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T1788TazemetostatEPZ6438;E-7438
Tazemetostat is an orally available, small molecule selective and S-adenosyl methionine (SAM) competitive inhibitor of histone methyltransferase EZH2, with potential antineoplastic activity. Upon oral administration, Tazemetostat selectively inhibits the
价 格:¥电议型 号:T1788产 地:中国大陆
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T17002Tazemetostat hydrobromide氢溴酸泰泽司他;EPZ-6438 hydrobromide;E-7438 hydrobromide
Tazemetostat hydrobromide is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 (Ki: 2.5 nM). Tazemetostat hydrobromide also inhibits EZH1 (IC50: 3
价 格:¥电议型 号:T17002产 地:中国大陆
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T1788EPZ6438EPZ6438,E-7438,Tazemetostat
Tazemetostat is an orally available, small molecule selective and S-adenosyl methionine (SAM) competitive inhibitor of histone methyltransferase EZH2, with potential antineoplastic activity. Upon oral administration, Tazemetostat selectively inhibits the
价 格:¥电议型 号:T1788产 地:美洲
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T77940Tazemetostat de(methyl morpholine)-COOH;化合物 Tazemetostat de(methyl morpholine)-COOHTazemetostat de(m
Tazemetostat de(methyl morpholine)-COOH (compound 7), a PROTAC ligand for EZH2, facilitates the synthesis of PROTACs that target this enzyme. These EZH2 degraders exhibit potent inhibition of cell viability in diffuse large B-cell lymphoma (DLBCL) and other lymphoma subtypes [1].
价 格:¥电议型 号:T77940产 地:中国大陆
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T74554Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH;化合物 Tazemetostat de(methylene morpholine)-O-C3-O
Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b), an EZH2 degrader, is employed in lymphoma research [1].
价 格:¥电议型 号:T74554产 地:中国大陆
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T70588Tazemetostat HCl;化合物 Tazemetostat HClTazemetostat HCl
Tazemetostat HCl is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation. These data demonstrate the dependency of SMARCB1
价 格:¥电议型 号:T70588产 地:中国大陆
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T1788Tazemetostat;化合物EPZ6438E-7438|||EPZ6438;E-7438|||EPZ6438
Tazemetostat (EPZ6438) is a histone methyltransferase EZH2 inhibitor (IC50=11 nM) that is orally active, selective, and SAM-competitive. Tazemetostat exhibits antitumor activity and may be used for the treatment of epithelioid sarcoma/follicular lymphoma.
价 格:¥电议型 号:T1788产 地:中国大陆
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T17002Tazemetostat hydrobromide;氢溴酸泰泽司他E-7438 hydrobromide|||EPZ-6438 hydrobromide;E-7438 hydrobromide|||氢
Tazemetostat hydrobromide (E-7438 hydrobromide) is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 (Ki: 2.5 nM). Tazemetostat hydrobromide also inhibits EZH1 (IC50: 392 nM).
价 格:¥电议型 号:T17002产 地:中国大陆
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T15240Tazemetostat trihydrochloride;化合物 T15240EPZ-6438 trihydrochloride|||E-7438 trihydrochloride;EPZ-6438
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing wild-type EZH2 (Ki: 2.5 nM). It inhibits EZH2 (IC50s: 11 and 16 nM in peptide assay and nucleosome assay).
价 格:¥电议型 号:T15240产 地:中国大陆