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  • T36832PDE4B-IN-2

    PDE4B-IN-2 is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 ?M). PDE4B-IN-2 exhibits potent anti-inflammatory effects.

    价 格：￥电议型 号：T36832产 地：中国大陆

  • T6427ButeinPDE4,Epidermal growth factor receptor,Inhibitor,EGFR,MAPK,ErbB-1,Apoptosis,Autophagy,FoxO3a,in

    Butein, a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.

    价 格：￥电议型 号：T6427产 地：中国大陆

  • T39341FCPR03antidepressant-like,FCPR-03,PDE4B1,FCPR 03,PDE4D7,PDE4,neuroprotective,ischemic,FCPR03,AKT,GSK

    FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepressant-like effects.

    价 格：￥电议型 号：T39341产 地：中国大陆

  • T7954YM976YM-976,Phosphodiesterase (PDE),PDE4 inhibitor,inhibit,phosphodiesterase 4,anti-inflammatory act

    YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)

    价 格：￥电议型 号：T7954产 地：中国大陆

  • T79624PDE4-IN-14；化合物 PDE4-IN-14PDE4-IN-14

    PDE4-IN-14 (Compound 1) serves as an inhibitor of phosphodiesterase 4 (PDE4), applicable in research concerning diseases associated with PDE4, including inflammatory and immune disorders, cancer, and metabolic diseases [1].

    价 格：￥电议型 号：T79624产 地：中国大陆

  • T79618M3/PDE4 modulator-1；化合物 M3/PDE4 modulator-1M3/PDE4 modulator-1

    M3/PDE4 Modulator-1 (compound 10f) serves as a bifunctional entity functioning both as an M3 mAChR antagonist and a PDE4 inhibitor. When administered intravenously at concentrations ranging from 10 to 1000 nM/kg, this compound effectively diminishes eosinophil influx into cysts within the OVA rat model [1].

    价 格：￥电议型 号：T79618产 地：中国大陆

  • T79538PDE4-IN-13；化合物 PDE4-IN-13PDE4-IN-13

    PDE4-IN-13 is a phosphodiesterase 4 (PDE4) inhibitor exhibiting anti-inflammatory and antioxidant activities, with an half maximal inhibitory concentration (IC50) value of 1.56 μM. It is used in the research of chronic obstructive pulmonary disease (COPD) [1].

    价 格：￥电议型 号：T79538产 地：中国大陆

  • T64005PDE4B-IN-3；化合物 PDE4B-IN-3PDE4B-IN-3

    PDE4B-IN-3 is a potent inhibitor of PDE4B (IC50: 0.94 μM) and exhibits anti-inflammatory effects.

    价 格：￥电议型 号：T64005产 地：中国大陆

  • T63912PDE4-IN-12；化合物 PDE4-IN-12PDE4-IN-12

    PDE4-IN-12 is a potent and safe PDE4 ubiquitous inhibitor that acts on PDE4 (IC50: 3.5 nM, SI: 2.71) and PDE7 (IC50: 15 nM, SI: 4.27).

    价 格：￥电议型 号：T63912产 地：中国大陆

  • T62969PDE4-IN-6；化合物 PDE4-IN-6PDE4-IN-6

    PDE4-IN-6 is a safe, potent and moderately selective inhibitor of PDE4, acting on PDE4B (IC50: 0.125 μM) and PDE4D (IC50: 0.43 μM). PDE4-IN-6 is able to down-regulate TNF-α and IL-6 expression levels, exhibits anti-inflammatory and anti-arthritic effects, and has potent immunomodulatory activity. PDE4-IN-6 has potential for anti-rheumatoid arthritis studies.

    价 格：￥电议型 号：T62969产 地：中国大陆

  • T62303PDE4B/7A-IN-1；化合物 PDE4B/7A-IN-1PDE4B/7A-IN-1

    Compound 22, a 5-hydroxynitrile rubber 7 receptor antagonist (5-HT1A Ki=8 nm, Kb=0.04 nm; 5-nitrile rubber 7K I=451 nm, Kb=460 nm), exhibits inhibitory activity against PDE4B/PDE7A (PDE4B IC50=80.4 μM; PDE7A IC50=151.3 μM). It demonstrates significant passive biofilm penetration capabilities and high metabolic stability in vitro. Pharmacological assessment has revealed precognitive and antidepressant effects in rat behavioral tests, highlighting its potential therapeutic applications.

