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T74002SJF620 hydrochloride；化合物 SJF620 hydrochlorideSJF620 hydrochloride
SJF620 hydrochloride is a PROTAC that utilizes a lenalidomide analog to recruit CRBN and ligands to target Btk, exhibiting a DC50 of 7.9 nM [1].
价 格：￥电议型 号：T74002产 地：中国大陆
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T41168SJF 0661；SJF 0661SJF 0661
SJF 0661 is the negative control for SJF 0628. Binds BRAF without inducing degradation.
价 格：￥电议型 号：T41168产 地：中国大陆
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T36246SJF 8240；SJF 8240SJF 8240
c-MET degrader. Comprises MET inhibitor foretinib (GSK 1363089) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM). Also degrades exon-14-deleted c-MET in Hs746T cells.
价 格：￥电议型 号：T36246产 地：中国大陆
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T36245SJF 1528；SJF 1528SJF 1528
Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. Comprises the EGFR inhibitor lapatinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells).
价 格：￥电议型 号：T36245产 地：中国大陆
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T36244SJF 1521；SJF 1521SJF 1521
Selective EGFR Degrader. Comprises the EGFR inhibitor lapatinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Exhibits selectivity for EGFR, including mutant forms, over HER2. Induces degradation of EGFR in OVCAR8 cells.
价 格：￥电议型 号：T36244产 地：中国大陆
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T18682SJFδ；化合物 T18682SJFδ
SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].
价 格：￥电议型 号：T18682产 地：中国大陆
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T18681SJFα；化合物 T18681SJFα
SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 μM[1].
价 格：￥电议型 号：T18681产 地：中国大陆
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T13887SJF620；化合物 T13887SJF620
SJF620 is a potent degrader of PROTAC BTK(DC50 : 7.9 nM).
价 格：￥电议型 号：T13887产 地：中国大陆
