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T6104Cerdulatinib hydrochloridePRT 062070,PRT 2070,Inhibitor,malignancies,Tyk2,Cerdulatinib hydrochloride
Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.
价 格：￥电议型 号：T6104产 地：中国大陆
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T13232TyK2-IN-2TyK2-IN-2
TyK2-IN-2 is a selective inhibitor of TYK2(IC50s of 7 nM, 0.1 μM and 0.05 μM for TYK2 JH2, IL-23 and IFNα, respectively).
价 格：￥电议型 号：T13232产 地：美洲
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T13234Tyk2-IN-5Tyk2-IN-5
Tyk2-IN-5 is an selective and orally active inhibitor of Tyk2 JH2 (Ki of 0.086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFNα).
价 格：￥电议型 号：T13234产 地：美洲
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T75026PROTAC TYK2 degradation agent1；化合物 PROTAC TYK2 degradation agent1PROTAC TYK2 degradation agent1
PROTAC TYK2 Degradation Agent1 is a potent, subtype-selective degrader of TYK2, exhibiting degradation activity with a DC50 of 14 nM. It is utilized in autoimmune disease research [1].
价 格：￥电议型 号：T75026产 地：中国大陆
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T72421LRRK2/NUAK1/TYK2-IN-1；化合物 LRRK2/NUAK1/TYK2-IN-1LRRK2/NUAK1/TYK2-IN-1
LRRK2/NUAK1/TYK2-IN-1 (compound 226) exhibits inhibitory activity against LRRK2 (Wt), LRRK2 (G2019), TYK2, and NUAK1, demonstrating IC50 values below 10 nM. This compound is useful for research into autoimmune diseases.
价 格：￥电议型 号：T72421产 地：中国大陆
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T64265JAK1/TYK2-IN-3；化合物 JAK1/TYK2-IN-3JAK1/TYK2-IN-3
JAK1/TYK2-IN-3 is a selective, potent, orally active dual inhibitor of TYK2 (IC50: 6 nM) and JAK1 (IC50: 37 nM).JAK1/TYK2-IN-3 selectively acts on both JAK2 and JAK3 with IC50 values of 140 nM and 362 nM.JAK1/TYK2 -IN-3 regulates the expression of TYK2/JAK1-related genes and the formation of Th1, Th2 and Th17 cells to exert its anti-inflammatory activity.
价 格：￥电议型 号：T64265产 地：中国大陆
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T63146JAK2/TYK2-IN-1；化合物 JAK2/TYK2-IN-1JAK2/TYK2-IN-1
JAK2/TYK2-IN-2 is a potent and selective inhibitor of TYK2 (IC50: 9 nM) and JAK2 (IC50: 157 nM) with anti-inflammatory effects.
价 格：￥电议型 号：T63146产 地：中国大陆
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T62451TYK2-IN-12；化合物 TYK2-IN-12TYK2-IN-12
TYK2-IN-12 (compound 30) is a selective, orally active inhibitor of TYK2 (tyrosine kinase 2) (Ki: 0.51 nM). TYK2-IN-12 inhibits IL-12-induced IFNγ in human and mouse whole blood with IC50 values of 2.7 and 7.0 μM, respectively. 12 can be used to study psoriasis.
价 格：￥电议型 号：T62451产 地：中国大陆
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T61658TYK2-IN-11；化合物 TYK2-IN-11TYK2-IN-11
TYK2-IN-11 (Compound 5B) is a potent and selective inhibitor of Tyk-2, providing inhibition to TYK2-JH2 and JAK1-JH2 with IC50 values of 0.016 nM and 0.31 nM, respectively. This compound demonstrates potential for advancing research in the area of inflammatory and autoimmune diseases [1].
价 格：￥电议型 号：T61658产 地：中国大陆
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T39314JAK1/TYK2-IN-1JAK1/TYK2-IN-1JAK1/TYK2-IN-1
JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).
价 格：￥电议型 号：T39314产 地：中国大陆
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T13237LRopsacitinib；化合物RopsacitinibTyk2-IN-8|||PF-06826647；Tyk2-IN-8|||PF-06826647
Ropsacitinib (PF-06826647) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain (IC50: 17 nM).
价 格：￥电议型 号：T13237L产 地：中国大陆
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T13237Tyk2-IN-9；化合物 T13237Tyk2-IN-9
Tyk2-IN-9 (Compound 26), a selective Tyk-2 inhibitor, exhibits IC50 values of 0.076 nM for TYK2-JH2 and 1.8 nM for JAK1-JH2, respectively. This specificity makes it suitable for research into inflammatory or autoimmune diseases [1].
价 格：￥电议型 号：T13237产 地：中国大陆
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T13234Tyk2-IN-5；化合物 T13234Tyk2-IN-5
Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).
价 格：￥电议型 号：T13234产 地：中国大陆
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T13233Tyk2-IN-3；化合物 T13233Tyk2-IN-3
Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).
价 格：￥电议型 号：T13233产 地：中国大陆
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T13232TyK2-IN-2；化合物 T13232TyK2-IN-2
TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).
价 格：￥电议型 号：T13232产 地：中国大陆