    价 格：￥电议型 号：T62303产 地：中国大陆

  • T62064PDE4B/7A-IN-2；化合物 PDE4B/7A-IN-2PDE4B/7A-IN-2

    This compound is a dual 5-HT1A/5-HT7 receptor antagonist (5-HT1A Ki = 8 nM, Kb = 0.04 nM; 5-HT7 Ki = 451 nM, Kb = 460 nM) with additional inhibitory activity against PDE4B/PDE7A (PDE4B IC50 = 80.4 μM; PDE7A IC50 = 151.3 μM). Its antidepressant-like effect surpasses that of the reference agent, escitalopram.

    价 格：￥电议型 号：T62064产 地：中国大陆

  • T61620AChE/PDE4-IN-1；化合物 AChE/PDE4-IN-1AChE/PDE4-IN-1

    AChE/PDE4-IN-1 (compound 12c) is a highly effective and specific dual inhibitor of PDE4 and AChE, with IC50 values of 0.28 μM and 1.88 μM for AChE and PDE4D, respectively. This compound demonstrates notable potential in reducing neuroinflammation associated with Alzheimer´s disease research [1].

    价 格：￥电议型 号：T61620产 地：中国大陆

  • T61295PDE4-IN-5；化合物 PDE4-IN-5PDE4-IN-5

    PDE4-IN-5 (compound 33a) is a highly potent and selective inhibitor of the enzyme PDE4, with an IC50 value of 3.1 nM. It exhibits excellent skin permeability and its binding mechanism has been extensively characterized. Additionally, PDE4-IN-5 demonstrates a notable anti-psoriasis effect [1].

    价 格：￥电议型 号：T61295产 地：中国大陆

  • T61208PDE4-IN-11；化合物 PDE4-IN-11PDE4-IN-11

    PDE4-IN-11 is a potent phosphodiesterase isoenzyme 4 (PDE4) inhibitor, exhibiting remarkable bronchodilatory and anti-inflammatory characteristics. It is specifically designed for studying obstructive or inflammatory airway diseases [1] [2] [3].

    价 格：￥电议型 号：T61208产 地：中国大陆

  • T60934PDE4-IN-9；化合物 PDE4-IN-9PDE4-IN-9

    PDE4-IN-9 (Compound 5j) is a potent PDE4 inhibitor. In vitro enzyme assay, the IC 50 value of PDE4-IN-9 against PDE4 is 1.4 μM which is lower than 2.0 μM of parent rolipram. PDE4-IN-9 also shows good in vivo activity in LPS-induced animal models of asthma/COPD and sepsis [1].

    价 格：￥电议型 号：T60934产 地：中国大陆

  • T60920PDE4-IN-8；化合物 PDE4-IN-8PDE4-IN-8

    PDE4-IN-8 (Example 5) is a potent Phosphodiesterase 4 (PDE4) inhibitor. The IC50 value of PDE4-IN-8 for PDE4B2 is 0.93 nM. However, PDE4-IN-8 has little effect on IL13, IL4, and IFNy with IC50 values of 4.04 nM, 36.33 nM, and 2394 nM, respectively [1].

    价 格：￥电议型 号：T60920产 地：中国大陆

  • T60346PDE4-IN-10；化合物 PDE4-IN-10PDE4-IN-10

    PDE4-IN-10 (compound 7a) is a potent inhibitor of PDE4, with an IC 50 of 7.01 μM for PDE4B. PDE4-IN-10 exhibits selectivity, microsomal stability, inhibition of TNF-α and no major toxicities in vitro [1].

    价 格：￥电议型 号：T60346产 地：中国大陆

  • T50023PDE4-IN-20；PDE4 抑制剂 20PDE4-IN-20

    ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate, also known as EAPT, is a potent and selective PDE4 inhibitor that regulates intracellular cyclic adenosine monophosphate (cAMP) levels. It has been used in a variety of scientific applications, including the study of cAMP-mediated signaling pathways, and has potential as a therapeutic agent for the treatment of inflammatory and immune-related diseases.

    价 格：￥电议型 号：T50023产 地：中国大陆

  • T40356PDE4-IN-3PDE4-IN-3PDE4-IN-3

    PDE4-IN-3 is a newly developed oral compound that acts as a potent inhibitor of the enzyme phosphodiesterase 4 (PDE4), displaying a high affinity for inhibition with an IC50 value of 4.2 nM.

    价 格：￥电议型 号：T40356产 地：中国大陆

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