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T6875LesinuradRDEA 594,RDEA-594,SLC22A12,Inhibitor,Lesinurad,inhibit,URAT1,Urate transporter 1
Lesinurad is a selective inhibitor of uric acid reabsorption which is used in combination with other agents in the therapy of gout. Lesinurad has had a limited clinical use but has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury.
价 格：￥电议型 号：T6875产 地：中国大陆
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T79177URAT1&XO inhibitor 2；化合物 URAT1&XO inhibitor 2URAT1&XO inhibitor 2
Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM for XO inhibition. It effectively impedes uric acid uptake in HEK293 cells with URAT1 expression, evidenced by a Ki of 0.145 μM. In hyperuricemic mice models, the compound has been shown to reduce serum urate levels and uric acid excretion, indicating potential utility for hyperuricemia research [1].
价 格：￥电议型 号：T79177产 地：中国大陆
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T79176URAT1 inhibitor 6；化合物 URAT1 inhibitor 6URAT1 inhibitor 6
URAT1 inhibitor 6 (Compound 1h), with an IC50 of 35 nM for hURAT1, demonstrates 200-fold and 8-fold greater potency compared to Lesinurad and Benzbromarone, respectively. This compound is utilized in the study of inflammation [1].
价 格：￥电议型 号：T79176产 地：中国大陆
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T79175URAT1&XO inhibitor 1；化合物 URAT1&XO inhibitor 1URAT1&XO inhibitor 1
URAT1&XO Inhibitor 1 (compound 29) serves as a dual inhibitor with IC50 values of approximately 10 μM for URAT1 and 1.01 μM for Xanthine Oxidase. It induces a hypouricemic effect in the potassium oxonate-induced hyperuricemic rat model and is utilized in research pertaining to hyperuricemia [1].
价 格：￥电议型 号：T79175产 地：中国大陆
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T79114URAT1 inhibitor 5；化合物 URAT1 inhibitor 5URAT1 inhibitor 5
URAT1 Inhibitor 5 (compound 16) serves as a powerful inhibitor of URAT1 and is utilized in hyperuricemia research [1].
价 格：￥电议型 号：T79114产 地：中国大陆
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T78195URAT1 inhibitor 8；化合物 URAT1 inhibitor 8URAT1 inhibitor 8
URAT1 Inhibitor 8 (example 247) serves as a highly potent inhibitor of URAT1, demonstrating an IC50 value of 0.001 μM. It is applicable in the study of gout [1].
价 格：￥电议型 号：T78195产 地：中国大陆
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T77517URAT1 inhibitor 7；URAT1抑制剂7URAT1 inhibitor 7
URAT1 inhibitor 7 is a novel and potent inhibitor of the human uric acid transporter protein URAT1 (IC50:12 nM).URAT1 inhibitor 7 inhibits CYP2C9 with an IC50 of 4.2 μM.URAT1 inhibitor 7 can be used to study hyperuricemia and gout.
价 格：￥电议型 号：T77517产 地：中国大陆
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T72632URAT1 inhibitor 4；化合物 URAT1 inhibitor 4URAT1 inhibitor 4
URAT1 Inhibitor 4, derived from Lesinurad, is a potent, orally active inhibitor of URAT1 with an IC50 value of 7.56 μM, demonstrating greater in vivo urate-lowering efficacy than Lesinurad [1].
价 格：￥电议型 号：T72632产 地：中国大陆
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T62825URAT1 inhibitor 2；化合物 URAT1 inhibitor 2URAT1 inhibitor 2
URAT1 inhibitor 2 is an orally active inhibitor of URAT1 and CYP isozyme with IC50 values of 1.36 μM, 16.97 μM and 5.22 μM for URAT1-mediated 14C-UA uptake, CYP1A2 and CYP2C9, respectively, URAT1 inhibitor 2 is a promising drug candidate for the study of hyperuricemia and gout.
价 格：￥电议型 号：T62825产 地：中国大陆
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T60724URAT1 inhibitor 3；化合物 URAT1 inhibitor 3URAT1 inhibitor 3
URAT1 inhibitor 3 is a potent, orally active, selective inhibitor of URAT1(IC 50 = 0.8 nM). URAT1 inhibitor 3 shows urate-lowering efficacy that can be used in gout and hyperuricemi research [1].
价 格：￥电议型 号：T60724产 地：中国大陆
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T13259URAT1 inhibitor 1；化合物 T13259URAT1 inhibitor 1
URAT1 inhibitor 1 (1g) is an inhibitor of uric acid transporter 1 (URAT1) (IC50: 32 nM), has the potential to treat hyperuricemia associated with gout.
价 格：￥电议型 号：T13259产 地：中国大陆
