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T79390Antileishmanial agent-23；化合物 Antileishmanial agent-23Antileishmanial agent-23
Antileishmanial agent-23 (compound G1/9), a potent and selective trypanothione reductase (TR) inhibitor, exhibits an IC50 of 2.24 ± 0.52 μM. It effectively inhibits the growth of Leishmania, Trypanosoma cruzi, and Trypanosoma brucei [1].
价 格：￥电议型 号：T79390产 地：中国大陆
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T74844Antiproliferative agent-23；化合物 Antiproliferative agent-23Antiproliferative agent-23
Antiproliferative agent-23, a microtubule-destabilizing agent (MDA), disrupts the tubulin-microtubule system, leading to apoptosis through a mitochondrion-dependent pathway. This involves downregulation of Bcl-2 protein, upregulation of Bax and Cyt c proteins, and activation of the caspase cascade. Additionally, it induces reactive oxygen species (ROS)-mediated endoplasmic reticulum stress in A549/CDDP cells (cisplatin-resistant cancer cell line) through the PERK/ATF4/CHOP signaling pathway, dem
价 格：￥电议型 号：T74844产 地：中国大陆
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T63525Antitubercular agent-23；化合物 Antitubercular agent-23Antitubercular agent-23
Antitubercular agent-23 is an effective anti-Candida and anti-tuberculosis agent against Candida albicans MTCC 3017 (MIC: 1.1 μg/ml) and M. tuberculosis (H37Rv) (MIC: 1 μg/ml).
价 格：￥电议型 号：T63525产 地：中国大陆
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T39889Antitumor agent-23；Antitumor agent-23Antitumor agent-23
Antitumor agent-23 exhibits potent antitumoral activity, as demonstrated by its GI50 values of 38, 48, 5, 27, 80, and 28 nM against the lymphoma cell lines GRANTA-519, KARPAS-422, KARPAS-299, RAMOS, DAUDI, and RAJI respectively.
价 格：￥电议型 号：T39889产 地：中国大陆
