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T83739Myr-Tat-CBD3 TFA；化合物 Myr-Tat-CBD3 TFAMyr-Tat-Calcium Channel-binding Domain 3|||N-myristate-Tat-CBD3
Myr-Tat-CBD3 is a chemical compound that serves as an inhibitor of the protein-protein interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2). This compound effectively disrupts the Cav2.2-CRMP2 interaction by about 81% at a 10 ?M concentration and demonstrates an inhibitory concentration 50 (IC50) value of approximately 2.8 ?M against potassium-induced calcium influx in primary rat dorsal root ganglion (DRG) neurons. Furthermore, at
价 格：￥电议型 号：T83739产 地：中国大陆
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T83732Tat-CBD3A6K TFA；化合物 Tat-CBD3A6K TFATat-CBD3A6K TFA
Tat-CBD3A6K, a peptide derivative of the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2) interaction inhibitor Tat-CBD3, has demonstrated efficacy in a rat model of antiretroviral neuropathic pain caused by stavudine (d4T). Administered at 10 mg/kg, it preserves paw withdrawal threshold, indicating pain relief, and reduces the number of action potentials in dorsal root ganglia (DRG) neurons from affected rats. Additionally, a 30 ?M/animal dural dose
价 格：￥电议型 号：T83732产 地：中国大陆
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T83731Tat-CBD3 TFA；化合物 Tat-CBD3 TFATat-CBD3 TFA
Tat-CBD3 is a chemical compound inhibiting the interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2), as well as the interaction between CRMP2 and the NMDA receptor NR2B subunit. At a concentration of 10 ?M, Tat-CBD3 reduces the Cav2.2-CRMP2 interaction by 43% in cell-free assays and impedes the NMDA receptor NR2B subunit-CRMP2 interaction in immunoprecipitation assays. It lowers voltage-induced calcium currents by about 60% in prim
价 格：￥电议型 号：T83731产 地：中国大陆
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T80501Myr-TAT-CBD3；化合物 Myr-TAT-CBD3Myr-TAT-CBD3
Myr-TAT-CBD3, a CRMP2-CaV2.2 interaction inhibitor, has been shown to significantly attenuate carrageenan-induced thermal hypersensitivity and reverse thermal hypersensitivity in a rat model of postoperative pain, making it a useful compound for studying inflammation and postoperative pain [1].
价 格：￥电议型 号：T80501产 地：中国大陆
