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T69990Ruboxistaurin mesylate monohydrate；化合物 Ruboxistaurin mesylate monohydrateRuboxistaurin mesylate mono
Ruboxistaurin mesylate monohydrate is a PKC beta inhibitor potentially for the treatment of diabetic nephropathy and diabetic macular edema. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.
价 格：￥电议型 号：T69990产 地：中国大陆
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T63013Ruboxistaurin；化合物 RuboxistaurinRuboxistaurin
Ruboxistaurin (LY333531) is a selective, orally active PKC beta inhibitor with a Ki value of 2 nM. Ruboxistaurin competitively inhibits PKC beta I (IC50: 4.7 nM) in an ATP-dependent manner. Ruboxistaurin is able to act on PKC beta II (IC50: 5.9 nM).
价 格：￥电议型 号：T63013产 地：中国大陆
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T3689LRuboxistaurin mesylate；化合物 T3689LLY-333531|||LY333531|||LY 333531|||LY-333531 Mesylate；LY-333531|||L
Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways. Ruboxistaurin inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.
价 格：￥电议型 号：T3689L产 地：中国大陆
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T3689Ruboxistaurin hydrochloride；芦布妥林Ruboxistaurin|||LY333531 HCl|||LY 333531 hydrochloride；Ruboxistaurin
Ruboxistaurin hydrochloride (LY 333531 hydrochloride) is an Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKCβ over other PKC isozymes (IC50values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 μM for PKCη, -δ, -γ, -α, -ε and -ζ respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src).
价 格：￥电议型 号：T3689产 地：中国大陆
