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TP1957LPKI (5-24) Acetate(99534-03-9 free base)PKI (524) Acetate(99534039 free base),PKI (5 24) Acetate(995
PKI (5-24) Acetate is a high affinity PKA inhibitor (Ki = 2.3 nM).
价 格:¥电议型 号:TP1957L产 地:中国大陆
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T12347p38-α MAPK-IN-1Inhibitor,inhibit,p-38-α MAPK-IN-1,Autophagy,p38α MAPKIN1,p38 MAPK,p38 α MAPK IN 1
p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.
价 格:¥电议型 号:T12347产 地:中国大陆
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T21983LPKI 14-22 amide, myristoylated AcetatePKI 14-22 amide, myristoylated Acetate(201422-03-9 Free base)
PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP.?
价 格:¥电议型 号:T21983L产 地:中国大陆
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T1970GedatolisibPKI-587;PF-05212384
Gedatolisib is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling pathway.
价 格:¥电议型 号:T1970产 地:中国大陆
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T1970GedatolisibGedatolisib,PF-05212384,PKI-587
Gedatolisib is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling pathway.
价 格:¥电议型 号:T1970产 地:美洲
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T6154SU11274SU11274,PKI-SU11274,Met Kinase Inhibitor
SU11274(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.
价 格:¥电议型 号:T6154产 地:美洲
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T81447PKItide;化合物 PKItidePKItide
PKItide demonstrates an inhibitory concentration 50 (IC50) of 0.2 μM against cAMP-dependent protein kinase (cAMP-PK) [1].
价 格:¥电议型 号:T81447产 地:中国大陆
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T76482PKI (5-24),amide;化合物 PKI (5-24),amidePKI (5-24),amide
PKI (5-24),amide (IP20-amide) is a potent inhibitor of cAMP-dependent protein kinase (PKA) (PKA), with an inhibition constant (K i ) of 2.3 nM [1]. This 20-residue peptide mirrors the active segment of the heat-stable inhibitor protein specific to PKA, showcasing its significant inhibitory efficacy.
价 格:¥电议型 号:T76482产 地:中国大陆
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T76481LPKI (14-24)amide TFA;化合物 PKI (14-24)amide TFAPKI (14-24)amide TFA
PKI (14-24)amide TFA, a potent inhibitor of Protein Kinase A (PKA), significantly reduces cyclic AMP-dependent protein kinase activity within cellular homogenates, as evidenced by research findings [1] [2].
价 格:¥电议型 号:T76481L产 地:中国大陆
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T76481PKI (14-24)amide;化合物 PKI (14-24)amidePKI (14-24)amide
PKI (14-24)amide is a potent inhibitor of Protein Kinase A (PKA), demonstrating strong inhibition of cyclic AMP-dependent protein kinase activity in cell homogenates [1] [2].
价 格:¥电议型 号:T76481产 地:中国大陆
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T76399PKI(5-22)amide;化合物 PKI(5-22)amidePKI(5-22)amide
PKI(5-22)amide, an active inhibitory fragment of the cyclic AMP-dependent protein kinase (PKA) inhibitor, effectively prevents PKA activation. However, it does not reduce the homologous desensitization of CRF1 receptors [1] [2].
价 格:¥电议型 号:T76399产 地:中国大陆
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T75889PKI 14-22 amide,myristoylated TFA;化合物 PKI 14-22 amide,myristoylated TFAPKI 14-22 amide,myristoylated
PKI 14-22 amide, myristoylated TFA is a potent inhibitor of cAMP-dependent protein kinase A (PKA) that diminishes IgG-mediated phagocytic response and inhibits neutrophil adhesion [1].
价 格:¥电议型 号:T75889产 地:中国大陆
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T75888PKA Inhibitor Fragment (6-22) amide TFA;PKA Inhibitor Fragment (6-22) amide三氟乙酸盐PKI-(6-22)-amide TFA
PKA Inhibitor Fragment (6-22) amide TFA (PKA Inhibitor Fragment (6-22) amide TFA) is an inhibitor of the highly potent cAMP-dependent protein kinase A (PKA) inhibitor (Ki: 2.8 nM).PKA Inhibitor Fragment (6-22) amide TFA reverses the pain-relieving effects of low levels of morphine in mice.
价 格:¥电议型 号:T75888产 地:中国大陆
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T75739PKI(5-24) TFA;化合物 PKI(5-24) TFAPKI(5-24) TFA
PKI(5-24) TFA is a synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), characterized by its potent and competitive inhibition properties, exhibiting a K i of 2.3 nM. It corresponds to residues 5-24 found in the natural heat-stable protein kinase inhibitor [1] [2].
价 格:¥电议型 号:T75739产 地:中国大陆
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T6154SU11274;化合物SU11274Met Kinase Inhibitor|||PKI-SU11274;Met Kinase Inhibitor|||PKI-SU11274
SU11274 (Met Kinase Inhibitor)(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.
价 格:¥电议型 号:T6154产 地:中国大陆
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T36643PKI-166 hydrochloridePKI 166 hydrochloridePKI166 hydrochloride|||PKI 166 hydrochloride
Potent EGFR-kinase inhibitor (IC50 = 0.7 nM). Displays >3000-fold selectivity against a panel of serine/threonine kinases. Reduces metastasis and angiogenesis in a mouse model of pancreatic cancer. Antihypertensive and orally bioavailable.
价 格:¥电议型 号:T36643产 地:中国大陆
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T3656PKI-402;化合物PKI-402PKI-402
PKI-402 is a potent PI3K and mTOR inhibitor. PKI-402 inhibits PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ with IC50s of 2, 3, 7, 14 and 16 nM, respectively.
价 格:¥电议型 号:T3656产 地:中国大陆
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T36085PKI-179 hydrochloride;PKI-179 (hydrochloride)PKI-179 hydrochloride
PKI-179 is an orally bioavailable dual inhibitor of PI3K and mammalian target of rapamycin (mTOR). In an in vitro enzymatic assay, it potently inhibits PI3K (IC50s = 8, 24, 17, and 74 nM for isoforms α, β, δ, and γ, respectively), two common PI3Kα mutants, E545K and H1047R (IC50s = 14 and 11 nM, respectively), and mTOR (IC50 = 0.42 nM). PKI-179 is selective for PI3K and mTOR over a panel of 361 other kinases at IC50 values up to 50 μM, hERG (IC50 > 30 μM), and cytochrome P450 (CYP) isoforms (IC5
价 格:¥电议型 号:T36085产 地:中国大陆
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T36084PKI-179;PKI-179PKI-179
PKI-179 is a potent, orally active compound that functions as a dual PI3K/mTOR inhibitor. It demonstrates IC50 values of 8 nM for PI3K-α, 24 nM for PI3K-β, 74 nM for PI3K-γ, 77 nM for PI3K-δ, and 0.42 nM for mTOR. Additionally, it is effective against E545K and H1047R mutations, with IC50s of 14 nM and 11 nM, respectively. In vivo studies have shown that PKI-179 possesses anti-tumor capabilities[1][2].
价 格:¥电议型 号:T36084产 地:中国大陆