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T6845GNE-317inhibit,GNE-317,Inhibitor,Phosphoinositide 3-kinase,Mammalian target of Rapamycin,mTOR,GNE 31
GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).
价 格：￥电议型 号：T6845产 地：中国大陆
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T6557KU-0060648mTOR,inhibit,KU-0060648,Phosphoinositide 3-kinase,Inhibitor,Mammalian target of Rapamycin,
KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of 0.59 μM.
价 格：￥电议型 号：T6557产 地：中国大陆
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T6732WYE-687mTOR,Mammalian target of Rapamycin,WYE-687,Phosphoinositide 3-kinase,WYE687,PI3K,WYE 687,inhi
WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(T308). Selectivity for mTOR is greater than PI3Kα (>100-fold) and PI3Kγ (>500-fold).
价 格：￥电议型 号：T6732产 地：中国大陆
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TN1405Arnicolide DMammalian target of Rapamycin,Phosphoinositide 3-kinase,inhibit,Inhibitor,Caspase,mTOR,A
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D exerts strong cytotoxic activity on the human colon carcinoma HT-29 cell line.
价 格：￥电议型 号：TN1405产 地：中国大陆
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T6510GDC-0349Mammalian target of Rapamycin,GDC0349,GDC 0349,mTOR,inhibit,Autophagy,GDC-0349,Inhibitor
GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.
价 格：￥电议型 号：T6510产 地：中国大陆
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T7014VoxtalisibSAR-245409,SAR 245409,inhibit,Phosphoinositide 3-kinase,Mammalian target of Rapamycin,XL 7
Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
价 格：￥电议型 号：T7014产 地：中国大陆
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T7166GNE-493GNE493,Mammalian target of Rapamycin,PI3K,Inhibitor,inhibit,GNE-493,Phosphoinositide 3-kinase
GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR,respectively.
价 格：￥电议型 号：T7166产 地：中国大陆
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T6731WYE-354inhibit,Apoptosis,WYE354,WYE-354,WYE 354,Inhibitor,Autophagy,Mammalian target of Rapamycin,mT
WYE-354(IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT(S473) and mTORC1/P-S6K(T389), not P-AKT(T308). The selectivity for mTOR is higher than PI3Kα (>100-fold) and PI3Kγ (>500-fold).
价 格：￥电议型 号：T6731产 地：中国大陆
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T6730WAY-600inhibit,Inhibitor,mTOR,WAY 600,WAY-600,Mammalian target of Rapamycin
WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).
价 格：￥电议型 号：T6730产 地：中国大陆
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T9533BC-LI-0186Aminoacyl-tRNA Synthetase,RagD,rapamycin-resistant,BCLI0186,tRNA Synthetase, aaRS,H460,KRA
BC-LI-0186 is a potent and selective inhibitor of the interaction of Leucyl-tRNA synthetase (LRS) and Ras-related GTP-binding protein D (RagD) with IC50 of 46.11 nM. BC-LI-0186 competitively binds the RagD interaction site of LRS with Kd of 42.1 nM and has no effect on LRS-vps34, LRS-eprs, RagB-RagD association, mTORC1 complex formation. BC-LI-0186 potently inhibits the activity of tumor-associated MTOR mutants and the growth of rapamycin-resistant cancer cells. BC-LI-0186 can be used for lung c
价 格：￥电议型 号：T9533产 地：中国大陆
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T7343PF-04979064Inhibitor,Phosphoinositide 3-kinase,Mammalian target of Rapamycin,PF 04979064,PF04979064,
PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).
价 格：￥电议型 号：T7343产 地：中国大陆
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T1537Rapamycin雷帕霉素；Sirolimus；AY 22989；NSC-2260804
Rapamycin, a macrolide compound obtained from Streptomyces hygroscopicus, is a potent and specific mTOR inhibitor (IC50: 0.1 nM in HEK293 cells).
价 格：￥电议型 号：T1537产 地：中国大陆
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T1015842-(2-Tetrazolyl)rapamycin42-(2-Tetrazolyl)rapamycin
42-(2-Tetrazolyl)rapamycin is a prodrug compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1.
价 格：￥电议型 号：T10158产 地：美洲
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T1537RapamycinRapamycin,AY 22989,Sirolimus
Rapamycin, a macrolide compound obtained from Streptomyces hygroscopicus, is a potent and specific mTOR inhibitor (IC50: 0.1 nM in HEK293 cells).
价 格：￥电议型 号：T1537产 地：美洲
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T19558Seco Rapamycin sodium saltSeco Rapamycin sodium salt,Secorapamycin A monosodium,
Seco Rapamycin sodium salt is a ring-opened product of Rapamycin.
价 格：￥电议型 号：T19558产 地：美洲
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T7408428-Epirapamycin；化合物 28-Epirapamycin28-Epirapamycin
28-Epirapamycin, an impurity of Rapamycin, serves as a potent and specific mTOR inhibitor, exhibiting an IC50 value of 0.1 nM in HEK293 cells [1].
价 格：￥电议型 号：T74084产 地：中国大陆
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T74014Seco Rapamycin ethyl ester；化合物 Seco Rapamycin ethyl esterSeco Rapamycin ethyl ester
Seco Rapamycin ethyl ester, an open-ring metabolite of the Rapamycin derivative, reportedly does not impact mTOR function [1].
价 格：￥电议型 号：T74014产 地：中国大陆
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T38963Seco Rapamycin；Seco RapamycinSecorapamycin A；Secorapamycin A
Seco Rapamycin, also known as Secorapamycin A, is a ring-opened derivative derived from Rapamycin. It has been observed that Seco-rapamycin does not impact the function of mTOR.
价 格：￥电议型 号：T38963产 地：中国大陆
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T36314Wortmannin-Rapamycin Conjugate；Wortmannin-Rapamycin ConjugateWortmannin-Rapamycin Conjugate
Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin is a potent inhibitor of PI3K enzymes, while rapamycin blocks mTOR Complex 1 TORC1. Wortmannin-rapamycin conjugate consists of analogs of 17-hydroxy wortmannin and rapamycin conjugated via a prodrug linker. Hydrolysis of the prodrug linker in vivo releases the inhibitors. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in
价 格：￥电议型 号：T36314产 地：中国大陆
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T258827-O-Demethyl rapamycin；化合物 T25882CJ 12263|||CJ12263|||7-O-Demethyl Rapammune|||Novolimus (80%)|||7-O
Novolimus is a macrocyclic lactone with anti-proliferative properties. It has similar efficacy to currently available agents but requires a lower dose.
价 格：￥电议型 号：T25882产 地：中国大陆
