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T9192BIIB068ADME,inhibit,FcγR,Autoimmune,Bruton tyrosine kinase,TNFα,BIIB 068,ROS,Inhibitor,reversible,Bt
BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd = 0.3 nM). BIIB068 is 400 times more selective for BTK than other kinases.
价 格:¥电议型 号:T9192产 地:中国大陆
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T6S1572Sauchinoneantioxidant,LPS,Diastereomeric,TNF-α,iNOS,anti-inflammatory,lignan,COX-2,inhibit,Nuclear f
1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative stress in vivo and in vitro. 3. Sauchinone diminishes LPS-induced neutrophil activation and acute lung injury. 4. Sauchinone-induced HO-1 expression plays a key role in the vascular protective effects of Sauchinone in HUVEC. 5. Sauchinone protects skin keratinocytes through inhi
价 格:¥电议型 号:T6S1572产 地:中国大陆
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T6S1597Mulberroside AMulberroside A,Tumor Necrosis Factor Receptor,inhibit,TNF Receptor,Tyrosinase,TNFR,Inh
1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of Mulberroside A resulted in enhanced inhibition of melanogenesis. 3. Mulberroside A has anti-inflammatory antiapoptotic effects. by decreasing the expressions of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 and inhibiting the activation of NALP3, caspase-1, and nuclear factor-κB and the phosphorylation of extra
价 格:¥电议型 号:T6S1597产 地:中国大陆
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T9921InfliximabTNFR1,Infliximab,anti-inflammatory,Avakine,Tumor Necrosis Factor Receptor,autoimmune,diabe
Infliximab is a humanized antibody against tumor necrosis factor α TNF-α) that is used in the treatment of Crohn´s disease and rheumatoid arthritis.
价 格:¥电议型 号:T9921产 地:中国大陆
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T6S0627Mesaconitineinhibit,Mesaconitine,Inhibitor,Tumor Necrosis Factor Receptor,TNFR,TNF Receptor
1. Mesaconitine has antiinflammatory activity. 2. Mesaconitine has antinociceptive activity through cyclic AMP and stimulation of the central β-adrenergic system.
价 格:¥电议型 号:T6S0627产 地:中国大陆
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T7001TIC10TIC 10,Tumor Necrosis Factor Receptor,inhibit,ONC201,Inhibitor,TNF Receptor,Apoptosis,TNFR,ONC
TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.
价 格:¥电议型 号:T7001产 地:中国大陆
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TQ0181ResatorvidTAK242,Inhibitor,MyD88,Resatorvid,inhibit,TNF-R,CLI 095,inflammatory,diseases,TNFR,CLI095,
Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 nM).
价 格:¥电议型 号:TQ0181产 地:中国大陆
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TN12917,3’,4’-Tri-O-methylluteolinCOX,TNFR,7,3’,4’TriOmethylluteolin,lipopolysaccharide,Tumor Necrosis Fac
5-Hydroxy-3´,4´,7-trimethoxyflavone has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC value of 19.0 ug/ml
价 格:¥电议型 号:TN1291产 地:中国大陆
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T6927PamapimodRo-4402257,Autophagy,Inhibitor,IL-6,TNF-α,inhibit,R-1503,IL-1β,p38 MAPK,JNK,Pamapimod,p38β,
Pamapimod (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectively with no activity against p38delta or p38 gamma isoforms.
价 格:¥电议型 号:T6927产 地:中国大陆
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T6S2140β-AnhydroicaritinβAnhydroicaritin,MMP,TNFR,β Anhydroicaritin,β-Anhydroicaritin,Interleukin Related,M
1. Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. Anhydroicaritin phytosomes can inhibit enhanced bone turnover induced by ovariectomy, improve BMD the biomechanical properties of vertebrae, without any stimulation on uterus. 3. Anhydroicaritin possesses significant protective effects on the zymosan-induced peritonitis mice, which might be associated with the regulation of Ca(2+); influx in macrophages and iNOS expression.
价 格:¥电议型 号:T6S2140产 地:中国大陆
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TN2130Manghaslinflavonoid,Manghaslin,inhibit,TNF-α,Cholinesterase (ChE),Inhibitor,glycoside,anti-inflammat
Manghaslin has considerable α-glucosidase inhibitory activity, illustrating the anti-diabetic potential of phenolic-rich litchi pulp extracts. Manghaslin also shows inhibitory activity against AChE
价 格:¥电议型 号:TN2130产 地:中国大陆
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T6S0630HypaconitineInhibitor,TNFR,TNF Receptor,inhibit,Tumor Necrosis Factor Receptor,Hypaconitine
Hypaconitine, an active and highly toxic constituent derived from Aconitum species, has anti-inflammatory activity, is widely used to treat rheumatism.
价 格:¥电议型 号:T6S0630产 地:中国大陆
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T6S2099GeraniinGeraniin,Tumor Necrosis Factor Receptor,inhibit,TNF Receptor,Inhibitor,TNFR
1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Geraniin exerts inhibitory effects on osteoclast differentiation in vitro and suppresses Ti particle-induced osteolysis in vivo, is a potential natural compound for the treatment of wear particle induced osteolysis in prostheses failure. 4. Geraniin has anti-oxidant activity, induces Nrf2-mediated expression of antioxidant enzymes HO-1 and NQO
价 格:¥电议型 号:T6S2099产 地:中国大陆
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T6649(S)-(+)-RolipramTNFα,tumor,inhibit,(S)(+)Rolipram,mononuclear,Apoptosis,phosphodiesterase,(S) (+) Ro
S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.
价 格:¥电议型 号:T6649产 地:中国大陆
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T6823E3330pancreatic cancer,TNF-α,E3330,REF-1,NF-κB,HIFs,Inhibitor,HIF-PH,Nuclear factor-kappaB,APX-3330,
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
价 格:¥电议型 号:T6823产 地:中国大陆
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T7495Hexa-D-arginineinhibit,furin,Furin Inhibitor II,TNF-α,PACE4,noncytotoxic,PC1,anthrax,PEA,HexaDargini
Hexa-D-arginine is an inhibitor of furin,blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo.
价 格:¥电议型 号:T7495产 地:中国大陆
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T7889C25-140Ubiquitin conjugating enzyme,Ubiquitin ligase,Ubiquitin activating enzyme,C25 140,TNF Recepto
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
价 格:¥电议型 号:T7889产 地:中国大陆
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T7091N-Formyl-Met-Leu-PheTNF Receptor,TNFR,Inhibitor,NFormylMetLeuPhe,Tumor Necrosis Factor Receptor,inhi
N-Formyl-Met-Leu-Phe (fMLF) is a synthetic peptide that acts as an agonist at formyl peptide receptors (FPR; Ki = 0.8 pM).
价 格:¥电议型 号:T7091产 地:中国大陆
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T8477IQ-3Inhibitor,IL-6,inhibit,TNF-α,IQ-3,JNK,IQ 3,IQ3,IL-1β,IL-1α
IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α and IL-6 production in vitro.
价 格:¥电议型 号:T8477产 地:中国大陆
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T4637R-7050R7050;R 7050;TNF-α Antagonist III
R-7050 is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.
价 格:¥电议型 号:T4637产 地:中国大陆