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T38889Thailanstatin A
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing ( IC 50 =650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC 50 s against
价 格：￥电议型 号：T38889产 地：中国大陆
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T79085MC-VC-PAB-Cyclohexanediamine-Thailanstatin A；化合物 MC-VC-PAB-Cyclohexanediamine-Thailanstatin AMC-VC-P
MC-VC-PAB-Cyclohexanediamine-Thailanstatin A is a spliceostatin analog and a drug-linker conjugate for antibody-drug conjugates (ADC), comprising the cytotoxic component Thailanstatin A and the cleavable linker (MC-vc-PAB). This compound is utilized in the synthesis of ADCs [1].
价 格：￥电议型 号：T79085产 地：中国大陆
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T39071Thailanstatin D；Thailanstatin DThailanstatin D
Thailanstatin D, an analogue of Thailanstatin A, inhibits AR-V7 gene splicing by disrupting the interaction between U2AF65 and SAP155, hindering their binding to the polypyrimidine tract situated between the branch point and the 3´ splice site. This compound displays potent tumor inhibitory properties in human castration-resistant prostate cancer (CRPC) xenografts, resulting in cellular apoptosis.
价 格：￥电议型 号：T39071产 地：中国大陆
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T38890Thailanstatin C；Thailanstatin CThailanstatin C
Thailanstatin C, an antiproliferative agent derived from Burkholderia thailandensis MSMB43, functions as a potent inhibitor of pre-mRNA splicing (IC50 = 6.84 μM).
价 格：￥电议型 号：T38890产 地：中国大陆
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T38889Thailanstatin A；泰兰斯他汀AThailanstatin A
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 =650 nM). Thailanstatin A inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC 50 s against . Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC.
价 格：￥电议型 号：T38889产 地：中国大陆
