [1].

    价 格：￥电议型 号：T78902产 地：中国大陆

  • T78755PD-1/PD-L1-IN-31；化合物 PD-1/PD-L1-IN-31PD-1/PD-L1-IN-31

    PD-1/PD-L1-IN-31 is a potent inhibitor of PD-1/PD-L1 (IC50=2.2 nM) that enhances IFN-γ secretion and activates the immune response of peripheral blood mononuclear cells (PBMCs), resulting in the inhibition of tumor cells [1].

    价 格：￥电议型 号：T78755产 地：中国大陆

  • T78270Anti-Mouse PD-L1 Antibody (10F.9G2)；化合物 Anti-Mouse PD-L1 Antibody (10F.9G2)Anti-Mouse PD-L1 Antibody

    Anti-Mouse PD-L1 Antibody is a rat-derived IgG2b monoclonal antibody that inhibits mouse PD-L1.

    价 格：￥电议型 号：T78270产 地：中国大陆

  • T78053PD-L1-IN-2；化合物 PD-L1-IN-2PD-L1-IN-2

    PD-L1-IN-2, a Naamidine J derivative, serves as a promising antineoplastic immunomodulator by hindering PD-L1 activity. In vivo studies indicate that it suppresses PD-L1 expression and amplifies tumor-infiltrating T-cell response, thus exerting anticancer effects. This compound is particularly utilized in the investigation of colorectal cancer [1].

    价 格：￥电议型 号：T78053产 地：中国大陆

  • T76080LHuman PD-L1 inhibitor V TFA；化合物 Human PD-L1 inhibitor V TFAHuman PD-L1 inhibitor V TFA

    Human PD-L1 Inhibitor V TFA, a peptide that binds to the human PD-1 protein, exhibits a dissociation constant (Kd) of 3.32 μM and effectively inhibits the hPD-1/hPD-L1 interaction [1].

    价 格：￥电议型 号：T76080L产 地：中国大陆

  • T76080Human PD-L1 inhibitor V；化合物 Human PD-L1 inhibitor VHuman PD-L1 inhibitor V

    Human PD-L1 Inhibitor V is a peptide that binds to the human PD-1 protein with an affinity characterized by a dissociation constant (Kd) of 3.32 μM, effectively inhibiting the hPD-1/hPD-L1 interaction [1].

    价 格：￥电议型 号：T76080产 地：中国大陆

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